Johannes Kaesmacher

We are hiring a Postdoc. Join the Pragmatic Evidence Lab @ Uni Bern. Apply now. ohws.prospective.ch/public/v1/joba…

Recanalization Is Not the End of the Story: What Early MRI Reveals About Hypoperfusion After Thrombectomy In this #BloggingStroke post, @karishma_popli discusses #Stroke article by ter Schiphorst et al. #ISC26 @AHAScience ahajournals.org/do/10.1161/blo…

The January episode of the #StrokeAlert Podcast is now available. In this episode, host @NAsdaghi highlights articles in the January issue of #Stroke and interviews @fwcavalcante & Prof. Charles Majoie about the IRIS meta-analysis. ahajournals.org/do/10.1161/pod…

Amazingly executed Michele! It's great to see growing evidence for the DOT ⚪️ Also thanks to @DOWindecker for his hard work on the inital DOT paper @StrokeBern @CheesemakerMD @TDobrocky @Eikeip @TotoMynell @DavidSeiffge @FishingNeurons

Why some #stroke patients worsen despite apparently successful thrombectomy? 👉 Focus: the Distal Occlusion Tracker (DOT) sign on post-MT flat-panel CT 🔰a thread on our newly published study in @JNNP_BMJ jnnp.bmj.com/content/early/…

🚀Breaking news🚀We would like to welcome the @DOIT_trial study teams in Ulm, Leipzig, Ludwigshafen, and Bad Neustadt to the @DOIT_trial community!🥳 we are thrilled to have you on board, actively screening and recruiting patients!

This topical review by Campbell et al. discusses the optimization of #stroke reperfusion trials, key imaging research priorities, and improved definitions for macro vs microvascular reperfusion. ahajournals.org/doi/full/10.11… @GeorgeHarston @PoojaKhatriMD @FishingNeurons @NguyenThanhMD

Presented at #SVIN25: CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: nej.md/3LK9kst Editorial: Managing Asymptomatic Carotid Stenosis nej.md/482XjG1 @svinsociety

🧠Study of patients who underwent intracranial stenting after EVT found no differences between those with vs. without IVT in: 🗓️90-day mRS shift 🗓️90-day mortality 🕐 24h sICH rates Read more here👇 journals.sagepub.com/doi/abs/10.117…

Excelente oportunidade e grande iniciativa!! 👏👏👏 @sheilambrasil @FishingNeurons

The DO-IT study is gaining momentum in Europe, and Canada is next! 🇨🇦 Are you ready to DO IT? 👍💪💉

In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. DO NOT ADD ASS TO (D)OAC for chronic CAD nejm.org/do/10.1056/NEJ…

🔊 Exciting DO-IT Trial Update!🔊 📈 🌍 The trial continues to expand, with 24 sites actively recruiting across Europe and 33 patients enrolled so far! - 27 in🇨🇭 - 3 in the 🇳🇱 - 2 in 🇧🇪 - 1 in 🇪🇸 👏 A big thank you to everyone contributing! 💉🧑‍⚕️Recruit. Care. Cure. DO-IT!

DETECT🩸🧠✨️ neurology.org/doi/10.1212/WN…

Cancer-related strokes are difficult to manage, synonym of bad prognosis and still poorly understood, which is why I did my clinical PhD on this exciting topic. It is now published online, check it out!😉: boristheses.unibe.ch/6822 @StrokeBern @MedFacultyUniBE

Excited to see our work "SWICH - a fully automated deep learning model for CT-based ICH segmentation" presented by @bmsiepen at the World Stroke Conference 2025 in Barcelona! 🎉 Open-access software available - contact our team to collaborate or try it out. #WSC2025

🚨new paper! Should stroke patients with tandem lesions undergo stenting during EVT? And does prior IVT matter? Find out below 👇 ahajournals.org/doi/10.1161/ST… #stroke @manonkappelhof @kiliantreurniet @CheesemakerMD @FishingNeurons

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This graph sums it up. In acute stroke with tandem lesions (ICA + intracranial occlusion), acute carotid stenting during EVT was associated with better 90-day outcomes than EVT without stenting. Outcomes were similar with or without prior IV thrombolysis (IVT). Caveat: secondary (post-hoc) IPD meta-analysis of 6 RCTs - stenting wasn’t randomized, so results are associative, not causal.

Disappointing negative outcome from the THEIA trial of IV alteplase vs aspirin in CRAO, albeit underpowered. Similar outcomes reported at ESOC 2025 in the yet published TenCRAOS trial of IV tenecteplase. Is intra-arterial thrombolysis the answer here? 🤔 thelancet.com/journals/laneu…