Nicky Edmonds

The Fitness Tracker For your 𝐆𝐞𝐧𝐞𝐬. 🧬 We’re all familiar with the numerous health and fitness trackers on the market: 𝐎𝐮𝐫𝐚, 𝐀𝐩𝐩𝐥𝐞, 𝐖𝐡𝐨𝐨𝐩, 𝐆𝐚𝐫𝐦𝐢𝐧 and 𝐅𝐢𝐭𝐛𝐢𝐭 to name but a few. These are all fantastic bits of wearable health technology that highlight and provide excellent, real-time monitoring of your output across a whole variety of health metrics. Perhaps you use them to understand how well you sleep, the number of steps you take, your heart rate variable, or how stressed the kids or work make you on a daily basis! 𝐁𝐮𝐭 𝐭𝐡𝐢𝐬 𝐢𝐬 𝐰𝐡𝐞𝐫𝐞 𝐭𝐡𝐞𝐲 𝐟𝐚𝐥𝐥 𝐬𝐡𝐨𝐫𝐭…… Wearables Track Transient Symptoms. Muhdo Measures the Biological Root Cause. The key distinction here is that health and fitness trackers provide real-time outputs, while Muhdo's DNA and Epigenetic tracking provide the biological inputs that determine those outputs. Health and fitness trackers help you to understand what you did (activity) or how your body responded in the moment. Muhdo Health's DNA and Epigenetic testing tells you who you are biologically, why you respond that way, and how to fundamentally change your biological health for the better. 𝐖𝐡𝐲 𝐆𝐨 𝐃𝐞𝐞𝐩𝐞𝐫 𝐓𝐡𝐚𝐧 𝐓𝐡𝐞 𝐒𝐮𝐫𝐟𝐚𝐜𝐞? ·   𝐈𝐬 𝐲𝐨𝐮𝐫 𝐬𝐮𝐩𝐩𝐥𝐞𝐦𝐞𝐧𝐭 𝐬𝐭𝐚𝐜𝐤 𝐚𝐜𝐭𝐮𝐚𝐥𝐥𝐲 𝐰𝐨𝐫𝐤𝐢𝐧𝐠? 𝐌𝐞𝐚𝐬𝐮𝐫𝐞 𝐢𝐭. ·   𝐈𝐬 𝐬𝐭𝐫𝐞𝐬𝐬 𝐚𝐠𝐞𝐢𝐧𝐠 𝐲𝐨𝐮. 𝐖𝐞 𝐬𝐡𝐨𝐰 𝐲𝐨𝐮 𝐡𝐨𝐰 𝐦𝐮𝐜𝐡. ·   𝐒𝐞𝐞 𝐭𝐡𝐞 𝐢𝐦𝐩𝐚𝐜𝐭 𝐨𝐟 𝐥𝐚𝐬𝐭 𝐧𝐢𝐠𝐡𝐭'𝐬 𝐬𝐥𝐞𝐞𝐩 𝐨𝐧 𝐲𝐨𝐮𝐫 𝐜𝐞𝐥𝐥𝐬. Better health always starts beneath the surface. And the fastest way to see if your anti-ageing routine is working. 𝘈𝘴 𝘦𝘷𝘦𝘳𝘺 𝘭𝘪𝘧𝘦 𝘤𝘩𝘰𝘪𝘤𝘦 𝘺𝘰𝘶 𝘮𝘢𝘬𝘦 𝘦𝘪𝘵𝘩𝘦𝘳 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘴 𝘰𝘳 𝘴𝘭𝘰𝘸𝘴 𝘺𝘰𝘶𝘳 𝘪𝘯𝘵𝘦𝘳𝘯𝘢𝘭 𝘤𝘭𝘰𝘤𝘬. muhdohub.com

