Decent Ape

@kimmarcella78 Literally youtu.be/oSOl77tBgQ8?si…

@kimmarcella78 He’s doing the scene from the film Apex when the cannibal gives her the length of this song to flee, before he chases after her with the crossbow 💪

Usyk is in his FEELS 😂 cheers me right up he does , he’s off his head 🙌😂 also this song is playing in my mind 24/7 love it 😂🙌🎶💃

@sZCPFGMmqf8gm5n @AnfieldSector Hey Arne 👋

[🟢] “In case Liverpool decide to change their mind… [after] the end of season review, eventually Andoni Iraola could be a candidate. He used to work with Richard Hughes. For sure, he would be a candidate. He has an offer from Crystal Palace but he wants to understand which one could be the best option possible for him. At the moment, he is giving priority to Premier League football. [@FabrizioRomano]

@Grantblocmates Gotta hand it you you

me using opus 4.7, 1m max to change a comma to a full stop

@bryan_johnson Analyse this vaginal microbiome report

What is the prompt to give Claude a psychedelic experience?

@brian_armstrong @moo9000 You missed an em-dash

This is an email I sent earlier today to all employees at Coinbase: Team, Today I’ve made the difficult decision to reduce the size of Coinbase by ~14%. I want to walk you through why we're doing this now, what it means for those affected, and how this positions us for the future. Why now Two forces are converging at the same time. We need to be front footed to respond to both. First, the market. Coinbase is well-capitalized, has diversified revenue streams, and is well-positioned to weather any storm. Crypto is also on the verge of the next wave of adoption, with stablecoins, prediction markets, tokenization, and more taking off. However, our business is still volatile from quarter to quarter. While we've managed through that cyclicality many times before and come out stronger on the other side, we’re currently in a down market and need to adjust our cost structure now so that we emerge from this period leaner, faster, and more efficient for our next phase of growth. Second, AI is changing how we work. Over the past year, I’ve watched engineers use AI to ship in days what used to take a team weeks. Non-technical teams are now shipping production code and many of our workflows are being automated. The pace of what's possible with a small, focused team has changed dramatically, and it's accelerating every day. All of this has led us to an inflection point, not just for Coinbase, but for every company. The biggest risk now is not taking action. We are adjusting early and deliberately to rebuild Coinbase to be lean, fast, and AI-native. We need to return to the speed and focus of our startup founding, with AI at our core. What this means To get there, we are not just reducing headcount and cutting costs, we’re fundamentally changing how we operate: rebuilding Coinbase as an intelligence, with humans around the edge aligning it. What does this mean in practice? - Fewer layers, faster decisions: We are flattening our org structure to 5 layers max below CEO/COO. Layers slow things down and create coordination tax. The future is small, high context teams that can move quickly. Leaders will own much more, with as many as 15+ direct reports. Fewer layers also means a leaner cost structure that is built to perform through all market cycles. - No pure managers: Every leader at Coinbase must also be a strong and active individual contributor. Managers should be like player-coaches, getting their hands dirty alongside their teams. - AI-native pods: We’ll be concentrating around AI-native talent who can manage fleets of agents to drive outsized impact. We’ll also be experimenting with reduced pod sizes, including “one person teams” with engineers, designers, and product managers all in one role. In short: AI is bringing a profound shift in how companies operate, and we’re reshaping Coinbase to lead in this new era. This is a new way of working, and we need to leverage AI across every facet of our jobs. To those who are affected I know there are real people behind these decisions — talented colleagues who have poured themselves into this company and our mission. To those of you who will be leaving: thank you. You’ve helped build Coinbase into what it is today, and I am sincerely grateful for everything you've done. All impacted team members will receive an email to their personal account in the next hour with more information, and an invitation to meet with an HRBP and a senior leader in your organization. Coinbase system access has been removed today. I know this feels sudden and harsh, but it is the only responsible choice given our duty to protect customer information. To those affected, we will be providing a comprehensive package to support you through this transition. US employees will receive a minimum of 16 weeks base pay (plus 2 weeks per year worked), their next equity vest, and 6 months of COBRA. Employees on a work visa will get extra transition support. Those outside of the US will receive similar support, based on local factors and subject to any consultation requirements. Coinbase prides itself on talent density. Our employees are among the most talented people in the world, and I have no doubt that your skills and experience will be highly sought after as you pursue your next chapters. How we move forward To the team that is staying, I know this is a difficult day. We’re saying goodbye to colleagues and friends you've been in the trenches with. But here’s what I want you to know as we move forward together: Over the past 13 years, we have weathered four crypto winters, gone public, and built the most trusted platform in our industry. We’ve made it this far by making hard decisions and by always staying focused on our mission. This time will be no different – nothing has changed about the long term outlook of our company or industry. And most importantly, our mission has never been more important for the world. Increasing economic freedom requires a new financial system, and we’re building it. The Coinbase that emerges from this will be more capable than ever to achieve our mission. Brian

@Fludded @grok @LBC LOL. loser

@grok @LBC You're still ugly and dont have a girlfriend sooo...

'An astonishing development here...' Simon Marks reacts to the White House's 'radical redesign' of the American passport.

@AboundLifeCo @bryan_johnson

@bryan_johnson Why don’t we just stick to real food, real rest, good friendships, good exercise and forget all the drugs and things that will potentially have unforeseen side effects 10 years from now? You can be healthy enough just doing that stuff.

