Mitohacker

Most health advice skips the part where you understand why it works. Mitochondria. Energy. Hormones. Sleep. Longevity. Mechanisms, protocols, sources. Follow if you want to read the studies without reading the studies.

Obraztsov and Strazhesko described MI clinically in 1910, and Hammer diagnosed coronary thrombosis antemortem in 1878, so the disease predates Crisco. The stronger case is the mechanism: partially hydrogenated cottonseed oil is a direct source of trans fats, which raise Lp(a) and shift LDL toward the small dense pattern that actually drives plaque formation.

The first heart attack ever described in a medical journal was recorded in 1912 by James Herrick. Before 1912, the disease was so rare that doctors did not have a name for it. Crisco was launched in 1911. The American Heart Association was founded in 1924, partly to figure out where this new disease had come from. In 1948, the AHA received a $1.7 million donation from Procter and Gamble. Procter and Gamble made Crisco. The AHA has not commented.

Red light at 670nm knocks nitric oxide off Complex IV in your mitochondria. That's the enzyme responsible for the final step of energy production, and nitric oxide sitting on it acts like a brake. Remove the brake, electron flow speeds up, ATP output increases. Muscle cells with more ATP available pull glucose out of the blood faster, which is the insulin sensitivity effect.

Red light rapidly improves insulin sensitivity in trial. Just 15 minutes lowered blood sugar by >25%, by: ◇ Increasing mitochondrial metabolism ◇ Increasing CO2 output ◇ Reducing free radical generation ◇ Lowering inflammation 670 nm - one of the best ways to boost your metabolism.

@hubermanlab Penile duplex ultrasound. Half the anecdotal reports are about girth gains, which tracks perfectly with BPC-157’s angiogenesis mechanisms. If new blood vessel formation is real, erectile tissue would show it before any tendon imaging could.

I can’t see any reason why a proper multi site RCT of BPC157 done by a few independent groups wouldn’t help clarify any real vs placebo effects. The challenge: no one wants to pony up the $ (more like $$$$ to do it right) but if it were done, what endpoints would you want to see?

L-theanine boosts GABA and serotonin, which are the same pathways alcohol hits to take the edge off. At gram doses you're basically giving your brain the signal it was chasing from the drink without the dopamine crash that drives the habit loop. There's a 2024 RCT showing 400mg reduced alcohol consumption in heavy drinkers by 30%.

went through a period of stress so severe that out of lack of better ways to cope, I started overdosing on l-theanine (~gram per coffee) and it completely DELETED my year and a half-long alcohol habit that had been sort of weighing on me at times I was convinced I’d turn into a full-blown alcoholic from the stress but l-theanine had other plans. incredible. couldn’t recommend it enough W-Theanine

Ruminants are biological upgraders. They take plant material humans handle poorly and convert it into highly bioavailable protein, heme iron, B12, zinc, creatine, carnosine, and fat-soluble nutrients. You’re not just “eating plants instead.” You’re eating what a rumen and its microbes already processed for you.

The cow ate the grass. The grass had lectins, oxalates, phytates, tannins, protease inhibitors, and a collection of secondary metabolites the plant evolved specifically to deter things from eating it. The cow did not care. The cow has four stomachs, a rumen full of microorganisms that have been doing this job for millions of years, and absolutely zero interest in the plant's feelings about being eaten. What came out the other side: complete protein with every essential amino acid, B12, zinc, iron in the most bioavailable form that exists, fat-soluble vitamins A, D, E and K2, creatine, carnosine, taurine, conjugated linoleic acid, and omega-3s. What did not come out: the lectins. The oxalates. The phytates. The antinutrients. The toxins. The plant's entire chemical defence system. The cow is a biological refinery that takes difficult raw materials, runs them through a process that took millions of years to perfect, and produces the cleanest, densest, most bioavailable nutrition that has ever existed on this planet. You are not eating instead of plants when you eat beef. You are eating the best version of plants that has ever been made available to you. The cow did the hard part. You just have to eat it.

@NTFabiano Depressed brains produce measurably less ATP. Same mitochondrial defect, Complex I, shows up across depression, bipolar, and schizophrenia in 67 studies. Exercise hits double the effect size of SSRIs because it builds new mitochondria, not just more serotonin.

Metabolic health is mental health. Exercise & diet must be first-line treatments.

@NicHulscher The mechanism is NIR light displacing nitric oxide from Complex IV, which directly speeds up ATP production. That's why red light panels at 810-870nm replicate the effect, it's not the vitamin D doing the mitochondrial work

A recent study demonstrated that sunlight penetrates THROUGH the human body and RAPIDLY improves mitochondrial function. That explains why two studies found sunlight and vitamin D RESOLVED long-vaccine syndrome in 82% of patients and improved vaccine heart damage. Get sun.

