Broad Institute

Our manuscript led by @NakaoTetsushi @skoyamamd - a comprehensive characterization of leukocyte telomere length (LTL), a hallmark of biological aging across the US nature.com/articles/s4158… @NatureGenet Quick summary of lessons learned:

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s4158… And a special shoutout to the lead author @snaga13 A 🧵

The first ever large scale study of whole genomes from Anopheles darlingi -- a key malaria vector in the Americas -- reveals signs of emerging insecticide resistance. broad.io/Anopheles-darl…

New research published today in @naturemagazine could reshape our understanding of how #ColorectalCancer develops in people under the age of 50. Team #PROSPECT, tackling the early-onset cancers challenge, has revealed how the epigenome “remembers” inflammation, priming cells for cancer risk in mice. We spoke with @snaga13 and @JD_Buenrostro about what these findings mean for patients & next steps in combatting and preventing this disease. Learn more via the link below👇 🔗 cancergrandchallenges.org/news/the-epige…

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. broad.io/colitis-news

By analyzing DNA data from over 900,000 people, a new study found that some of the most common viruses hiding in the body vary with age, sex, and the seasons — and that genes influence the long-term effects these viruses have on our health. broad.io/virome-news

Your patient develops transient #afib in the setting of physiologic stress ("stressor-associated AF"). Do they "really" have AF? Will it come back? How to treat? NEW analysis @JAHA_AHA led by 🌟 fellow @MGHHeartHealth @JHaimovichMD shows ECG-based #AI is here to help! Thread ⬇️

Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease. doi.org/10.1002/alz.71… @broadinstitute @MGHMolBio @MGBResearchNews #Alzheimers

✨ Registration for CLeaR 2026 is now open! broadinstitute.swoogo.com/2026clear ⭐ CLeaR 2026 📅 Monday, April 6 – Wednesday, April 8 📍 Broad Institute and virtually 📃 Stay tuned for the full agenda Learn more: cclear.cc/2026 @Conf_CLeaR @broadinstitute

🚨🧬🩸 Delighted to have this @NatureRevGenet review w/ @michaelpoeschla published today - Genetic Influences on #hematopoiesis: rdcu.be/e9vlD

🧵 Introducing SpatialFusion: a lightweight #multimodal #FoundationModel for pathway-informed spatial #niche mapping. 📄 doi.org/10.64898/2026.… It combines #histopathology and #SpatialTranscriptomics to identify functional microenvironments in tissue. Here’s what we found 👇

Delighted to share our proteomics study by @Jiwoo__Lee @mit_hst @harvardmed & @BellomoTiffany @MGHVascular prioritizing TNFR pathway proteins & recurrent CAD events sciencedirect.com/science/articl… @JACCJournals #JACCAdv

🎉 We are excited to share new work led by @Schmidt_Center postdoctoral fellow @JoYatesResearch: SpatialFusion, a multimodal foundation model that identifies tissue niches based on pathway activity—not just spatial proximity. Learn more ⬇️ @broadinstitute

After a harrowing mental health crisis, a family’s giving to the Broad Institute’s research tops $1 billion trib.al/A5KSnaB

We are incredibly grateful to The Stanley Family Foundation for their transformative support of bipolar disorder and schizophrenia research. bostonglobe.com/2026/03/18/bus…

🎉 Congrats to @Schmidt_Center’s @ChujunHe123, @AmodioMatt, Orr Ashenberg, Caroline Uhler and colleagues on their Nature Communications paper! They introduce TRIM, integrating single-cell RNA + TCR data to study immune responses to cancer immunotherapy. #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Join us tonight online or in person: broadinstitute.swoogo.com/discovery26

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. nature.com/articles/s4146… @broadinstitute @MGHMolBio @MGBResearchNews

The Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News