Constantine

The deeper I dig into histamine, the more I recognize it’s probably the driver for a lot of dysfunctional behavior in people—ADHD, OCD, procrastination, insomnia, rumination. Histamine is one of the core arousal/wakefulness neurotransmitters and gates dopamine, acetylcholine, glutamate, and the stress axis via H1/H3 receptors. Too little histamine means underaroused; too much means hypervigilant. In cases of low-level (or even full-blown) allergies and dysregulated mast cell degranulation, chronic nighttime exposure leads to poor sleep. Downregulated H1 receptor expression from chronic agonism then causes poor activation when needed, leading to ADHD and/or procrastination—a functional histamine deficit. Similarly, chronic excessive histamine drive leads to OCD and rumination because the mind cannot relax in its hypervigilant state, which also causes histamine-driven insomnia. Two tools that can help: 1. Cyproheptadine is an antihistamine with antiserotonin effects that blocks histamine at the receptor and blunts the cortisol effect driven by excess serotonin (from gut microbes). It also stimulates appetite, so keep that in mind. More of a sledgehammer than... 2. Ketotifen, a mast cell stabilizer, doesn’t cause the drowsiness that cyproheptadine does. It prevents pathological mast cell degranulation and is good for low-grade allergies. And of course, the Ray Peat Carrot Salad™️ and well-cooked white button mushrooms will bind bacterial endotoxin in the gut, which could be driving the histamine dysfunction leading to the above symptoms.

This has a clinical name. Revenge bedtime procrastination. And the ADHD version runs on a completely different mechanism than the neurotypical one. A neurotypical person stays up late because they want more leisure time. The ADHD brain stays up because it spent every drop of dopamine it had on executive function during the day. Sitting in meetings, managing transitions, filtering impulses, remembering the thing you were supposed to remember. That burns through dopamine the way sprinting burns through glycogen. By 10pm the tank is empty. But here's where it gets counterintuitive. The exhaustion is physical. The dopamine deficit is neurological. Those are two separate systems. Your muscles want sleep. Your prefrontal cortex is starving for the stimulation it was denied all day because it spent 14 hours on task-switching and impulse control instead of anything that actually felt rewarding. The phone at midnight is the brain trying to collect what it's owed. Low-effort, high-stimulation content. Scrolling, short videos, rabbit holes. The exact profile of activity that delivers dopamine without requiring the executive function you already depleted. The sleep researchers call this a "self-regulation failure." It's closer to a debt collection. You borrowed against your own reward system to function all day. The bill comes due at midnight. And the brain will not let you sleep until it gets paid.

If you're in pure math and find yourself depressed, pivot to physics. We're on a journey to climb into the mind of God. It's bigger on the inside.

guys will turn 30 and start taking recoil damage when they sneeze

bro it isn’t generally intelligent bro its only read every book and paper ever written and just making connections between them bro. its only thinking for twenty hours bro it’s just brute force thinking bro. its only solving erdos problems bro it could never be an accountant bro

Microdosing hell by being aware and literate

No debt Ideal weight 8 hours of sleep Mental health on track Right nutrition Zero Alcohol This was my peak I was 8

After SpaceX' IPO, Elon will have 42% equity, and 69, no, 79% voting power. Elon is going to be supreme commander of the star fleet and emperor of the solar system

Being a highly intelligent outlier doesn't negate your ability to be retarded, paradoxically it actually enables far more creative ways of being retarded.

@iroasmas Toddlers are just tiny drunk people. No logic is at home. It’s all vibes.

If you're a millennial it's time to pick your midlife crisis: 1. Quitting alcohol 2. Running 10 miles before work 3. Divorce 4. Panic baby at 35 with wife you hate 5. Pickleball 6. ADHD diagnosis 7. Dressing like you did in 2004 8. Blacking out every weekend like you’re 21 9. Weekly hinge dates 10. Ice baths and saunas 11. Board games and craft beer in the suburbs 12. Getting into tattoos 13. Quitting your job to explore your “passions” 14. Plants and the environment 15. Traveling

the point of life is to do drugs in your room by yourself

@4TheGood1 @Too_Much_Reason @overton_news He can do that without making an example out of his "friend" lol

@Too_Much_Reason @overton_news How about using one of the biggest platforms on earth to warn about the dangers of something that is destroying millions of lives. I mean, heck - you’re a moron, but are you really that big of a retard too?

