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Collin Nadarajah
24 posts
Collin Nadarajah
@Neuro_Nada
MD/PhD Candidate | Washington University School of Medicine @ErikMusiek Lab Alum. Glia and neurodegeneration
St. Louis Katılım Aralık 2022
181 Takip Edilen120 Takipçiler
Collin Nadarajah retweetledi
REV-ERBa/b DKO causes massive changes in brain gene expression and induces cell-autonomous astrocyte reactivity, enhancing aSyn degradation and lysosomal fxn in vitro, and mitigating aSyn spreading in vivo. These finding further support REV-ERB inhibition as a therapeutic target.
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Excited that my thesis work from @ErikMusiek lab is out now! We describe the role of REV-ERB alpha and beta in regulating key neurological phenotypes, including modulating astrocyte reactivity and function in a cell-autonomous manner. Out in @PNASNews now
Erik Musiek@ErikMusiek
Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS pnas.org/doi/10.1073/pn…
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Collin Nadarajah retweetledi
Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes.
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS pnas.org/doi/10.1073/pn…
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Turning 30 today and this decade is going to bring some fun and interesting things real soon:
-Defending my PhD Thesis in a couple months
-Going back to med school in June
-Go to residency and learn how to be physician
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4 years ago on #ElectionDay , I was studying for Cardio, Pulm, Renal, and Path block exams that week (that was a fun time 😅)
Now during #Election2024 I’m putting together my first solo first author manuscript.
Times change and yet the stress and deadlines remain
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the weirdest places I’ve seen the Eduroam WIFI so far: a small monastery on a lake an hour outside Munich and the Dachau concentration camp memorial
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Collin Nadarajah retweetledi
MSTP student extraordinaire @Neuro_Nada delivering his talk on astrocyte REV-ERBs at #CSHLglia. It's a big stage but he did very well. My first time at the meeting and it was great. Thanks to @ErinMGibson for highlighting our glial circadian translatome paper.
Queens, NY 🇺🇸 English
Very rewarding to see all of Michelle’s hard work and persistence pay off. Fantastic student and budding scientist.
Erik Musiek@ErikMusiek
Congrats to super-student Michelle Li and her bench mentor @Neuro_Nada on winning best undergraduate poster at the @WUADRC pre-AAIC poster session!
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The only time I’ll be able to post this. Started the MSTP as a bright eyed 24 year old. Now hopefully in the second half 😅😅
GIF
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I’ve only written the wrong year on my samples twice so far. It’s the small joys.
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Lab has been rough of late but that doesn’t matter…
THE TEXAS RANGERS ARE AMERICAN LEAGUE CHAMPIONS!!!
#GoAndTakeIt
World Series here we come!!
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Collin Nadarajah retweetledi
Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇
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Collin Nadarajah retweetledi
Excited to share @patwsheehan and @Neuro_Nada's new paper with @GusDavisLab out in @NeuroCellPress! Circadian clock disruption via Bmal1 KO protects against tau and synuclein pathology. How can this be? It’s the astrocytes! This led us to astrocyte BAG3 as a protective response.
Pat Sheehan@patwsheehan
Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇
St Louis, MO 🇺🇸 English
Our @NeuroCellPress paper is finally out! We found a Bmal1-Bag3 axis in Astrocytes that is protective against Tau and Synuclein pathology! Check out the thread from fellow first-author @patwsheehan who spearheaded this awesome project
Pat Sheehan@patwsheehan
Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇
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@KeystoneSymp #KSNeurodegen23 #KSNeuroimmune23 was a fantastic experience! Seeing the forefront of groundbreaking research/therapy was incredibly heartening, and presenting our own was rewarding. Plus swam in a Canadian lake, had great food, and marveled at wondrous vistas
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Thrilled to find out that our prediction of BAG3 regulation of tau aggregation in astrocytes published in rdcu.be/c5gw5 has been validated by Collin Nadarajah @Neuro_Nada in the @ErikMusiek lab at #KSNeurodegen23 #KSNeuroimmune23 @KeystoneSymp poster presentation!
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@gzhao11 @ErikMusiek @KeystoneSymp @KeystoneSymp working as intended: connecting scientists and facilitating the sharing of cool science. Encouraging others found what we see! #KSNeurodegen23 #KSNeuroimmune23
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