Afif Pranaya Jati

.@afifpj (@MonashBDI) and colleagues published a new paper in npj Viruses on how highly stable #phages PIN1 and PIN2 have hallmarks of flagellotropic phages but infect immotile bacteria. buff.ly/ntlwryc

@SerieA_Lawas Bapaknya pemain Juve

Skuad juara AC Milan tahun 1999. Bisa dibilang, AC Milan 98/99 itu definisi juara itu yang raih peringkat 1 di akhir musim. Sepanjang musim, AC Milan baru berhasil jadi capolista menjelang akhir2 musim. Coba tebak, siapa pemain Milan yg tertutup emoticon pada foto di bawah?

Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential biorxiv.org/content/10.110… #biorxiv_micrbio

Want to find new lytic phages .... then obviously look in bacterial genomes !!! Led by @TSPKU , with @MarthaClokie @panagouras3 , @bentpetersen and many many others... biorxiv.org/content/10.110…

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance | Nature Communications nature.com/articles/s4146…

This isn't science fiction. This is real sequencing biotechnology just introduced by Roche. Wild and wonderful.

Extremely clever new NGS tech from Roche 🧬 If it's hard to discriminate between nucleic acids accurately with a nanopore, why not synthesize a new polymer off a DNA template that is easier to sequence? It's an intuitively simple idea, but took *a ton* of creative nucleic acid chemistry + enzyme engineering to design modified NTPs and create polymers of them. It's been very interesting to see Roche move into the NGS market, and time will tell how this stacks up with the growing set of totally orthogonal approaches people are cooking up for sequencing tech. It feels like we are entering another renaissance for biological measurement infrastructure—which is super important. “Progress depends on the interplay of techniques, discoveries, and ideas, probably in that order." - Sydney Brenner (These animations of sequencing tech will never get old to me. What a time to be a biologist!)

LoVis4u: a locus visualization tool for comparative genomics and coverage profiles | NAR Genomics and Bioinformatics | Oxford Academic academic.oup.com/nargab/article…

I am happy to tell that our collaborative review article on #PhageTherapy has been just published in Nature Reviews Methods Primers rdcu.be/d9H92

K. variicola can be misidentified as K. pneumoniae. Our #OpenAccess paper reports an outbreak in the NICU 📌The rapid detection of a neonatal unit outbreak of a wild-type Klebsiella variicola using decentralized Oxford Nanopore sequencing | @ARICJournal doi.org/10.1186/s13756…

xOmicsShiny: an R shiny application for cross-omics data analysis and pathway mapping biorxiv.org/content/10.110… #Rstats 🧬🖥️🧪 github.com/interactiverep…

🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵

genomics- A collection of scripts and notes related to genomics and bioinformatics github.com/igordot/genomi…

Our recently work shedding light on the reason why most OAg in E. coli favoured the initial sugar with GlcNAc same to ECA structure is out! It is like a plumbing solution to ensure efficient recycling of the essential cell envelope building block, UndP journals.plos.org/plosgenetics/a…

Our study appearing in @NatureComms showing the importance of the T6SS of Klebsiella pneumoniae in gut colonization. We combined tn-seq with metagenomics and identified new microbiota targets and T6SS regulators. nature.com/articles/s4146…

Enterobacterales with OXA-48-like carbapenemases are undermining the efficiency of carbapenem therapy. This review in @JClinMicro describes the genomic aspects underlying the rapid global spread of these organisms, and why they have become so successful. asm.social/2fx

Mining biology for antibiotic discovery journals.plos.org/plosbiology/ar… 🧬🖥️🧪

Engineering Phages to Fight Multidrug-Resistant Bacteria summarizes phage engineering techniques pubs.acs.org/doi/10.1021/ac…

Antibiotics that Kill Gram-negative Bacteria by Restructuring the Outer Membrane Protein BamA biorxiv.org/cgi/content/sh… #biorxiv_micrbio

From phenotype to receptor: validating physiological clustering of Escherichia coli phages through comprehensive receptor analysis biorxiv.org/cgi/content/sh… #biorxiv_micrbio