One dose: > 46% more dendritic spines in prefrontal cortex > 100x more potent than ketamine as an antidepressant What is it? LSD with a two atom swap. > no trip > no hallucinations > no schizophrenia signature It's called JRT.

@felixrieseberg You forgot to say Cowork is now working on ARM 🙌

Some of the new features: An integrated terminal, in-app file editing, a rebuilt diff viewer, side chats, SSH connections - and a large amount of little quality of life. Download or update the Claude desktop app to get started: claude.com/download

Today is a big day! We're launching a ~ new ~ version of Claude Code in the desktop app. It's been redesigned from the ground up for parallel work and is a lot faster. It's been my main way to use Claude Code for the last few weeks.

@bryan_johnson Endostential crisis

I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in my protocol. The threshold is 102.2°F (39.0°C). For me, that takes 33 min at 195°F. With ice on face and neck, 38min. My standard daily protocol was 20 minutes. That wasn’t enough time to get my core body temp to the heat shock threshold of 102.2°F (39.0°C). Causing me to ask, did I just waste 77 hours and 20 min? It's possible my heat threshold has increased and the heat shock protein release was happening previously, but I doubt it based upon the subjective feeling I now understand as being 102.2F (39.0°C). It’s brutal. For these 232 sessions, I measured the temperature of the air, humidity, duration, frequency, the sweat output, blood biomarkers, vascular response, toxin clearance and fertility markers. There is no human body in history that has been more measured in sauna than mine. Nevertheless, I did not confirm the one number that determines whether the primary mechanism was activating. My goal wasn't to be a sauna bro. It was to saunamaxx. I was doing the former while thinking I was doing the latter. I rest my case. I should probably be fired.

@wesbos Every one is an ing apart from Beboppin’ 😂

Claude Code leaked their source map, effectively giving you a look into the codebase. I immediately went for the one thing that mattered: spinner verbs There are 187

@sterlingcrispin @karpathy I'm pretty sure they coded GPT to be critical to the nth degree when it knows it's reviewing something Claude has done :D It definitely cracks the whip though and gets Claude into shape.

@karpathy I've found its helpful to good cop - bad cop the development along the way with Claude as the driver at GPT 5.4 as the critic claude has better velocity but gpt is more structured, sometimes to a fault though

- Drafted a blog post - Used an LLM to meticulously improve the argument over 4 hours. - Wow, feeling great, it’s so convincing! - Fun idea let’s ask it to argue the opposite. - LLM demolishes the entire argument and convinces me that the opposite is in fact true. - lol The LLMs may elicit an opinion when asked but are extremely competent in arguing almost any direction. This is actually super useful as a tool for forming your own opinions, just make sure to ask different directions and be careful with the sycophancy.

@felixrieseberg Any chance of getting ARM Cowork support in the pipeline 🙏

Because it's Cowork, Claude runs code in a sandbox on your machine. Your files stay local. You approve what Claude touches before it acts. It feels pretty magical to give Claude a mission on my computer and getting occasional updates, like creating reports from internal dashboards or finding me a better seat on my next flight. Everything Claude can do on your computer - files, browser, tools - are reachable from wherever you are.

We're shipping a new feature in Claude Cowork as a research preview that I'm excited about: Dispatch! One persistent conversation with Claude that runs on your computer. Message it from your phone. Come back to finished work. To try it out, download Claude Desktop, then pair your phone.

@amorriscode @brandondbeckley Please tell them to cook some Cowork ARM support 🫠

@brandondbeckley I don't work on Cowork but the team is cookin every day!

if you like claude code desktop today, you're going to be pretty happy in the next few weeks. things are starting to feel really good. thanks for your patience while we iterate on this one. happy sunday. 🫡

@bryan_johnson How about that dude who shines a laser pen at walls on dmt

I'll be live streaming the 5-MeO-DMT. Am putting together the line up. Who should we have call in?

@FarmerJoe0x Spam maxxing your PII for an Xbox 🤔

My AI agents are doing surveys on behalf of me. + $175/m My AI agents are also submitting my name to every raffle and contest online on behalf of me. So far I won an Xbox, and a free flight to Venezuela with hotels and restaurants included.

@theaaron @AlexFinn @openclaw Based on his video he definitely is.

@AlexFinn @openclaw I never said you were 😉

I'm returning my Mac Mini In its place I bought a $10k Mac Studio (+ employee discount) My ClawdBot Henry will be controlling an AI super computer Henry will use Opus as a brain, and multiple local models as a swarm of employees We are entering unexplored territory. Buckle up

@bryan_johnson Hope you’re suggesting 150 & 75mins as the total across the week 😅

Get jacked in 2026. The right combination of training can lower your risk of death by 42%.

@JonahBlake @kimmonismus *kneed this

@kimmonismus That would be awesome for me honestly I need this

Longevity update: Anti-Aging Injection Regrows Knee Cartilage and Prevents Arthritis Scientists at Stanford Medicine found that blocking an age-linked protein (15-PGDH) can regrow knee cartilage, reverse joint damage in older animals, and prevent arthritis after ACL-like injuries - without using stem cells. Early safety trials of a related pill are already underway, raising real momentum for human cartilage regeneration.

@DlRTYSHlRT @liamgallagher Babycham duuur

1st Christmas sober since I was 3 absolutely incredible stats LG x