Jim
83 posts
@BioBoyScout We have 5 data readouts between August and end of year. The $SRPT muscle readout might take another month or so. Hopefully will generate buyout talk.
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The Acquisition of the Decade.
In chess, the queen is the most powerful piece on the board. $ARWR is the queen of biotech M&A this decade.
The four arguments inside my latest note.
bioboyscout.com/p/the-acquisit…
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How would you rate Trump’s first year of his second term? 👇👇
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@BioBoyScout Question: Should tau protein reduction be expected to be the same in healthy volunteers as in Alzheimer’s patients with ARO MAPT
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New note: ARO-MAPT: Proof of Mechanism
$BIIB CELIA validated the tau hypothesis. Mechanism works. Bear case answered. $ARWR's ARO-MAPT now sits with structural delivery advantages and proof of mechanism in hand.
bioboyscout.com/p/aro-mapt-pro…
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@RNAiAnalyst Will be interesting to see $ARWR results with Subq delivery. Same target.
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$biib $ions Important study of (intra- and extracellular) lowering uf #tau in Alzheimer's using oligo modality.
Apparently some slowing of cognitive decline observed in this 18 month pbo-controlled study, but missed primary, also due to lack of dose response.
Ionis@ionispharma
Today, with @Biogen, we shared topline results from the Phase 2 study of our investigational ASO for the potential treatment of early #AlzheimersDisease. Read more: ir.ionis.com/news-releases/… $IONS
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@RNAiAnalyst Considering $ARWR is only one with Subq delivery at present I would say them. Reported more positive preclinical data at Tides yesterday. Reaching deep brain regions IT is not.
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$biib $ions now who will be the first with a systemically delivered amyloid beta-tau oligo combo in the clinic? $arwr $alny
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@tinaxkitsune Girlfriend would be nice. Wife would be even better!
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I told Clarence today that if he doesn't ask Guyton if they lost his luggage or something he's not doing his best job of beat writing.
Dallas Cowboys@dallascowboys
Congrats to the Beebe's 🥳
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George Pickens Drama Over? + How He Avoided a Micah Situation | Doin' Al... youtu.be/2ny707oaERI?si… via @YouTube
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What stands out first to you in this new photo?
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@CrwnGlobalMedia @YouTube Where did you have Lawrence on your board? Saw where Voch had him at 24
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COWBOYS DRAFT CALEB DOWNS & MALACHI LAWRENCE!!! | Crown Global Media Ins... youtube.com/live/ADZ6SUSSr… via @YouTube
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Who is one player you’re praying the Cowboys come away with this weekend?
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