Mylène Botbol-Baum

Introduction : Bioéthique et qualité de vie du sujet capable : bien être et choix social europepmc.org/article/med/28…

@prof_goldberg Disgusted

@NitaFarahany And an adapted code of research ethics.....

In case anyone needs a refresher: human decisions will matter more, not less, in the age of AI. Humans decide the values that guide AI systems & determine what data is used to train them. Responsible AI requires ethical innovation from the very start. bit.ly/46TmyJv

@UrnovFyodor No guarantee ever but the minimal risk cannot be assured here...

@M_Botbol_Baum There is no “try” here - the purpose of any phase 1/2 in this space is TO establish safety. There is no try.

This investment by the US Federal Government in charting and funding new paths of genome editing to the clinic is EXACTLY the right step towards expanding the public health footprint of #CRISPR in genetic disease. The NIH is supporting academia-led paths of editing to IND!

@HankGreelyLSJU Nobody is indispensable but everyone is unique...

I am sorry it came to this & feel bad for Tessier-Lavigne. He was (largely) exonerated but I think he's right that his resignation now is best for Stanford. & continuing could not have been any fun for HIM. He's a man of integrity, but, like all, not perfect. I wish him the best.

@UrnovFyodor I would say... try ...to establish safety since uncertainty is on both sides ...and the social reception of disruptive representations unpredictable...

@M_Botbol_Baum The only way to establish long term safety and efficacy of any genetic medicine is to treat individuals with severe disease in clinical trials. No one "promises safety" - the objective of any phase 1/2 in this field is to ESTABLISH safety.

@UrnovFyodor Thanks for the precision but it is important to mention those with severe diseases as condition to experiment with those innovative drugs.

@EtienneKlein Une disruption de l esprit....

Paul Valéry est mort il y a 78 ans jour pour jour. En 1939, il écrivait, à propos du « destin de l’Esprit » : « L’exagération de tous les moyens de communication soumet les esprits à une agitation et une nervosité généralisée ». Quels mots utiliserait-il pour aujourd’hui ?

@C_G_S 2026? It might be a total other game by then!

The European parliament approved rules aimed at setting a global standard for artificial intelligence, including automated medical diagnoses, but the regulations would not come into effect until 2026. theguardian.com/technology/202…

@julianhitchcock @hannahdev @ISSCR Thanks.

@M_Botbol_Baum @hannahdev @ISSCR FYI inquisitiveminds.bristows.com/post/102ii9v/s…

NEW: Scientists have created a model human embryo with a heartbeat and blood. My latest piece on synthetic embryos: theguardian.com/science/2023/j…

@donalddhoffman Interesting although simplistic at least it is not dualist.

"This suggests that consciousness—of some primitive and rudimentary form—is the hardware that the software described by physics runs on. The physical world can be conceived of as a structure of conscious experiences." nautil.us/is-matter-cons…

@HankGreelyLSJU @carlzimmer An embryo can be transplanted in a uterus and develop stembryos are not embryos yet....

An unsurprisingly good column by @carlzimmer on the recent embryo models preprints. I have 3 qualms, tho. 1st, he says the scientists say these aren't "true" embryos & could never give rise to babies. I believe that's what they say BUT a) legally, what IS an embryo depends on

Our July ELSIcon Special Issue is out! Read it here: tandfonline.com/toc/uajb20/23/… #MedEd #ELSI #genetics

@antonioregalado And it is also so expensive whose child could... benefit ...if there is any benefice at all ! it is a form of human experimentation transferring the risk on the patient.

FDA approves a gene therapy for Duchenne Muscular Dystrophy, limited to younger kids. Data for benefit seemed to be equivocal. Maybe some 'better than nothing' reasoning here. yahoo.com/news/us-fda-ap…

@antonioregalado It is irresponsible in my mind ..it could also be worse than nothing. .....

@g_levrier @antonioregalado @HankGreelyLSJU An organism like but not an organism proper according to definition ..the dimension of time would be involved here...

@antonioregalado Something for @HankGreelyLSJU to answer!

Nature provides a corrective to last week's confused headline in a British tabloid about synthetic human embryos, aka embryo models made from stem cells (a) Synthetic human embryos are not new (b) latest batch lay claim to enhanced verisimilitude. nature.com/articles/d4158…

@julianhitchcock @hannahdev @ISSCR I agree it would be better to speak of embryo like?

@hannahdev It’s a great piece, Hannah. Lots of activity with papers to follow. My only quibble is with the moniker. As #SCBEMs are NOT embryos, would it be possible to stop referring to them as “synthetic embryos”? @ISSCR

Mylene Botbol @M_Botbol_Baum @UCLouvain_be @CENTERHELESI discusses Walter Benjamin's messianism and how it impacts on the text of 1921, Critique of violence buff.ly/3Nz6zbP #philosophy #walterbenjamin

@RaphaelZaguryOr Bon souvenir....

La Nuit de la Philo et de la Démocratie à Tel Aviv – 7ème édition Commissariat : Raphael Zagury-Orly Le jeudi 1er juin à partir de 18:45 La Nuit de la philosophie aura lieu cette année dans plusieurs lieux à Tel-Aviv ➡️Voir le programme de la nuit : bit.ly/Night-of-philo…

@CathyHerbrand @NewYorker I read it interesting narrative but it does not take Crispr potential fir disruption seriously enough

The Future of Fertility newyorker.com/magazine/2023/… via @NewYorker