JAMA+ Trials

Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources. 📬 Sign up for the JAMA+ Trials email newsletter: ja.ma/4wLWAVd

JAMA+ Trials is an online platform celebrating #ClinicalTrials, featuring curated resources, multimedia content, and a searchable collection of trial reports across the JAMA Network. 📝 Read "A Love Letter to Clinical Trials" by EIC Alison Huang, MD, MAS: ja.ma/4wGWEpj

💬 Editorial: In a randomized trial, aerobic exercise and intensive vascular risk reduction for older adults at risk of #dementia led to only modest cognitive improvement, with no significant group differences in global cognitive function. ja.ma/3Pvi2Nl

Retracted #RCTs linked to superretractors or top-cited authors were published earlier, retracted later, and accumulated more citations than other retracted trials. ja.ma/4fbogwc

💬 Viewpoint: Routine exclusion of pregnant individuals from RCTs has resulted in gaps in drug safety data, which can lead to unrecognized risks, inappropriate medication avoidance, or delayed guideline recommendations. ja.ma/3RtMWGs

Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources. 📬 Sign up for the JAMA+ Trials email newsletter: ja.ma/4uDiGr9

JAMA+ Trials is an online platform celebrating #ClinicalTrials, featuring curated resources, multimedia content, and a searchable collection of trial reports across the JAMA Network. 📝 Read "A Love Letter to Clinical Trials" by EIC Alison Huang, MD, MAS: ja.ma/3PqRdtL

Political ideology was associated with clinical trial skepticism, with conservative respondents expressing greater mistrust; tailored recruitment strategies may improve enrollment diversity. ja.ma/3Pviuv2

Remote, scalable cognitive behavioral therapy–based chronic pain programs are effective for treating individuals with high-impact chronic pain. jamanetwork.com/journals/jama/…

Remote #UI behavioral management for women veterans via mobile app or video visit improved symptoms, with no clinically meaningful difference between modalities at 12 or 24 weeks. ja.ma/42K6g4C

Daily full-body emollient use from infancy to age 2 reduced #AtopicDermatitis incidence in community-based infants; benefits were greatest for low-risk infants and those with a dog in the household. jamanetwork.com/journals/jamad…

💬 Editorial: Virtual and remote #ClinicalTrials can expand access and capture real‑world outcomes, but they require careful design to address data quality, patient safety monitoring, and participant engagement without in‑person contact. ja.ma/48GLPsR

Patch-based remote ECG screening for atrial fibrillation in older individuals with moderate to high risk of stroke modestly increased diagnosis and anticoagulation but had limited effect on #stroke rates. ja.ma/3P03bdu

JAMA+ Trials highlights the implications and innovations of clinical trial research from across the JAMA Network to advance evidence-based medicine and public health. Follow @JAMAplusTrials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources. 📬 Sign up for the JAMA+ Trials email newsletter: ja.ma/4eHP473

JAMA and JAMA Network Editor in Chief Kirsten Bibbins‑Domingo, PhD, MD, MAS, selected this study as one of her favorite trials of 2025, citing its physiologically grounded design, use of scalable bedside assessments, and extensive international investigator collaboration. The trial illustrates how personalized resuscitation strategies can be rigorously evaluated across diverse clinical settings. 📖 Read the full trial: ja.ma/4mOTawb

In patients with early septic shock, the ANDROMEDA‑SHOCK‑2 randomized clinical trial evaluated a personalized hemodynamic resuscitation protocol targeting normalization of capillary refill time. Compared with usual care, this strategy was superior for a hierarchical composite outcome of mortality, duration of vital support, and length of hospital stay at 28 days, with the overall benefit primarily attributable to a shorter duration of organ support. 🧵

Led by Editor in Chief Alison Huang, MD, MAS, JAMA+ Trials brings together recent clinical trial reports from the 13 JAMA Network journals, multimedia explorations of emerging trends, and educational resources on trial design, conduct, and reporting. 📝 Read the launch editorial: ja.ma/4dOqi51 📬 Sign up for the JAMA+ Trials email newsletter: ja.ma/4mx0WdZ 👉 Follow JAMA+ Trials on X: @JAMAplusTrials

Today, the JAMA Network launches @JAMAplusTrials, a new online platform that highlights the vision, innovation, and resilience of clinical trial research. Designed for clinicians, investigators, trainees, and others engaged in clinical research worldwide, JAMA+ Trials is an interdisciplinary resource for enhancing insights and promoting dialogue in clinical trial research. 🧵