Ryan Ross

@bryan_johnson If enough people live forever, we will never need new people. But, making new people often happens when you go to bed later. So this will probably even out 🤣

How to avoid tons of life problems: go to bed on time.

@AWSSupport Case ID: 177939150400664 I would love to get this working.

@ryanrossnow I'm sorry to hear about this experience Ryan. I've passed along your feedback internally for review. ^GJ

AWS has got to be the worst user interface i've ever experienced. @awscloud please do better and make it easier for me to upgrade my account.

@lourencoczernin @ArthurMacwaters Its no that their state is 'winning', but that they've 'won' things in the past. They fail a lot, but they keep going. They will continue to fail a lot, to test the edges of what is possible.

@ArthurMacwaters I'm confused, can we honestly say his companies "won"? I admire the grandiosity of his vision and the leadership ability i know these are the kind of people who shape history, but the way I see it, it can still go both ways

I called my engineer friend at SpaceX the other day. 1am Pacific. 3am in Starbase. He was still in the office and not going home any time soon. And he was happy. Energized. Because he's directly influencing the course of a multi-planetary future for humanity. On a fundamental level, this is why Elon companies win. Young, high-competence people are given exceptional individual agency and semi-impossible problems. And they know that their contribution is essential. Any company that does this is much more likely to succeed. Elon does this without fail. Inspires me a lot.

@Jacobsklug OS

I built a Claude Cowork OS that replaces OpenClaw and runs on autopilot. Manages my business & personal life tasks. I created the whole playbook so you can re-build it tonight. What's inside: • The exact foundation prompt • 3 level orchestration map • Memory template for global context • Routing table for file management • Starter workstations (finance, content, community, habits) • Project file structure • Single prompt that builds the entire folder tree Follow + Comment 'OS' and follow. I'll DM it to you.

@noahkagan Happy to contribute. We are in the health insurance space.

I'm launching a marketplace for Vibe-Coded apps + AI Skills 👉 think AppSumo for people building with Claude/Codex in a weekend. Looking for early beta partners, DM me or leave comment. Will get exposure to 1 million peeps.

@patrick_oshag Gotta ask- what kind of Mic stand is that??

Krishna Rao is the CFO of Anthropic, and this is his first podcast appearance. He joined the company two years ago when run-rate revenue was about $250M. Today it is $30B. He has helped raise ~$75B and is responsible for the procurement and allocation of compute. I feel lucky we get to hear what it is like to sit inside a company this consequential at a moment this pivotal. We discuss: - The cone of uncertainty - How he allocates compute across Trainium, TPUs, and GPUs - What investors misunderstand about model companies - Why the returns to frontier intelligence keep rising - Platform vs application and where Anthropic builds its own products - How Anthropic uses Claude internally I have asked my closing question about the kindest thing more than 500 times. Krishna's answer is one I have never heard before. Enjoy! Timestamps: 0:00 Intro 2:38 The Compute Canvas 6:51 The "Cone of Uncertainty" 11:58 Why the Returns to Frontier Intelligence Are So High 16:45 Recursive Self-Improvement 20:20 Scaling Laws 23:30 Sourcing $100 Billion in Compute 28:05 Platform vs. Application Strategy 32:52 Pricing Dynamics 38:48 How Anthropic’s Finance Team Uses Claude 43:24 Raising Capital & Overcoming Investor Skepticism 52:32 Public Perception, Risks, and Government Regulation 57:25 Mythos Release 1:12:33 What Could Derail the AI Revolution? 1:13:47 Biotech and Healthcare 1:15:31 The Kindest Thing

@bryan_johnson Can we have a “people with young kids” version of this.

This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most powerful drug. 1. Be in your bed for 8 hours 2. Same bedtime every night, any time before midnight 3. Don’t eat right before bed 4. Calm foods for dinner 5. No screens 1 hour before bed 6. Avoid added sugar (be aware it’s in everything) 7. Avoid all things in an American convenience store 8. Avoid fried foods 9. Shoes off at the door 10. Eat whole foods, particularly veggies fruits nuts legumes berries 11. Walk a little after meals or air squats 12. Get your heart rate high routinely 13. Lift heavy things 14. Stretch daily 15. Water pik, floss, brush, tongue scrape, morning and night 16. Make an effort to drink water 17. Get sunlight when you wake up (UV is low) 18. Protect skin in midday sun 19. Stand up straight 20. See at least one friend once a week 21. Avoid plastic where you can (in all things) 22. Circulate air in rooms 23. When stressed, breathe, learn to calm your body 24. Go to the dentist 25. Avoid sitting for long times 26. Protect your hearing, the world is too loud 27. Alcohol is bad for you 28. Finish coffee before noon 29. Avoid bright lights after sunset 30. If obese, look into a GLP 31. Sleep in a cold room 32. Texting while driving is dangerous 33. Turn off all notifications 34. Limit social media use 35. Don’t smoke anything 36. If you struggle to sleep, read a physical book before bed 37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music 38. The body is a clock and loves routine. Have a daily morning and evening schedule. 39. Avoid long distance travel where you can 40. Baby steps first: incorporate new things slowly 41. Do less… most things don’t work. Bonus points if you get your blood checked. Start here, it will change your life.

