Wouter Franssen

Online Now: Adipose tissue-derived extracellular vesicles as drivers of endothelial dysfunction in obesity dlvr.it/TRk2kP #trends #endocrinology #metabolism

Some people exercise religiously and barely improve. Scientists may have found why. IGFBP7, a protein secreted by senescent cells, acts as a molecular brake on exercise adaptation. Older adults completing 1 year of HIIT: those with higher baseline IGFBP7 gained significantly less fitness. In mice, deleting IGFBP7 amplified training gains. Overexpressing it abolished them entirely. UK Biobank data (n=45,438): lower IGFBP7 correlated with reduced mortality across multiple age-related diseases. The ceiling on your fitness gains might not be your willpower or your training plan. It could be a senescence protein that constrains how much your body can adapt. The next question: can we lower it?

Online Now: Regulation of skeletal muscle mitochondrial fuel utilization during exercise dlvr.it/TRgvcG #trends #endocrinology #metabolism

A single session of sprint interval exercise elicits more pronounced effects on measures of skeletal muscle insulin sensitivity than a single bout of moderate-intensity continuous exercise bit.ly/4bFneoR

New! Online now: Exercise as a therapeutic intervention for long-lasting and chronic diseases dlvr.it/TRfmH7

Online Now: Exercise timing and circadian regulation of metabolism in type 2 diabetes dlvr.it/TRbFBs #trends #endocrinology #metabolism

High-intensity interval training increases mitochondrial cristae density (~7%) in human skeletal muscle, demonstrating preserved mitochondrial ultrastructural adaptability even in individuals with type 2 diabetes #T2D #DiabetesResearch link.springer.com/article/10.100… 🔓

Micro-exercise breaks every hour: a feasible strategy to improve metabolic health in sedentary office workers 3 minutes of body weight exercise every hour from 9 AM to 5 PM

Aim for 7000 steps a day 🐾

New content online: Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases dlvr.it/TRNydw

Living in 🌳 and 🏞️ environment is associated with lower incidence of heart failure 💔 Learn more about the best living space for your 💓 👉 doi.org/10.1093/eurjpc…

Online Now: The reciprocal endothelium-adipose loop fuels cardiometabolic diseases dlvr.it/TRFHsJ #trends #endocrinology #metabolism

💪 High intensity interval aerobic excercise (HIIE) has shown superior efficacy over moderate continuous exercise in enhancing endothelial function. A progressive training strategy is recommended to maximise long-term results. Check this meta-analysis👉doi.org/10.1093/eurjpc…

Moderate wine consumption, as part of the Mediterranean Diet, is associated with lower mortality and cardiovascular disease risk. Read more in #EHJ 👉 academic.oup.com/eurheartj/adva… @ESC_Journals @escardio #CardioTwitter

Are you a 'morning mover', accumulating your steps on your commute? Or do you leave it until the afternoon or evening? Interesting findings from The Maastricht Study reveal timing might make a difference for T2 Diabetes Mellitus: …ubs.pericles-prod.literatumonline.com/doi/10.1111/do…

Here, 3-minute hourly micro-exercise breaks during workdays led to improved markers of cardiometabolic health in sedentary office workers.

NEW PAPER: 5 - 2: Hanggi et al. Movement patterns of youth and their parents: cross-sectional and longitudinal associations Read open access @: link.springer.com/journal/44167/…

Principles of Exercise Prescription (& muscle contraction) for Brain Health in Ageing Exercise 👉🏼muscle contraction 👉🏼l-lactate👉🏼bloodstream 👉🏼blood-brain barrier 👉🏼BDNF activation in the hippocampus👉🏼improved neuroplasticity👉🏼improved cognitive function journals.lww.com/acsm-esm/fullt…

Fascinating study on the relationship between all cause mortality and different types of physical exercise. I'll keep walking! bmjmedicine.bmj.com/content/5/1/e0…

NEW PAPER: 5 -1: Fairclough et al. Trajectories of children’s physical activity volume and intensity across the school year: the Ready, Set, Move project read open access @: link.springer.com/journal/44167/…