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Just a fact.

It's safe to say I am the most anti-transgender member of Congress. 🇺🇸

@awfulannouncing This is gay

The Ronda Rousey-Gina Carano fight lasted about 15 seconds on Netflix.

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@bryan_johnson @foundmyfitness Which intern wrote this

Saying that sitting at a particular temperature for some time induces heat shock proteins is useless unless we link it to core body temp tracking in the individual. Heat stress and sauna research needs to move from single-endpoint population averages to personalized real-time tracking. Instead of targeting arbitrary times and temperatures based on studies, we looked at what core body temps actually trigger HSP release and expression. The lower edge sits somewhere between 101.3°F and 102.2°F (38.5 to 39°C), and it depends on the assay, exposure pattern, and cell type. Gibson 2016 found leukocyte Hsp72 mRNA needed Tcore ≥101.3°F (38.5°C) sustained for 27 min. Oehler 2001 found monocyte iHsp72 needs ~102.2°F (39°C) ex vivo. Hoekstra 2018 found whole-body HWI to peak 101.7°F (38.7°C) didn't raise monocyte iHsp72. Cell type also matters: monocytes induce HSP72 faster and at lower core temps than lymphocytes. Specifically on the paper used to make the HSP72 claim. 
The cited study (Iguchi 2012) actually lands the mean rectal temp at 101.3 ± 0.5°F (38.50 ± 0.27°C) after 30 min at 163°F (73°C), right at the lower edge of the HSP induction window. Individual increases ranged from 1.28°F to 2.16°F (0.71°C to 1.20°C): roughly half the subjects fell below 101.3°F (38.5°C), and essentially none reached 102.2°F (39°C). The HSP72 finding is also weaker than the "~50%" headline suggests. n=13 for the blood draws. Mean rise was 48.7% ± 53.9%, so the SD exceeds the mean: by a normal approximation, ~18% of subjects had no rise or a decrease. The absolute change was small (plasma went from 2.7 to 3.8 ng/mL). And critically, subjects (22 years old on average) were explicitly excluded if they regularly used saunas, so the cohort was heat-naive, where eHSP72 responses are largest and least representative of habitual users. The authors themselves note the rise was "much smaller than the exercise-induced increase" and flag that its clinical threshold is unclear. Moreover, 163°F (73°C) falls short of the best population longitudinal evidence for long-term mortality and chronic disease reduction with sauna. The Finnish KIHD mortality and dementia associations come from traditional Finnish sauna use at 176–212°F (80–100°C), 20+ min, 4 to 7 times/week (also summarized in your own 2021 review). While the 163°F (73°C) / 30 min dose might have elicited a partial eHSP72 response in the young healthy subjects of that individual study. It isn't within the range that maps onto the longitudinal longevity. We are moving on from small group descriptive statistics to personalized optimization with realtime tracking. Depending on your heat acclimation, vascular function, fitness, body composition, hydration, and ambient humidity, your target time and temperature to reach a core temperature of 101.3 to 102.2°F (38.5 to 39°C) might shift drastically.

Small correction here. You don’t need to reach a core temperature of 102.3°F to activate HSP expression. And you definitely don’t need to sit in a 200°F sauna for 30 minutes. The research shows HSP expression can increase by ~50% after 30 minutes at 163°F, with core body temperature rising to only about 101°F. Sauna benefits (even those related to HSPs) don’t require extreme heat or pushing core temperature that high.

Last week, two grizzly bear attacks claimed the life of a hiker in Glacier National Park and seriously injured two others in Yellowstone National Park. These tragedies are a sobering reminder that grizzly bear populations have recovered well beyond sustainable levels, and it is past time for the federal government to delist them and give states the management tools they need to protect both people and wildlife. Delist the grizzly.

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@colomo214 Can we switch Lithuania for Poland

@FirstSquawk @GeromanAT Looking back

URSULA VON DER LEYEN: LOOKING BACK, I BELIEVE IT WAS A STRATEGIC MISSTEP FOR GERMANY TO ABANDON NUCLEAR ENERGY — IF WE ARE SERIOUS ABOUT CLIMATE, BOTH GAS AND COAL ARE FAR MORE HARMFUL THAN NUCLEAR.

Canadas tough A girl asks you for a cigarette and you gotta pull out the pack of limp dicks

Friendly reminder to check for ticks

Water cooler talk of the day: “Did you hear that Clav OD’ed last night?”

@WhiteHouse What the fuck does that even mean

TRUST IN TRUMP 🔥

@DMichaelTripi Someone tell Hegseth separation of church and state goes both ways

Tax tip of the day: if you file domestic abuse charges you can withdraw your 401k penalty free

Me after Illini win tonight

Are you scared yet?

Showing the Home Depot guy how long the PVC should be