Claude watching me book a flight, hotel and rental car on Priceline

@RitholtzWealth @mattcerminaro probably because the fed printed a boatload of cash...right? and where does that cash go eventually...big companies ,right?

$100 Billion Companies "At the Covid-19 low, only 42 companies in the S&P 500 traded at a valuation above $100 billion. That number has nearly tripled since 3/23/2020. Incredible." buff.ly/zWu1skK by @mattcerminaro

@JonahLupton @DavidSacks @theallinpod @Jason @chamath @friedberg Even @Jason

@DavidSacks @theallinpod @Jason @chamath @friedberg Congrats to the whole group.

💪

@businessbarista Ai-native

I want to start an AI community for executives. This will be a space for people to share killer use cases, agentic workflows/agents, post-AI org structure, AI governance, AI training/enablement, change management, and more. Comment “AI-native” if you want to join.

It’s our favorite time of year! It’s time for the: Quarterly Quarter Cow Contest One person who retweets and follows CrowdHealth will be eligible for a quarter cow delivered directly to your home by the famous @jakesteaks1 These are grass fed beauties from womb to tomb. Winner will be announced on 5/11. (US only. You do not need to be a CrowdHealth member). Exit the system and join CrowdHealth. $200/month max for singles <55 ($135 in May) $660/month max for family of 4 ($465 in May) joincrowdhealth.com

Mapped: The Happiest States in America 😊 visualcapitalist.com/happiest-state…

@RobertMSterling @SMB_Attorney @KHendersonCo @smblawgroup The Visalia nut task force loves these guys.

@KHendersonCo @smblawgroup Sir

4 years ago today, three BigLaw-trained M&A lawyers launched a firm to serve the deals BigLaw refused to touch. Just a couple short years later, @smblawgroup had dethroned every white shoe firm in America to become the #1 M&A law firm in Texas by deal count. And man, what a wild ride it has been! 4.5 years ago, @SMB_Attorney and I were on the phone chatting about how much his DM's had blown up (while still anon) with active deals in need of a good M&A lawyer. Finding a lawyer wasn't hard. But a good one? Those ones were $2,000+ an hour, populated expensive downtown offices, and staffed transactions with a couple basketball teams of lawyers. And candidly, those guys just weren't interested in $3.5 million main street deals. Conversely, while Eric and I were those BigLaw guys, we wanted nothing more than to do main street deals. So throwing caution to the wind, we hatched a plan to launch a main street focused M&A boutique. Entrepreneurs signing a personal guaranty for the most important transaction of their lives deserved the best. When we met @Sam_Rosati a few months later, I think his first reaction was something along the lines of "I've been waiting years for someone to build a firm like this." And just like that...the idea was instantly validated with one of the most trustworthy voices in ETA. What we didn't know at the time was how how much this would change our lives. Since that date 4 years ago we have: ▪️Added appx. 20 team members ▪️Closed over 375 deals with over $1.75B in enterprise value! ▪️Been published and recognized in Forbes, Bloomberg, Yahoo! Finance, and more ▪️Won various awards, including for law firm innovation and @SMB_Attorney as managing partner of the year in Florida ▪️Dethroned every white shoe law firm in America to become the #1 M&A law firm in Texas by deal count I'm incredibly grateful to have partners like @SMB_Attorney and @Sam_Rosati, along with an incredible team of lawyers and staff that have bought into the vision to become the #1 lower-middle market law firm in America. We're well on our way and I can't wait to see what the next 4 years bring! 🚀🚀🔥🔥

@SMB_Attorney Ryanair does it every day. Probably cheaper. Ryanair should buy the it !

Hear me out: We’re putting hundreds of people into a multi-million-dollar machine, navigating it 30,000 feet in the air at 500+ mph, powered by thousands of gallons of fuel, maintained by experts, and coordinated globally… …and we’re surprised it can’t be done for low cost?

@toddsaunders When is it ?

I want to get the most AI pilled folks in NJ for a meetup in Westfield. I have no idea how to source or find these people so please X do your thing!

@wallstreetpapii @SMB_Attorney Avoid the audiobook.

@SMB_Attorney phenomenal

Sam Altman’s home vs Elon’s… I think this tells you everything you need to know.

@sweatystartup Do you get angry ?

The best longevity drug in history is totally free. It's called autophagy. Several things happen when you do a 3 day fast: - your body cannibalizes bad cells / pre-cancer cells / heart plaque - gene expression changes at the 72 hour mark and body goes into hyper recovery mode - 5x stem cell boost upon re-feeding I do a 72 hour fast 4x a year. Valter Longo is a world renowned longevity doctor and is the master on this stuff.

@NYCMayor Who can shop there ? Any limits on how much you can purchase ? Will prices be listed ?

Last year, I told New Yorkers: we would open city-owned grocery stores to take on the affordability crisis. Today, we're delivering five stores — one in each borough — with the first opening next year. We're building a city where people can afford the basics, leave survival mode behind, and pursue their dreams. Here's to healthy families, thriving communities, and promises kept.