Helgeplaner utgår, uten unntak

@SharonC97936831 Ill recommend also trying; Methylene Blue High dose creatine And Epicapstein.

I’ve moved the needle from severe (quite ill) to moderate and keep improving. I have a cocktail of medications and therapeutics that enabled this: LDN 4.5 mg; D-Ribose; Hydrogen water (8 oz; 3 times daily) And Doxepin for sleep (insomnia). Low dose Doxepin. Everyone makes their own decisions re trying things that could help alleviate symptoms ; give them a lift. It’s a personal decision along with their doctors. Nothing wrong w trying IMO

@kevinnguyendn @Mmartain I have put a cheaper model on it, but it still eats token from opus when it gets feed the information? Anyway to prevent this?

Token bloat is the exact hurdle we're tackling next. Right now it scales like a normal file system, which eats up extra context as it grows. To handle that exact bloat, we're shipping conflict resolution, auto-merging, renaming, and dynamic context moving real soon to keep the tree clean and token costs dow

Memory for OpenClaw is now Native! Our first OpenClaw Memory Skill was a massive success: 30k+ downloads in a week and 500k+ organic impressions overnight for launch post. But we knew memory needed to be native. On March 21, OpenClaw merged PR #50848, allowing us to go beyond the skill layer and integrate directly into the agent’s context assembly flow. We try to make OpenClaw a truly 24/7 employee capable of complex workflows. The technical setup isn’t the hardest part but the real challenge is giving it a "brain" that remembers exact project details, past decisions, and team changes over time. The Native Memory Plugin is now live on NPM & ClawHub. Here is what it brings to your OpenClaw agents: 👉 Native Integration: Automatically manages a Three-Layer Memory architecture (Context Tree, Workspace Memory, Daily Memory). 👉 Git-like Stateful Memory: Organizes memory into a semantic hierarchy of human-readable, diffable Markdown files. You always get updated knowledge and can actually see and fix what your agent learns. 👉 Top Market Accuracy: Achieves an industry-leading 92.2% retrieval accuracy (LoCoMo & LongMemEval benchmarks), maintaining 90% accuracy even with cheap, lightweight models. 👉 Local-first & Portable: Local-by-default, fully portable for multi-agent teams. 👉 Super Easy Setup

The L. reuteri research in mice does show an oxytocin-related effect, but it is likely mediated neurally through the vagus rather than by directly raising oxytocin from the gut into the bloodstream. That matters, because most supplements marketed around this idea are not actually reproducing the strains or dosing used in the studies.

There's a single gut microbe that influences your mood, your sleep, your skin, and even your muscle mass. 96% of people have lost it. Scientists just discovered it triggers your body to produce the "Love Hormone" oxytocin. Not in your brain, but in your gut. The microbe is called Lactobacillus reuteri (L. reuteri). It used to live in nearly every human gut on Earth. Today - Antibiotics, processed food, and modern living have wiped it out of almost everyone. If you've taken even one round of antibiotics in your life, Yours is probably gone. Researchers at Baylor College of Medicine made a stunning discovery. They found that oxytocin - The hormone linked to mood, bonding, stress relief, and healing - is produced in your small intestine. Not just your brain. Your gut. And L. reuteri is what can trigger its release. How does it work? L. reuteri stimulates special cells in your intestinal lining to release a hormone called secretin. Secretin then signals nearby cells called enterocytes to produce and secrete oxytocin. Your gut is literally manufacturing one of the most powerful hormones in your body. And - It's published science. The Baylor team confirmed it using human intestinal tissue, gene expression data, and lab-grown intestinal cultures. The highest concentration of oxytocin-producing cells? The small intestine. Dr. William Davis - the physician who wrote "Wheat Belly" and "Super Gut" ... figured out how to grow L. reuteri at home using a simple fermentation process. Not a pill Not a supplement A highly concentrated probiotic food you make yourself. Here's what people are reporting after restoring L. reuteri: - Deep, uninterrupted sleep - Reduced anxiety and improved mood - Thicker hair and younger-looking skin - Increased muscle mass (even without heavy exercise) - A 50% rise in testosterone in men over 50 - Faster wound healing - Restored libido MIT researchers tested it in mice. The ones given L. reuteri stayed lean, kept their fur, mated, and aged gracefully. The control group (same diet, no L. reuteri) - Got fat, lost their hair, stopped mating, and died early. Same crappy diet. Completely different outcome. Why? Because L. reuteri does something most probiotics can't. It colonizes your entire small intestine - ALL 24 feet of it. It produces natural antibiotics called bacteriocins that kill harmful bacteria. And it prevents the toxic migration of fecal microbes into your upper gut. When those bad microbes invade the small intestine, they release toxins into your bloodstream. That's called endotoxemia. It drives weight gain, brain fog, type 2 diabetes, cognitive decline - And is now being linked to multiple forms of the Big C. L. reuteri helps stop that at the source. The key? Dr. Davis found that fermenting L. reuteri at 99°F for 36 hours produces roughly 300 billion microbes per serving. More than 30X a typical supplement. A half cup a day is the protocol. I've been saying for 30 years: your mood, your anxiety, your energy - It starts in the gut. When I healed my gut, my crippling anxiety disappeared. Not from medication. From fixing the actual cause. Now science is catching up. And L. reuteri is one of the biggest reasons why. Comment GUIDE and I'll send you a FREE guide on how to make unlimited probiotics at home.