Joe Rogan just took time out of his podcast to express genuine concern for his friend Theo Von. He admitted that some of Von’s recent behavior after getting on SSRIs “freaks me out” — especially his comments about suicide. ROGAN: “Theo Von’s going through the exact same thing and last time he was on the podcast he was explaining it to me.” “It freaks me out because I know Theo has had conversations before...like even publicly.” “He had a Netflix taping and it didn’t go well. It was like they actually never...they shelved it. They never used it.” “And you know there was all these stories from people that were there saying he bombed. I think he just had a kind of a breakdown.” “And when he was talking to the crowd and there’s a video of it, he said, you know, the people were saying, hey, we still love you.” “He goes, thank you. Look, I’m just I’m trying not to take my own life.” “And like you hear stuff like that and you just go like, oh, Jesus Christ.” “I’ve known too many people that I didn’t think were going to kill themselves and then did.” “And then he goes down these spirals where he starts talking about world events and freaking out. I’m like, oh, Jesus Christ! Like, I got to help this dude.”

“I cannot remember the books I've read any more than the meals I have eaten; even so, they have made me.” ― Ralph Waldo Emerson

You only live once, so make sure to spend as much time as possible on your computer. You won’t have access to it when you die

@RyanGarcia That's how much I make in a year 🥲

Since I won 120,00 I’ll give one person 10k who likes this tweet and follows me. Let’s go

@RyanGarcia Dont really like my chances 😅

I’ll pick by Monday

@aakashgupta this might be the single best explanation of survivorship bias I've ever read. the red dots aren't a blueprint they're the result of a filter.

Stephen Wolfram, founder of Wolfram Research, explains how LLMs are quietly dismantling our deepest assumptions about consciousness: He argues that large language models have done something philosophy and neuroscience couldn't: "In terms of consciousness, I have to say, the idea that there's sort of something magic that goes beyond physics that leads to sort of conscious behavior, I kind of think that LLMs kind of put the final nail in that coffin." His reasoning is that LLMs keep doing things people assumed they couldn't: "There were all these things where it's like, oh, maybe it can't do this, but actually it does. And it's just an artificial neural net." Wolfram then challenges a core assumption about conscious experience: the feeling that we are a single, continuous self moving through time. "I think our notion of consciousness is a lot related to the fact that we believe in the single thread of experience that we have. It's not obvious that we should have a persistent thread of experience." He points out that physics doesn't actually support this intuition: "In our models of physics, we're made of different atoms of space at every successive moment of time. So the fact that we have this belief that we are somehow persistent, we have this thread of experience that extends through time, is not obvious." Then Wolfram offers a striking origin story for consciousness itself. @stephen_wolfram suggests it traces back to a simple evolutionary pressure: the moment animals first needed to move. "I kind of realized that probably when animals first existed in the history of life on Earth, that's when we started needing brains. If you're a thing that doesn't have to move around, the different parts of you can be doing different kinds of things. If you're an animal, then one thing you have to do is decide, are you going to go left or are you going to go right?" That single binary choice, he argues, may be the seed of everything we now call awareness: "I kind of think it's a little disappointing to feel that this whole wanted thing that ends up being what we think of as consciousness might have originated in just that very simple need to decide if you are an animal that can move. You have to take all that sensory input and you have to make a definitive decision about do you go this way or that way." The takeaway is unsettling but clarifying. If LLMs can produce complex behavior from simple rules, then consciousness may not be a mystical add-on to physics. It may just be what happens when a layered enough system has to make a decision.

@kirawontmiss This is 99% fake dude

"You want to really make a pandemic, make hantavirus human transmissible" > posted in 2012