𝐓𝐡𝐞 𝐍𝐞𝐰 𝐄𝐫𝐚 𝐨𝐟 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐂𝐥𝐨𝐜𝐤𝐬🧬 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐀𝐠𝐞𝐢𝐧𝐠, 𝐟𝐫𝐨𝐦 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐢𝐭𝐲 𝐭𝐨 𝐂𝐥𝐚𝐫𝐢𝐭𝐲 Albert Einstein famously once said… "𝘐𝘧 𝘺𝘰𝘶 𝘤𝘢𝘯'𝘵 𝘦𝘹𝘱𝘭𝘢𝘪𝘯 𝘪𝘵 𝘴𝘪𝘮𝘱𝘭𝘺, 𝘺𝘰𝘶 𝘥𝘰𝘯'𝘵 𝘶𝘯𝘥𝘦𝘳𝘴𝘵𝘢𝘯𝘥 𝘪𝘵 𝘸𝘦𝘭𝘭 𝘦𝘯𝘰𝘶𝘨𝘩." I’m pleased to say that @Muhdohealth have now had our DNA methylation clock 🧬 validated, published and peer reviewed.📚🔬 👉 lnkd.in/eJFw8FCr 👈 This is a huge stride forward for the team and UK 🇬🇧Science 🔬in general. We were the first DNA and Epigenetics 🧬company globally to launch a biological age and epigenetics app back in 2019 just before the pandemic. And have now validated in many ways our unique science 🔬with the help of Henry Chung from the University of Essex 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐦𝐞𝐞𝐭𝐬 𝐬𝐢𝐦𝐩𝐥𝐢𝐜𝐢𝐭𝐲. 𝐀𝐛𝐬𝐭𝐫𝐚𝐜𝐭 𝐁𝐚𝐜𝐤𝐠𝐫𝐨𝐮𝐧𝐝/𝐎𝐛𝐣𝐞𝐜𝐭𝐢𝐯𝐞𝐬: DNA methylation profiles have emerged as robust biomarkers of ageing, leading to the development of “epigenetic clocks” that estimate biological age. Most established clocks (e.g., Horvath’s 353-CpG pan-tissue clock and Hannum’s 71-CpG blood clock) require dozens to hundreds of CpG sites. This study presents a novel saliva-specific epigenetic clock built on 10 sites identified from Illumina MethylationEPIC (850 k) array data. 𝐌𝐞𝐭𝐡𝐨𝐝𝐬: Saliva DNA methylation was analysed from 3408 individuals (age range 15–89 years, 68% male, 32% female, no diagnosed disease) from the Muhdo Health Ltd. dataset (2022–2024), and 10 CpG sites were selected where methylation levels showed the strongest positive correlations with chronological age (Pearson r = 0.48–0.66, p< 1 × 10−20). These CpGs map to genes involved in developmental and metabolic pathways (including ELOVL2, CHGA, OTUD7A, PRLHR, ZYG11A, and GPR158). A linear combination of the 10 methylation sites was used to calculate a “DNA methylation age”. 𝐑𝐞𝐬𝐮𝐥𝐭𝐬: The 10-CpG clock’s predictions were highly correlated with chronological age (r = 0.80, R2 = 0.64), with a mean absolute error of ~5.5 years. Its performance, while slightly less precise than Horvath’s or Hannum’s multi-CpG clocks, is notable given the minimal marker set. It was observed that all 10 clock CpGs undergo age-related hypermethylation. The biological significance of these loci is discussed, along with the potential health and forensic applications of a saliva-based epigenetic age predictor. 𝐂𝐨𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧𝐬: This study demonstrates that a saliva-specific epigenetic clock using only 10 CpG sites can capture a substantial portion of age-related DNA methylation changes, providing a cost-effective tool for age estimation.

𝐕𝐢𝐭𝐚𝐟𝐨𝐨𝐝𝐬 𝐄𝐮𝐫𝐨𝐩𝐞 𝐁𝐚𝐫𝐜𝐞𝐥𝐨𝐧𝐚 2025 Precision Nutrition and Preventive Medicine Leveraging AI to Boost Healthspan Thank you to @Vitafoods_ Europe for inviting me again to the conference, but this year to Barcelona to be part of yesterday’s panel discussion surrounding "Precision Nutrition and Preventive Medicine" The panel was hosted in collaboration with the European Society of PreventiveMedicine and moderated by Dr Richard Siow Director of Ageing Research at King's College London (ARK-AI) Richard and myself had the pleasure to be joined by 3 fantastic gentleman. The “Godfather of Epigenetic Clocks” and the pioneer of the Horvath Clock back in 2013 Professor Steve Horvath from Altos Labs, Gerard Vinyes Parés from Nestlé Health Science and Josep M del Bas from the Universitat Rovira i Virgili. We had a chat about AI, nutrition, health data, genomics, epigenomics, 🧬metabolomics plus a couple more omics that I can’t remember ha-ha. Thank you to all of the team at Vitafoods, as well as Richard, Steve, Gerard and Josep. And of course @nicky_edmonds from the @Muhdohub team 🧬 I look forward to seeing you all again next year. @Muhdohealth @MuhdoFightHub

Barcelona bound for @Vitafoods_ Ready to dive in & explore new scientifically proven, next generation ingredients & unique delivery systems, to support @Muhdohealth product development…some real game-changers coming! Looking forward to browsing booths with @JamesGene258811

A Global Breakthrough in Health — Powered by Muhdohub & Oxford University We’re proud to announce a major partnership between Muhdohub and @UniofOxford — working together to revolutionize healthcare with cutting-edge technology. We're introducing the world’s first INSTANT infection detection solution, integrated directly into nappies. This allows for early identification of infections through urine, offering: ✅ Instant results — no invasive blood tests ✅ Home, hospital, and on-the-go monitoring ✅ Faster treatment, fewer delays, and life-saving interventions This is more than innovation — this is one of the biggest moments in #DeSci so far! The commercial opportunity from this breakthrough is projected to generate huge global revenue, directly fueling the growth and value of our MuhdoHub ecosystem. Healthier lives. Stronger communities. A thriving future for science and commerce. 🎥 Watch the full interview with the creators and discover how Muhdo Hub is trying to shape the future of health. $DNA #GlobalHealth #MuhdoHub #OxfordUniversity #DeSci