Trends in Psychiatry

Preventing Suicide by Professor Rob Poole, Professor Murad M. Khan and Professor Catherine A. Robinson A succinct, evidence-based, and practical guide to suicide prevention from a multicultural and international standpoint. 📚 cup.org/4eQepvC

Psychedelics as a potential treatment for borderline personality disorder: A narrative review #mentalhealth sciencedirect.com/science/articl…

Predicting early clinical recovery in first-episode psychosis: development and external validation of a clinically interpretable multivariable model #mentalhealth cambridge.org/core/journals/…

Non-suicidal self-injury in adolescents and the influence of memetics #mentalhealth sciencedirect.com/science/articl…

🚨 Medical history rewritten: 19-year-old becomes the youngest person diagnosed with Alzheimer's. In a medical first that has stunned the scientific community, doctors have diagnosed a 19-year-old with Alzheimer’s disease, marking the youngest confirmed case in history. His symptoms began at just 17 with concentration issues and reading difficulties, eventually progressing to severe memory loss where his recall scores were over 80% lower than his peers. Most strikingly, the teenager possessed no known genetic mutations or family history of the disease, defying the usual patterns found in early-onset cases which typically involve inherited triggers. The diagnosis was confirmed through brain scans showing damage to the hippocampus and spinal fluid tests revealing classic Alzheimer’s biomarkers. This case disrupts the traditional understanding of the disease as one reserved for the elderly or those with rare genetic predispositions. Researchers now believe that unknown biological pathways may trigger the condition, suggesting that Alzheimer’s can manifest much earlier than previously imagined. This discovery opens a challenging new frontier in neurology, demanding a re-evaluation of how the disease develops across different age groups. Source: Jia, J., Zhang, Y., Shi, Z., Yin, R., Wang, S., & Ji, Y. A 19-Year-Old Patient with Probable Alzheimer's Disease. Journal of Alzheimer's Disease.

In this meta-analysis, patients with Bipolar Disorder who were treated with lithium had a 49% lower risk of developing dementia compared with patients with Bipolar Disorder who were not treated with lithium @chrisaikenmd @CarlatPsych pubmed.ncbi.nlm.nih.gov/31954065/

Papageno Stories Predict Lower Suicide Rates – Analysis of American Feature Films, 1950–2002: A Research Note #mentalhealth econtent.hogrefe.com/doi/10.1027/02…

Feasibility of Katatagan Plus as a mental health early intervention for at-risk youth #mentalhealth tandfonline.com/doi/abs/10.298…

Clinical investigation of postpartum depression risk factors and screening predictors #mentalhealth wjgnet.com/2220-3206/full…

Efficacy and Acceptability of Licensed and Off‐Label Pharmacological Interventions for Insomnia in Patients With Severe Mental Illness: A Systematic Review and Meta‐Analysis of Randomised Trials #mentalhealth onlinelibrary.wiley.com/doi/10.1111/ac…

Insight differences between deficit and non-deficit schizophrenia: a systematic review and meta-analysis #mentalhealth sciencedirect.com/science/articl…

Integrating Cobenfy Into Clinical Practice #mentalhealth psychiatryonline.org/doi/10.1176/ap…

Camouflaging is when people on #autism spectrum mask symptoms or imitate normal interactions to avoid standing out. It can work, but it's also a cause of distress, as new study finds: pubmed.ncbi.nlm.nih.gov/41120451 How do you manage this side effect of social skills training?

1/ Highlights from this crucially important paper: About 7 out of 10 patients who get “evidence-based therapy” for depression are still depressed after treatment Of the 3 that get well, about half would have gotten well without treatment No significant differences between types of therapy (the “dodo bird verdict”) “Third wave” therapies (eg, ACT) no better than plain old CBT, or any other form of treatment From the paper: “Most patients do not respond or remit after therapy, and more effective treatments are clearly needed” So… can someone please explain to me again why these treatments are routinely called “evidence-based therapy?”

Yet more evidence that haloperidol is not a sedative. RCT to ⬇️ agitation in palliative care #delirium 1⃣haloperidol 2⃣lorazepam 3⃣halop + loraz 4⃣placebo Haloperidol monotherapy was not more efficacious than placebo in reducing RASS. doi.org/10.1001/jamaon…

Scrolling through adolescence: a systematic review of the impact of TikTok on adolescent mental health #mentalhealth link.springer.com/article/10.100…

Perception of depressive and suicide memes with different types of punchlines by persons with low or high suicide risk #mentalhealth europeanjournalofhumour.org/ejhr/article/v…

A proxy measure of clinical insight in psychosis: an electronic health records-based validation study cambridge.org/core/journals/…

Impact of maternal stress and COVID-19 exposure during pregnancy on offspring neurodevelopment: signature cohort 12 month follow-up #mentalhealth link.springer.com/article/10.100…

Maternity in women with schizophrenia and schizoaffective disorder #mentalhealth sciencedirect.com/science/articl…