Xiaoding Jiang

Excited to share new findings led by postdoctoral fellow Xiaoding Jiang. We developed an electrophile-drug conjugate (EDC) that site-specifically and proteome-wide selectively activates PFKL coupled to delivery of a cytotoxic payload in vivo biorxiv.org/content/10.110…

[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/full/10.10…

Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group! pubs.acs.org/doi/10.1021/ac… @CovalentMod @UTChemistry @UTAustin

Innate immune memory after brain injury drives inflammatory cardiac dysfunction: Cell 🧐cell.com/cell/fulltext/…

The value of ‘wasting time’ on deep thinking is often overlooked in a scientific ecosystem increasingly tainted by Wall Street’s productivity mindset. nature.com/articles/d4158…

Excited to share our latest @JACS_Au paper on the late-stage editing of the Ginkgo biloba natural product!🍀 Huge thanks to our talented postdocs @XiaodingJ & Jon Wong, and PhD student Xu He for their incredible efforts! 👩‍🔬👨‍🔬Link: pubs.acs.org/doi/epdf/10.10…

How to Write Clearly #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science #job #Postdoc

.@cuhkpharmacy has designed a novel class of small molecules named O-GlcNAcylation Targeting Chimeras (OGTACs), offering a pioneering method for precisely manipulating #protein function in living #cells, with the potential to revolutionise the #treatment of a range of #diseases. bit.ly/3KlDG0j 📖@J_A_C_S: bit.ly/3yNEHM2

Online now! Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation dlvr.it/T7BmG8

“Science is like art, it is creative. We are not creative if you are only talking to some people. We need to talk to everybody.” Watch Nobel Prize laureate @MayBrittMoser discuss how diversity impacts creativity at our #NobelPrizeDialogue: youtube.com/live/99VjiKDv-…

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

The anticancer efficacy of CAR T cells is enhanced by overexpression of FOXO1. nature.com/articles/s4158… nature.com/articles/s4158… #NBThighlight

Delighted to share our "OGTAC" story as an open-access article on @J_A_C_S !😉 #glycotime Link: pubs.acs.org/doi/10.1021/ja…

Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules | Journal of the American Chemical Society @Billy_WL_NG @CUHKMedicine #Protein #GlcNAcylation #Bifunctional #SmallMolecules pubs.acs.org/doi/10.1021/ja…

Phenomenal new reactions, new oxaziridine reagents, and their application in the discovery of functional tryptophan interactions. 👍👍👏👏 @christhechang @Toste_Group nature.com/articles/s4158…

What is a scientific paper? Why do we write it? How? This 3-page handout, created by George Whitesides on 4 October 1989, offers practical answers. Strongly recommended for researchers of all ages. Whitesides' Group: Writing a Paper intra.ece.ucr.edu/~rlake/Whitesi…

nature.com/articles/s4158… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/@ForliLab & @bmsnews

As we step into 2024, let’s focus on a key academic resolution: enhancing our students’ writing skills. Writing is first and foremost about organizing your thoughts and ideas, not just facing a blank page and hoping for inspiration. A thread🧵 #academicwriting #Resolutions

Congrats to my students Myungsun Shin, Tim Ware, and Miaomiao Chen on their paper in PNAS describing LKB1-AMPK regulation by endocannabinoid biosynthetic enzymes. Great collaboration with the Lichtman, Leitinger, and Harris labs. pnas.org/doi/10.1073/pn…

There's currently no drug for RSV infection😷🦠 Thrilled to share our discovery of a new anti-RSV drug prototype @CUHKMedicine, utilizing a readily available sugar as the key starting material!💊 Reach out for collaborations & licensing!📩 pubs.acs.org/doi/10.1021/ac…