Wataru Fujii

Experts reach consensus to rename polycystic ovary syndrome (PCOS), better reflecting the condition’s full health impacts. Find out more 👉 spkl.io/6011ACDWW @ESEndocrinology #ECE2026

Reverse transcriptase inhibitors enable the generation of fertile spermatids from fetal mouse testes in vitro: Communications Biology, Published online: 27 January 2026; doi:10.1038/s42003-026-09613-yReverse transcriptase inhibitors combined with hypoxia… dlvr.it/TRHmB0

The experimental small-molecule inhibitor ARN-75039 offers strong protection against #LassaVirus infection in guinea pigs at varying dosing schedules and when given as long as 7 days postexposure, according to new work in @ScienceTM. scim.ag/4mAQ3YN

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

Generation of functionally competent testicular somatic cells from pluripotent stem cells | Science Advances science.org/doi/10.1126/sc…

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells | Science science.org/doi/10.1126/sc…

Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design "the extension of biosensors by customizing signal processing and output modules to expedite the transition of synthetic biosensors from laboratory settings to field applications" advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Mammalian genome writing: Unlocking new length scales for genome engineering sciencedirect.com/science/articl… 🧬💻🧪

Online Now! Development of human induced pluripotent stem cell-derived ovarian support cells as a clinical-grade product for in vitro fertilization dlvr.it/TQKpTb #stemcells

Targeting T cells by delivering mRNAs encoding DLL1, FLT3L and IL-7 to liver improved peptide vaccine responses and restored anti-tumour immunity in aged mice. #NBThighlight nature.com/articles/s4158…

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models go.nature.com/4gqhxvw rdcu.be/eUK5T

新刊『知識ゼロから始める　AIによる動物行動解析』が本日発行です📕 ☑️カメラや飼育環境のセットアップ ☑️DeepLabCutやYOLO，その他ツールの使い方 ☑️マウス・ラットの解析はもちろん，サルや魚，ハエ，線虫まで が詰まった日本初の動物行動解析の実践書🧐 発展として高精度な解析を自分で実装する方法や，委託解析もご紹介します😀 💻購入者特典として、プログラムコードがダウンロードできます yodosha.co.jp/jikkenigaku/bo… ※書店店頭に並ぶまでに時差があります。

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. biorxiv.org/lookup/content… The CRISPR toolbox has revolutionized the study of nuclear DNA, but the mitochondrial genome (mtDNA) has remained out of reach, mainly because there are no known ways to deliver sgRNAs across both outer and inner mitochondrial membranes. Yet many organisms have evolved mechanisms to transport RNAs across their mitochondrial membranes. Trypanosomes, for example, do not encode any tRNAs in their mtDNA, and must import all of them from the cytosol to support intra-mitochondrial protein translation. We started with yeast. We engineered a strain that must repair a STOP codon in mtDNA (an arginine biosynthesis gene) to survive. After screening a library of sgRNA import sequences, we identified one that enables a small degree of functional CRISPR editing in mitochondria. Graduate student Sifei Yin obtained these exciting results several years ago, and spent the intervening time understanding how sgRNA import works, and how to make it better. Read the paper to learn what she uncovered!

@todaimode すごい！おめでとうございます！

1週間の缶詰プログラム終了。英語ピッチで賞をいただき、なんと海外視察が決まりました👏冬のトロント？凍らないかな… とりあえず、プレスリリースでも出すかな…

【注目プレスリリース】ドローンで回収したザトウクジラのブローから新規のヘルペスウイルス遺伝子を発見 / 東京大学 research-er.jp/articles/view/…

A protocol for the robust generation of human #gastruloids, an important optimization needed by the field. This is not only a #protocol but also a reasoning behind it and a study of the initial conditions biorxiv.org/content/10.110…

Surprise: the classic differentiation driver let-7/miR-98 can induce naïve human PSCs. A short miRNA pulse + brief BMP cue flips primed → naïve—feeder-free, high efficiency. Workflow, scRNA-seq etc in the preprint: biorxiv.org/content/10.110… #miRNA #naïvehPSC #pluripotency #SynBio

Simplified In Vitro Generation of Human Gastruloids for Modelling Early Development biorxiv.org/content/10.110…

🚀 Big update to iDEP — our popular app for RNA-seq and omics data analysis. Visualize, analyze, & unveil pathways. In minutes! What’s new 1. Updated annotation of 13,000 genomes 2. Cleaner, faster UI with improved docs 3. Import external fold-change & p-value tables, then run clustering and pathway analysis. Why iDEP? iDEP brings together hundreds of R packages and thousands of annotation resources so any biologist can interpret RNA-seq data interactively. It is a massive Shiny app with a huge database, taking 8 years and over $1M to develop! Key features: 1. End-to-end workflow: exploratory analysis, differential expression, and pathway analysis for bulk RNA-seq or other gene-level summaries 2. Rich, interactive visuals: clustering, KEGG pathways, genome views, and more 3. Flexible use: run on the web, as an R package, or via Docker 4. Reproducibility by design: download the generated R code, data objects, reports If you work with RNA-seq or other omics data, give the new iDEP a spin—and let us know what you think! iDEP: bioinformatics.sdstate.edu/idep/ #RNAseq #Bioinformatics #Omics #Shiny #RStats #DataScience #Genomics #ReproducibleResearch

We created an abnormal mRNA by reversing the positions of the Cap and poly(A) tail. surprisingly, translation was still promoted by the Cap! This reveals an indirect interplay between Cap and poly(A).Published in Angewandte Chemie! onlinelibrary.wiley.com/doi/10.1002/an… #mRNA