John Mascola, MD

@Jasonmmast Congratulations Jason. Well deserved!

Very humbled by this award, which has gone to some of my favorite science writers over the years. And thankful to all the sources — parents, advocates, scientists — who gave parts of their very scarce time for these pieces

@EricTopol Depends on definition of significant. In context of total spike antibody response elicited by JN.1, would need to see more serological neutralization data to say this.

As predicted, KP.3 variant takeover in the US which creates a significant mismatch to the planned JN.1 new booster vaccine new CDC data #variant-proportions" target="_blank" rel="nofollow noopener">covid.cdc.gov/covid-data-tra…

@BLLPHD Congratulation to Carl for this well deserved recognition!

🚨🚨Carl June to receive 2024 Breakthrough Prize in Life Sciences #immunotherapy #tcell #CARTcell #tcellrx penntoday.upenn.edu/news/penn-medi…

@KizzyPhD @TIME So clear and thoughtful and I hope widely read!

Today, America’s COVID emergency is over. I penned lessons of the last 3 years in my first op-ed for @time; I focused on failures/lessons rather than successes, because we won’t be better the next time unless we highlight where we went wrong.

@McLellan_Lab @BarneyGrahamMD Such a great day for vaccine science. Congratulations!!

It's an incredible day for structure-based vaccine design, and I'm thrilled to see our prefusion RSV F antigen get approved as the first RSV vaccine. Still more work to do to reduce the RSV disease burden, but this will help! Congrats @BarneyGrahamMD! cnn.com/2023/05/03/hea…

@theNASciences @MSMEDU Congratulations Barney!

Congratulations Barney S. Graham of @MSMEDU, newly inducted #NASmember! #NAS160 #microbialbiology #immunology

@EJohnWherry @markmpainter Beautiful data and story - and clearly written for all to read. Congrats!

New data on breakthrough infection and the role of different components of adaptive immune memory generated by mRNA vaccines from @markmpainter biorxiv.org/content/10.110…

@VUMC_Vaccines @IG_lab @AShiakolas Awesome - Congratulations Andrea!

@Jasonmmast Thanks Jason, nerdy but useful. We'll all have to get used to this names. . .

And here ends the nerdiest short thread of my biotech career. Thank you for joining me on this wonderfully inane journey of discovery

Was surprised to see the name of Lillys new experimental Alzheimer’s antibody — remternetug — didn’t end in “mab,” as all antibody drugs do Learned that, apparently, the 3-decade era of “mab” ended last year, as scientists just ran out of new names(???) ncbi.nlm.nih.gov/pmc/articles/P…

@McLellan_Lab @ENirenberg @David_RMartinez Also, the VRC/NIH phase 1 study showed that alum adjuvanted and unadjuvanted DS-Cav1 were similarly immunogenic. I was surprised by this, but as Jason notes - preexisting immunity is key here.

@ENirenberg @David_RMartinez Apparently not. The protein trimers are quite immunogenic.

@McLellan_Lab @BarneyGrahamMD Thanks for sharing this amazing news. Proof of concept for structure based vaccine design!

Received an email from Rino Rappuoli this morning informing me, @BarneyGrahamMD and Peter Kwong of the positive phase III data for the RSV prefusion F vaccine results in older adults. It's been almost 10 years since we designed the first prefusion RSV F antigen, DS-Cav1. Amazing!

@camilahcoelho Congratulations. And thanks for the educational summary!

@McLellan_Lab So funny. Need a lift to stand with Barney - but hey, the beards look good!

Also, I'm standing on a stair and Barney is not

I wore a jacket today just to make @BarneyGrahamMD happy. You can tell how pleased he is :)

@GeoffreyHutch11 @BarneyGrahamMD Congratulations Barney - This is a fantastic and well deserved honor!

@rishirajgoel Beautiful data and summary!

For folks who are older or have other medical conditions, a 4th dose might have a lot of benefit. These folks tend to have lower antibody responses after 3 doses, and our data suggest that the relative benefit of boosting is greatest for individuals with lower pre-boost antibody

Our work on B cell memory to Omicron + other variants is now online @CellCellPress How does a 3rd shot of original mRNA vax work vs. variants? Does it increase the durability/quality of immune responses? What happens after a second boost? Key findings 👇 cell.com/cell/fulltext/…

@AShiakolas @IG_lab @croweje @TheBukreyevLab @McLellan_Lab Congratulations on this elegant work Andrea!

@BReinfeld @RMedzhitov @LabListon Yes. Cool science of fever! Harry Bernhiem was my professor also at Tufts. Worked in his lab studying endogenous pyrogen (IL1).

@RMedzhitov @LabListon Klugers Graduate student Harry Bernhiem was my undergrad immunology teacher. Crazy papers

Question for immunologists with an evolutionary bent. Why would fever have evolved? The magnitude is likely to be too mild for a direct anti-microbial effect, and as a signal mediator it is horribly dangerous compared to small molecule mediators

@EJohnWherry And we hope this holds for Omicron where there is some erosion of vaccine efficacy.

3 NEJM studies show durable protection from hospitalization over time despite waning protection from infection. Likely where we're heading - immunity making SARS-CoV-2 infection outcomes less severe. nejm.org/doi/full/10.10…; nejm.org/doi/full/10.10…; nejm.org/doi/full/10.10…

@EricTopol A treasure trove of tweets - amazing!

I get a lot of questions about "my team" who helps with my twitter posts. Let me make it clear. The "team" is me. >12 years, >40K posts, most since the pandemic began. Every one comes from me alone. N of 1.

@TheBcellArtist With Alpha, Delta, and even Beta, two mRNA immunizations produced reasonably high levels of virus inactivating antibodies. With Omicron, it takes three shots to get there.