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@ghostfeet30

Katılım Mart 2026
47 Takip Edilen0 Takipçiler
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Sean X. Luo MD PhD
Sean X. Luo MD PhD@seanluomdphd·
No. I think people deserve to know how these things work before you poh on them. I'm sure you know much of this, but the general public does not. There are hundreds of so called "rare variants" of which if you develop something through idiosyncratic mutation ("de novo" as opposed to "germline") which drop your IQ by a substantial amount. This explains almost all of the variance between fraternal siblings. Prior PGS before deep sequencing only identifies common variants, which do not contain useful information, because in general fraternal siblings do not have a lot of variability in their common variant background, which represent their common *ancestral* genetic lineage, and even if they do it's minimally informative on an individual basis. However, things changed in the last 5 years where suddenly a huge amount of deep exome sequencing data emerged, and hundreds of new rare variants are identified, such that the so called "missing variance" that is estimated in twin studies is no longer missing if you tabulated all the rare variants. An intuitive way to think about this is that rare variants are like harmful switches that drop your IQ. And the screens find them if they exist, and hence optimizes offspring IQ within a cohort of possible siblings. The effect of this depends on the common variant background but can be quite substantial. The real controversy is how MUCH that effect is related to the present ancestral background. I.e. if your common variants say you are gonna be IQ 100, even if you don't have any of the harmful rare variants, maybe it won't make much of a difference if you detected a couple. And there are yet not understood nonlinear interactions between common and rare variants, and people are working on this with ML. Also many of us have these rare variants and perhaps have lower IQ than we are "supposed" to have, another poorly understood finding. Nonetheless, the new results are genuinely new and impactful. This is also the same architecture, for highly heritable but "polygenic" psychiatric traits like schizophrenia and autism, and explains much of the "missing variance" in the prior PGS studies. But there seems to be less controversy surrounding the same techniques optimizing for those traits.
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3c685ab5014bb3d
3c685ab5014bb3d@3c685ab5014bb3d·
@GeneSmi96946389 I fucking love those Internet IQ discussions, SD value or scale name never provided, it's like talking about ambient temperature with Americans, eh.
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Gene Smith
Gene Smith@GeneSmi96946389·
A friend of mine had her embryos screened by Herasight and they found one with an IQ score in the 99.99th percentile
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Hunter Ash
Hunter Ash@ArtemisConsort·
Mussolini’s last words: “shoot me in the chest” Teddy Roosevelt: gave an hour-long campaign speech with an assassin’s bullet still in him Countless Roman generals: fell on their swords in defeat Dork-ass TV writer: “powerful men all turn into pussies like me when threatened”
Hunter Ash@ArtemisConsort

This is “art” made by resentful creatives with no exposure to actual powerful people. In reality, powerful people are generally quite internally strong. That’s how they became powerful. Art should be true.

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sy
sy@seezyou·
RESIST the urge to teach anything to anyone unless you’re asked.
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Piers Plowman
Piers Plowman@pierslangland·
@justalexoki Accept that it was impossible for it to be otherwise because we are all just spacetime worms in the eternal geometry of the universe which is a 4D spacetime block.
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taoki
taoki@justalexoki·
what if u made a really big mistake somewhere in the past and ur not where ur supposed to be
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Solo stan 𓅓
Solo stan 𓅓@ShadyChampagne·
@Angry_Crow24 This is cap, and I've studied Fortnite ass for years. Tracer got a taller ass, But Chun-Li still got the biggest ass in Fortnite. Tracer has the better pants tho, its shiny and goes inside the crack for a better look
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ghost
ghost@ghostfeet30·
@ScoutSzewc @StriderCaptain @punishednuz calling it "transphobia" or "bigotry" skips the whole point. the edits went viral because they show the comic reads cleaner without the extra text and when the artist publicly replies by saying people should feel shame, of course the argument keeps going lol
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Scout Szewc
Scout Szewc@ScoutSzewc·
@ghostfeet30 @StriderCaptain @punishednuz Ok i'll go along with this bs and say the critiques are valid. Alright then why have people done this editing thing for months on end? She got the point after the first round of harrassment. The only reason to continue this is pure bigotry
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nuz
nuz@punishednuz·
this is a different joke
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Scout Szewc
Scout Szewc@ScoutSzewc·
@StriderCaptain @punishednuz It's all trasphobia. They don't give a shit about haus's work or schulz's work. They just want to harrass her and see if maybe they can get her to leave the platform or something
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taoki
taoki@justalexoki·
what do people talk about if it's not sex or computers or God
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alex
alex@vaudevillehook·
Now if I were the clit where would I be…
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Not Samantha A
Not Samantha A@Samhain948689·
@justalexoki actually pure mathematicians are even worse since they often think about things that are not of the world and never will be. absolute perverts.
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ghost
ghost@ghostfeet30·
@ReverendNutria @escapefrommelos you don’t need mind-body dualism to argue your point. transgender individuals have different neurobiology
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The Earl of Nutria
The Earl of Nutria@ReverendNutria·
@escapefrommelos When you believe in mind-body dualism, your internal image is totally independent & more reflects the real you than what your actual image is. Therefore, when you strike a blow to that internal image, they see it as just this. A total assault on their person
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