Medscape

Patients newly diagnosed with inflammatory bowel disease (IBD) had higher proportions of anxiety and depressive symptoms than the general population and showed sex differences. Substantial fatigue and lower self‑efficacy were linked to increased odds of anxiety and depressive symptoms. mdsc.pe/4siiZpN

An analysis of 6 years of Taco Bell drive-through transaction data from 120 locations across the US found that implementing taxes on sugary drinks was not associated with changes in calories from beverages per transaction. mdsc.pe/4s97BfB

The expiration of ACA subsidy enhancements is already taking a toll on primary care. With subsidy credits ending, physicians are seeing drops in patient volume and revenue as more patients lose affordable coverage or delay care. The ripple effect: fewer visits, more untreated conditions, and growing strain on already stretched primary care practices. mdsc.pe/4mbth9G

Memory loss and aging go hand-in-hand for most of us, but scientists are getting closer to understanding why. A new study, conducted by researchers at the Arc Institute in Palo Alto, California, and published in Nature, found that a prime suspect may be living in our gut. mdsc.pe/48bzPPK

The concept of “prediabetes” may be on its way out. Some experts are proposing a shift to staging type 2 diabetes instead, arguing that the current label can be misleading and may delay more proactive treatment. A stage-based approach could better reflect disease progression and encourage earlier intervention. mdsc.pe/3O4aXmi

This curriculum will empower you with the latest evidence, case based guidance, and practical resources—helping clinicians move beyond trial and error to deliver better GERD care. ▶️ mdsc.pe/4sLttyL

A new review highlights the rapidly expanding role of therapies that stimulate or modulate vagus nerve activity, with potential applications across a wide range of conditions. These include inflammatory diseases, neurologic disorders, and mental health conditions, reflecting growing interest in “bioelectronic medicine.” As devices become more advanced and less invasive, the vagus nerve is emerging as a key target for treating disease by influencing the body’s own neural and immune pathways. mdsc.pe/4tjrCkB

Several allergenic plant foods not required to carry allergen labeling in Europe — particularly certain seeds and legumes — often triggered severe allergic reactions, including anaphylaxis. mdsc.pe/4m6mtdn

Doctors are told to raise safety concerns, but some face isolation, disciplinary action, and lasting career consequences when they do. mdsc.pe/4cnsGyc

Early results of an investigational HER3-targeting antibody-drug conjugate (ADC) showed anti-tumor activity across several subgroups of pretreated patients with non-small cell lung cancer (NSCLC). More on the study: mdsc.pe/3NDHakk

Engaging in mentally active behaviors, such as office work and knitting, while sedentary was associated with significantly lower dementia risk than mentally passive behavior, such as watching television, new research showed. mdsc.pe/4dZ15om

The U.S. Food and Drug Administration is moving toward allowing compounding pharmacies ⁠to produce more than a dozen injectable peptides that were banned because of ⁠potentially significant safety risks, the New York Times reported on Tuesday, ⁠citing a senior administration ‌official. The FDA in 2023 removed 14 peptides from a list of products that ‌it allows compounding pharmacies to produce. The compounded peptides ​were commonly ‌used in wellness, integrative ‌medicine, and sports medicine. The agency had said the move was based on ⁠significant safety risks, including risks related ‌to immunogenicity, toxicity ⁠, and impurity of the ​peptides. Tap the link to read more: mdsc.pe/41bfCFW

The ability to avoid routine needle carrying skyrocketed the value-based price (VBP) of nasal epinephrine to more than 1200% above baseline, according to new modeling data presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology. More on the data: mdsc.pe/47Bkyrj

Managing DKA in adults starts with recognizing that the risks have changed. Experts share why the "frail and elderly" are now a primary concern for recurrent episodes and how to tighten insulin consistency. Watch the full discussion for more clinical pearls ➡️ x.com/i/broadcasts/1… #CME

The first-ever clinical trial of an adeno-associated virus (AAV) gene therapy for type 1 diabetes (T1D) is set to begin this year. The PROGRESS study will enroll adults with T1D to receive a one-time intramuscular injection of KRIYA-839 and follow them for 1 year for both safety and efficacy endpoints. More on the trial: mdsc.pe/4c10hNj

Oral GLP-1 receptor agonists are generating a great deal of excitement as a potential inflection point in diabetes and obesity care. Amid the enthusiasm, however, a quieter and clinically important issue is emerging for primary care clinicians: how oral GLP-1s interact with the realities of polypharmacy and medication timing in everyday practice. Unlike injectable GLP-1s, oral formulations depend on precise dosing conditions and alter gastric physiology, raising questions about drug-drug interactions, inconsistent exposure, and silent erosion of therapeutic benefit in real-world use. mdsc.pe/4s9ioq8

Real World Insights at ACC: An AMA with Dr. Mandrola x.com/i/broadcasts/1…

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Arthritis affects 1 in 4 adults, yet 73% of healthcare clinicians underestimate the true scale of the disease and its impact on daily activity. Even more surprising: nearly 60% of clinicians don't know the gold-standard physical activity guidelines for arthritis, and 61% underestimate how much movement actually reduces pain. Our research is now featured on the CDC website: mdsc.pe/4m7IWGR

Starting in 1 HOUR ➡️ youtube.com/watch?v=GJpjfy… Trial data is evolving. Are you staying current? Join @drjohnm LIVE as he answers your toughest questions from the floor of #ACC26. #ACC #Cardiology