JN
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IMHO $TTD moat of true independence is underestimated. $AMZN competes with a lot of companies and can potentially compete with many more in the future. Any smart manager should think long and hard before handing over your business data to $AMZN voluntarily. You might save a few bucks in the short term, but eventually will time your own noose, which is obviously far more costly in the long run.
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@TheStalwart TCJA took effect Jan 2018; suspect that had something to do with the white line.
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@FutureJurvetson @centivax @DeanKamen How about Lime Disease from ticks? There’s an epidemic in the northeast US
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Master inventor Dean Kamen dropped by the office. He has 1,100 engineers at DEKA.
We focused on vaccines and better delivery methods 💉🦠
One of the risks with the standard intramuscular delivery mechanism occurs on rare occasion, where by bad luck, the delivery ends up in a vein instead of muscle tissue. Dean’s patch with MEMS micro needles could solve that and reduce the vaccine dosing 10x with intradermal delivery (because of the vastly higher concentration of dendritic cells in the skin). It is also pain free, and I posted a video demo on stage (below) with the CEO of Centivax speaking.
Centivax (where we recently led the Series A) has a new approach to universal vaccines that could end the risk of pandemics, including those yet to explode in humans (like H5N1 bird flu). With a universal vaccine, you have one shot that covers all the variants — the multitude of mutants that have made vaccines for certain diseases less effective and seasonally shifting (flu, coronaviruses, malaria, all herpes viruses, HIV, etc.).
When we look at the threats to human survival over the long arc of history, nothing comes close to pathogens. As a vector for many diseases, including malaria, the mosquito has killed half of every human that has ever lived. Pause for a moment on that. Just the mosquito-borne pathogens have killed 50 billion people.
Can we do better? Smallpox is a great case study. It was the target of the first vaccine, discovered in 1796. You can thank the smallpox vaccine for the eventual eradication of the disease. The virus only exists in freezers today. And before that? A billion humans have died of smallpox. There is even a smallpox god in the Hindu religion (Shitala Mata), a testament to the prayers and hopes for survival from this scourge... pre-vaccine.

Steve Jurvetson@FutureJurvetson
Dean Kamen demonstrates his low-cost self-administered vaccine delivery invention. No skills needed. No scary needle. Localized delivery to dendritic cells in the skin (to better promote an immune response). Universal vaccines (a single lifetime shot for all flu, HIV, malaria, or coronaviruses) from Centivax, Baker Lab at UW, and others will want better delivery methods for billions of people. At SynBioBeta today.
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@andrewcuomo I sincerely hope you have good political advisors and not ones who have advice that is no longer relevant. This is an important election.
Somehow M won the primary talking about $8 halal and being approachable. This resonated in an environment of low growth and high inflation.
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The Do-nothing assemblyman does not know how to get things done in Albany (or anywhere).
“Subject to negotiations with state lawmakers” means “I have no real plan so I’m going to get steamrolled during session.”
Emma G. Fitzsimmons@emmagf
Zohran Mamdani, pressed by @BrianLehrer on his plan to raise taxes on the wealthy and corporations, says the details are subject to negotiations with state lawmakers. But the goal is to make the city more affordable for everyone & the state as a whole benefits from NYC’s success.
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I am deeply grateful to my colleagues at DOGE and across the Federal Government for the honor of serving our country during this critical time. When I volunteered as a Special Government Employee, alongside two Valor colleagues, we set an end date of July 4, 2025 — exactly 130 days from our start, in accordance with the federal code governing SGE service limits.
This post is a response to claims that I abrogated my responsibilities to Valor and then “abandoned” our work at DOGE. These claims are false. I do not abandon commitments, either to the American people or Valor. The duration of my part-time service at DOGE, as well as that of my two Valor colleagues, was clearly communicated to the White House, DOGE, and our Valor community, with the end date firmly established. As White House spokesperson Mr. Fields noted, my role was always intended to sunset. I am grateful for the White House’s acknowledgment of the quality of our work and efforts to ensure a smooth transition to a new team, which I am confident will continue the work with dedication and excellence.
Using Valor’s standard operating playbook, we applied our lean expertise to address challenging situations at the SSA. Our process began with mapping complex systems, which unfortunately revealed serious issues that we worked collaboratively with exceptional public servants across government departments to resolve. From the beginning, our objective was to enhance the long-term financial stability of the SSA. Among our initiatives, we restored collection of billions of dollars of overpayments and worked to improve antiquated systems. While much work remains to be done, we made a positive and meaningful difference through these and other efforts.
I am strongly committed to supporting institutions and initiatives that provide Americans with financial security in retirement, including the SSA. Among our many clients are public and private pension systems that have supported their beneficiaries over many years. These systems are managed by exceptionally talented professionals dedicated to the retirement of millions of Americans. We are honored to be part of their communities and very grateful for their support. It is a privilege to work for them as we seek to deliver excellent returns and support their commitment to hard-working Americans, including the many teachers who rely on these systems for their retirement.
I am a product of Michigan public schools. While I disagree with the statements of the AFT, I also want to thank them. I appreciate their efforts to safeguard the pensions of teachers and other public servants across America. As a nation, we are united in service to our country, as well as in gratitude to the many who sacrifice and serve for the benefit of all of us, including our teachers. We know that by understanding each other, we are best positioned to achieve our common goals. Like the AFT, I am committed to fairness, democracy, economic opportunity, and high-quality education, healthcare, and public services for our students. Should the AFT ever want to have a conversation with me, I promise to approach the discussion with an open heart and mind. My request is that the AFT also do the same and promise to open their hearts and minds to me. Perhaps, if we listen to each other with compassion and our mutual love of America, we can understand each other better. I also believe that understanding each other is the first critical step to finding solutions to the important problems that face our country today.
I hope this is a moment where our compassion can be stronger than our anger.
Finally, I am deeply grateful for the support we received from teams across the government. Their dedication and patriotism will always inspire us. It was a great privilege to serve alongside them as we worked to strengthen our nation for all Americans. As I have under both Republican and Democratic administrations, serving my country when called upon will always be an honor.
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@P_Remarks I’ve debated this topic for years. Usually it doesn’t end well. Sometimes it does.
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Insurers are seeking hefty 2026 rate increases for Affordable Care Act marketplace plans, the coverage known as Obamacare.
If you are one of the millions who may face them, know that is but one consequence of the big and not so beautiful bill just passed, wsj.com/health/healthc…
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Good illustration of how much the Texas grid has changed in just 6 years.
yellow = solar; purple = batteries; dark green = wind; blue = gas; brown = coal; light green = nuke
via @grid_status

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The view that imagines AI wiping out jobs or causing some overnight shock to the system doesn’t contemplate that companies are a made up of a series of bottlenecks. When AI accelerates work in one area, you run into a bottleneck somewhere else.
As any individual workflow gets more efficient, the ultimate productivity gain is still constrained by some other part of the system. And usually it’s the case that that part of the system will not have inherently seen the same impact of AI efficiency, which means humans are still doing the work.
Take almost any process in an enterprise and you can see how this plays out. If AI Agents generate leads for the sales team, the bottleneck will be humans to have conversations with those customers. And if the leads are good, that will mean more sales hiring. If AI Agents generate more code, you will eventually be bottlenecked by the engineers that can review and incorporate that code into production.
You can quickly see how this scales to any process in an organization. Economists and others tend to totally miss how work actually happens in a company; it’s not a series of wholly independent tasks, but instead highly interdependent tasks that all link to each other across a system.
This is of course the natural rate limiter of AI efficiency gains, but also the reason why humans will still be doing so many jobs in the future.
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