Daniel Lüdke

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Daniel Lüdke

Daniel Lüdke

@daniel_luedke

🌱Plant Biologist🌱 Post-doc @TheSainsburyLab | he/him |

Norwich, UK Katılım Temmuz 2017
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Daniel Lüdke
Daniel Lüdke@daniel_luedke·
Some predictions are high-confidence. These go to eleven! Huge congrats to the whole team ❤️ Such a privilege to work with you all.
AmirAli Toghani@amiralito_

Protein structure prediction changed biology. Protein assembly discovery is next. We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes. We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻 biorxiv.org/content/10.648…

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Sophien Kamoun
Sophien Kamoun@KamounLab·
This is the culmination of >10 years of work by generations of students and postdocs. Many false starts. And we know that others have tried too. Structural insights into the activate-and-release mechanism of NLR activation. And we can engineer it too! Kudos Team 🙏🔥
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Mauricio Contreras@mpcontreras4

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.648…

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Maián
Maián@mai_garro·
Can we rewire how plants fight disease? We used AF3 to predict, validate, and engineer a sensor–helper interface that escaped biochemistry for years 🤯 Grateful to @mpcontreras4 & @KamounLab for trusting me to be part of this story. Full story below 👇🏻
Mauricio Contreras@mpcontreras4

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.648…

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Mauricio Contreras
Mauricio Contreras@mpcontreras4·
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.648…
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Vivek Natarajan
Vivek Natarajan@vivnat·
Neat use of @GoogleDeepMind AI Co-Scientist and AlphaFold 3 from @amiralito_ @KamounLab @TheSainsburyLab They discovered a massive potato immune protein (an 11-mer resistosome) with Co-Scientist suggesting new structural clues that helped the team hunt this down. Exciting leap forward in decoding plant immunity with implications for global food security.
AmirAli Toghani@amiralito_

Protein structure prediction changed biology. Protein assembly discovery is next. We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes. We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻 biorxiv.org/content/10.648…

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The Sainsbury Laboratory
The Sainsbury Laboratory@TheSainsburyLab·
New Preprint in collaboration with @GoogleDeepMind: AI-guided discovery of atypical protein assemblies The @kamounlab discovered an 11-protomer complex through the Structural Novelty Index , a new way to use AlphaFold for atypical protein assemblies buff.ly/GsF3zve
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Pablo del Cerro
Pablo del Cerro@pabdelcer·
Thank you so much! Really honored to receive this award. This is truly special for me. Since my MSc I started attending @SEFIN_esp conferences, which positively influenced my research career. Looking forward to seeing you all in Cádiz for our next meeting! 🧬🌱🍻
Sociedad Española de Fijación de Nitrógeno@SEFIN_esp

📢Nos complace anunciar que @SEFIN_esp otorga el VIII Premio Antonio Palomares al Dr. Pablo del Cerro Sánchez @pabdelcer por su excelente carrera profesional y relevantes contribuciones científicas en el ámbito de las interacciones beneficiosas planta-microorganismo ¡Enhorabuena!

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Sophien Kamoun
Sophien Kamoun@KamounLab·
Just published: Breaking the Pattern with AlphaFold: Introducing the Structural Novelty Index AlphaFold has transformed how we predict protein structures. But sometimes the most interesting discoveries come from asking a different question: which proteins break the pattern? medium.com/p/breaking-the…
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AmirAli Toghani
AmirAli Toghani@amiralito_·
UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥 Rings ~250 Å across — way bigger than canonical hexamers (~150 Å). 11 protomers. (5/n)
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Tarhan Ibrahim
Tarhan Ibrahim@TarhanEI·
Our NRG1 story is out now in @ScienceMagazine! science.org/doi/10.1126/sc… Also check out this news letter from @imperialcollege @BezosCentre for a nice summary! imperial.ac.uk/news/news/arti… A great team effort @Tolga_Bzkrt @KamounLab @JiorgosKourelis @jonathandgjones @AdamWu9527
Tarhan Ibrahim@TarhanEI

🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…

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Tarhan Ibrahim
Tarhan Ibrahim@TarhanEI·
🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…
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Tolga Bozkurt
Tolga Bozkurt@Tolga_Bzkrt·
Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc…
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Tarhan Ibrahim@TarhanEI

🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…

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JC De la Concepción
JC De la Concepción@delaconcepcionj·
Extremely honoured to receive one of the @BiochemSoc Early Career Research Award!
Biochemical Society@BiochemSoc

Demonstrating exceptional originality across multiple research fields, we are excited to present Juan Carlos De La Concepcion with an Early Career Research Award in 2026! @delaconcepcionj has made fundamental discoveries in plant immunity & the biology of immune receptor function

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Daniel Lüdke
Daniel Lüdke@daniel_luedke·
We conclude that autoactive NRC helpers function independently of upstream sensors like Prf. In other words, the NRC network is unidirectional—once a helper is (auto)activated, it can induce cell death and does not depend on a sensor NLR.
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Daniel Lüdke
Daniel Lüdke@daniel_luedke·
NEW! A short update on plant immunity - Do autoactive helper NLRs of the NRC phylogenetic clade require the sensor NLR Prf to induce hypersensitive cell death? We think: No The NRC network is unidirectional and autoactive NRC helpers do not depend on sensors for their activities.
bioRxiv Plant Bio@biorxiv_plants

The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in prf mutants of Nicotiana benthamiana biorxiv.org/content/10.110… #biorxiv_plants

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Keşfet

@mpcontreras4 @KamounLab @ScienceMagazine @theNASciences @ISMPMI @GoogleDeepMind @amiralito_ @TheSainsburyLab