
Humanigen, Inc.
444 posts

Humanigen, Inc.
@humanigen
Humaneered® Monoclonal Antibodies to Neutralize Cytokine Storm Induced by SARS-CoV-2 (COVID-19), CAR-T, and GvHD. https://t.co/slsnc93hH3…

















The BA.4 & BA.5 Omicron subvariant-driven increase of new confirmed Covid cases in South Africa gives a good idea of what the endemic equilibrium will look like: a significant wave every 6 months with significant mortality & morbidity. 🧵

My main point was really how fast evolution has been proceeding. We see that SARS-CoV-2 variants have (1) displaced existing genetic diversity and (2) accumulated amino acid changes in the relevant domain much faster than seen in the fastest seasonal flu subtype H3N2. 2/13

The growth rate advantage of BA.4 & BA.5 over BA.2 is similar than that of BA.2 over BA.1 and of Delta over Alpha. But with caveat that BA.4 & BA.5 carry 2 mutations in the spike receptor binding domain that are predicted to confer some immune escape. twitter.com/jbloom_lab/sta…