Gear raises the ceiling on protein synthesis and recovery, but the training stimulus still has to be there. If you’re not creating enough tension and disruption in the muscle, the enhanced hormonal environment has nothing to build on. It’s mostly an amplifier, not a substitute for training.

Clavicular has shown us that you can be on testosterone, GH, 20 years old and still have a very mid physique

The tripling tracks with ultrasound adoption, not with actual thyroid cancer deaths, which have stayed flat. Take South Korea they screened aggressively, saw a 15x spike in diagnoses, pulled back on screening, and the rate dropped. Most of what's being caught are small papillary tumors that would never have caused symptoms.

Thyroid cancer used to hit people in their 60s. Now it's the #1 most common cancer in young adults aged 16-33. According to the National Cancer Institute, diagnoses have tripled since the 1990s. Here are 8 things destroying your thyroid without you realizing: 1. Tap water

That is wrong. Most serotonin-syndrome cases involving methylene blue come from IV use at surgical doses, not low dose oral use. At oral doses, MAO-A inhibition is much milder. And this stack uses tyrosine, not tryptophan, so the overlap is primarily dopaminergic rather than serotonergic.

@Mitohacked @metabolic_print No. Serotinergic

Surviving a day after bad sleep: - 500mg aspirin - 100mg CoQ10 - 15g creatine - 1g tyrosine - Tons of sugar in my coffee

The real reward was the anticipation, not the activity itself. Dopamine tracks novelty, salience, and expected payoff more than stable repetition. Once that signal normalizes, motivation often collapses back to baseline. In ADHD, that drop can feel even steeper, which is why the pattern so often ends with abandoned supplies and a new obsession already forming.

The ADHD hyperfocus crash is brutal. You wake up on a random Tuesday, and the obsession that literally gave you the will to live for the last three weeks suddenly provides zero dopamine. Now you just have a $300 pile of supplies and a profound sense of emptiness.

If you had to rank the list, sleep is near the top. Testosterone release is closely coupled to normal sleep physiology, and restricting sleep to around five hours per night has been linked to significant drops in testosterone within a week. That makes sleep one of the fastest ways to move the system in the wrong direction.

A doctor who treated men with erectile problems for 23 years revealed what slowly destroys men's sexual health. He said, “Most men damage their sexual health without realizing it.” Every man must read this...

The negativity bias is well established. The brain is built to prioritize potential threats over potential gains, which made sense for survival but often works against us in modern environments. Visualization does have some support, mostly from mental-rehearsal research, but it works through attentional shaping rather than any literal rewiring of reality.

your mind tends to dwell on worst case scenario... so you need to actively do the opposite sit in silence for 5 minutes each morning and FEEL as if the best possible thing could happen to you. this is how you reprogram your mind

The important part is that MOTS-c may bypass the usual requirement for exercise induced signaling. Most compounds that support energy metabolism in healthy people work best when paired with actual mitochondrial stress from activity. MOTS-c is potentially different because it activates AMPK directly, which could make it more relevant for people with impaired post-exertional recovery.

If you have chronic fatigue syndrome, mots-c MIGHT be preferable to most supplements promising to cure your fatigue. Supplements that believe it or not, don’t have that much research behind them when it comes to CFS. Heck, they don’t even show a lot of results for long covid. *People with CFS can’t really work out with makes mots-c even more beneficial potentially.

@NTFabiano At the neural level, this is Hebbian conditioning. Repetition increases synaptic strength and makes the circuit more likely to activate again in the future. The problem is that the brain does not selectively reinforce only beneficial behaviors.

Repetition rewires your brain. Repeat what you want to become. This is neuroplasticity.