Biophysical Journal

In the New and Notable "Rethinking contractility in active cytoskeletal matter," Tamara C. Bidone highlights the paper "Nonuniform filament turnover, contractility, and bundle formation in disordered actomyosin networks." buff.ly/fo7liVM

#OPENACCESS: Biomolecular condensates behave less like water, more like slime in a lava lamp: stretchy, flowing, yet structured. Zhang et al. use “computational rheometry” to probe their squish & stretch, revealing how cells tune mechanics inside. buff.ly/B4OHcYv

#OPENACCESS: Consecutive prolines and polyproline II helices stabilize features in PRD domain, making the p53 structurally dynamic—a requirement for the tumor suppression function of p53. This dynamic is compromised in disease variants. buff.ly/P1aenha

Special issue call for papers: Physical Properties of Cells: From Measurement to Medicine, A Tribute to Jochen Guck. buff.ly/CIiCPrw

In the New and Notable "When the nucleus disconnects, cells lose their way," Tanmay P. Lele highlights the paper "Disruption of nuclear-cytoskeletal connection impairs epithelial cell mechanosensing and collective migration." buff.ly/FskUmHa

Tam and colleagues use mathematical modelling to show how different modes of actin turnover influence contractility in disordered actomyosin networks, revealing how nonmuscle cells tune force through varying actin turnover pathways. buff.ly/fo7liVM

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/dMaXw2y

#OPENACCESS: Continuum and discrete modeling of binding-site distribution-mediated reactions on lipid surfaces. Han Cao, Anirban Sen Gupta, and Karin Leiderman. buff.ly/sXaclMD

#OPENACCESS: Mechanisms of thrombin inhibition by protein S and the TFPIα-fVshort-protein S complex. Alexander G. Ginsberg, Josefin Ahnström, James T.B. Crawley, Karin Leiderman, Dougald M. Monroe, Keith B. Neeves, Suzanne F. Sindi, and Aaron L. Fogelson. buff.ly/776MSnZ

#OPENACCESS: A tunable, ultrasensitive threshold in enzymatic activity governs the DNA methylation landscape. Kwadwo A. Bonsu, Nandor Laszik, Annie Trinh, Timothy L. Downing, and Elizabeth L. Read. buff.ly/M6QOAWL

#OPENACCESS: Quantifying the effect of magnesium ions on nucleosome stability in chromatin fibers. Luuk J.C. Daris, Lieke A. Lamers, Kes van Blitterswijk, Camila Delgado Zuvanic, and Jorine M. Eeftens. buff.ly/61RbxbN

Special issue call for papers: Genome Organization: Integrating Mathematics, Physics, and Computation for Advances in Biology and Medicine.buff.ly/4vb6Yza

#OPENACCESS: Chlorpromazine inhibits EAG1 channels by altering the interdomain coupling. Kyle Kihn, Ze-Jun Wang, Xi Chen, Mahdi Ghorbani, Purushottam B. Tiwari, Jeffery B. Klauda, and Tinatin I. Brelidze. buff.ly/9o2ChvB

#OPENACCESS: Spatial triple-correlation spectroscopy reveals heterotrimer dynamics in live cells. Julissa Sanchez-Velasquez, Tao Sun, Xiaomeng Zhang, and Elizabeth Hinde. buff.ly/PD2BWTU

#OPENACCESS: Protonation-dependent substrate release in a bacterial homolog of vesicular glutamate. Charles Plate, Natalia Dmitrieva, Samira Gholami, Mercedes Alfonso-Prieto, Sanket A. Deshmukh, Davide Mandelli, Paolo Carloni, and Christoph Fahlke. buff.ly/kYylVyX

#OPENACCESS: HaloTag-based approach to quantify subcellular localization of TRPV3 channels. Alexander Holloway, Joshua Chiang, Afroza Khan, Eric N. Senning, and Andrés Jara-Oseguera.

#OPENACCESS: Biomimetic emulsions behave like a crowd at a party—some guests cling, others drift. Quentin Guigue et al. (2026) show how these adhesion vibes tune the flow, turning mixtures from chill to jam-packed dance floors. buff.ly/faEVWcl

#OPENACCESS: Distributional invariance and proportional scaling in axonal conduction. Laurie D. Cohen and Shimon Marom. buff.ly/13BEYGL

#OPENACCESS: The authors develop an integrated approach combining NMR spin relaxation measurements with MD simulations to quantify backbone rigidity in short, disordered peptides, the study helped correlate the sequence effects on the linker properties. buff.ly/EptkIim

Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/34cLMw6