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#FirstPaper ! 🍾😀💫 Molec. principles of gene fusion-rewired PPI nets in cancer cell.com/molecular-cell… @MRC_LMB @MolecularCell HT @naivelocus
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Louis Maddox
16.6K posts
Louis Maddox
@biochemistries
Bio,chem,code∈combiℕatorics. ML & systems biology. Sci paper feed @naivelocus, tech alt. @permutans, & maths papers @appendens.
London, England Katılım Aralık 2013
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Louis Maddox retweetledi
Tasmanian devils’ contagious facial cancers sequenced for first time go.nature.com/3n9nU0J
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Potential differences in ion density can occur not just across PL membranes but on microdroplets of water and air, including it turns out biological condensates, driving redox doi.org/10.1016/j.chem…
Phys.org@physorg_com
Newly discovered electrical activity within cells could change the way researchers think about #biologicalchemistry doi.org/gr6sk6 phys.org/news/2023-04-n…
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Louis Maddox retweetledi
Hey, weren't you a co-author on that?
nature.com/articles/s4158…
Yes, I was, but the Nature editors neutered the letter to the point that I felt I could no longer in good conscience put my name on it. The most egregious (and final straw for me) was the insistence to change 1/n
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Louis Maddox retweetledi
Pretty awesome survey of what ChatGPT can do: arxiv.org/abs/2303.13528. We've changed our graduate bioinformatics class to allow/encourage LLMs, it's nice to be able to focus on the bigger picture in homework questions (+ edge cases).
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Comparison of 1,800 de novo vs. 1,800 randomly computer generated proteins found they are moderately more soluble, despite similar structural potential/protease resistance after controlling for AA freq/length phys.org/news/2023-04-d…
📄 Heames et al. (2023) dx.doi.org/10.1038/s41559…
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✍️ The seahorse has two tendons that allows it to lift its head and suck in prey at high speed phys.org/news/2023-04-s…
📄 A power amplification dyad in seahorses (2023) dx.doi.org/10.1098/rspb.2…
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Louis Maddox retweetledi
Naming system for #transferRNA fragments to increase research productivity, standardization @naturemethods doi.org/gr4xf4 phys.org/news/2023-04-r…
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“[Smart Immune]’s experimental cancer trial, hop[es] its novel technology will one day allow HIV patients to rebuild their immune system” — Gates Fdn. usually funds ID but is funding early stage trial in leukaemia patients after chemotherapy, could also improve CAR-T
FT for Schools@ft4s
Gates Foundation makes unusual investment in experimental cancer trial on.ft.com/3L560FF
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Louis Maddox retweetledi
expert reaction to reports that £1.6 Billion of R&D funding has been returned to the Treasury
sciencemediacentre.org/expert-reactio…
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Louis Maddox retweetledi
NEW: CRISPR pioneer Feng Zhang is building a secretive new startup to solve gene-editing's biggest problem — getting into more parts of the body
Meet Aera Therapeutics, which has raised $200 million to advance Zhang's work: businessinsider.com/exclusive-new-…
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Louis Maddox retweetledi
Booking for boosters 50-64s officially opens tomorrow.
If you’re in that age-range, it might just be worth ignoring the front page text and trying the link now. nhs.uk/conditions/cor…
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Louis Maddox retweetledi
ProtNLM (Protein Natural Language Model) annotates previously "uncharacterised proteins" in @uniprot in English
Instead of a restricted tag set, it predicts function as language:
[amino acids] -> "CRISPR-associated endonuclease Cas9"
Collaboration between @GoogleAI and @emblebi
EMBL-EBI@emblebi
Ever got a result back saying uncharacterised protein? 😩 @uniprot and @GoogleAI have teamed up to create a natural language processing model that has generated over 40 million protein annotations to address this challenge. ebi.ac.uk/about/news/tec…
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Louis Maddox retweetledi
.@CDCgov releases very preliminary analysis that suggests the #monkeypox vaccine is offering protection after a single dose. But outside experts urge the finding should be interpreted with a lot of caution. statnews.com/2022/09/28/ear…
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Louis Maddox retweetledi
"We discovered a simple peptide that inhibits
infection by all major variants of #SARSCoV2 with nanomolar efficacies."
pnas.org/doi/10.1073/pn…
@PNASNews @emkailu @StanfordMed @HHMINEWS
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Louis Maddox retweetledi
Why do birds have different eye colors? The short answer is we don't know. The long answer is in our new review article, up now as a preprint! We look at the pigments, genes, and evolutionary forces that give birds eyes their colors. ecoevorxiv.org/5h4pk/
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Louis Maddox retweetledi
It's sobering that, globally, we are not able to produce enough supply of smallpox vaccine at pace to meet the demand for monkeypox control. Many countries with hundreds (or thousands!) of cases have not even started vaccinating yet, let alone launched a vaccination strategy.
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Louis Maddox retweetledi
1. There's a new #monkeypox technical brief out from @UKHSA. Always an interesting read.
A 🧵
HSA's modeling suggests the outbreak isn't expanding, though they acknowledge cases are certainly being missed and that makes it hard to accurately gauge things.
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Louis Maddox retweetledi
Want to tinker with the 200M+ protein structures from AlphaFold in your favorite DataFrame format (pandas!)⁉️
Thanks to a kind contribution by @arian_jamasb, this is now possible in the latest BioPandas dev version as of this morning!
github.com/rasbt/biopandas
Demis Hassabis@demishassabis
A year ago we open-sourced #AlphaFold Today we're freely sharing the predicted structures of all 200M+ proteins known to science - almost the entire protein universe! It's our gift to humanity, and a demonstration of the benefits AI can bring to society dpmd.ai/AF-22-LI
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