Thilo Womelsdorf

68 posts

Thilo Womelsdorf

Thilo Womelsdorf

@thiwomTO

Vanderbilt Univ, Nashville, TN Tham gia Nisan 2015
397 Đang theo dõi411 Người theo dõi
Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
Multi-Neuromodulatory fingerprints of an adaptive cognitive state: Cognitive engagement was predicted by joint GABA & ACh/Choline in PFC; by Dopamine & Cholinergic changes in striatum. Glutamate & ACh correlated across states. Kudos to team + Dr Pawliszyn biorxiv.org/content/10.648…
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
2/2 Abilities of inhibitory control, WM updating, and shifting distinguished cognitive phenotypes in NHP's; expl. factor analysis suggested 1) WM updating 2) Shifting/Learning, and 3+4) inhibitory control of interference from external vs internal sources are 4 sep. cogn. factors.
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
1/2 New paper supporting a 4-factor model of Executive Functions in nonhuman primates (NHPs) using a multi-task assessment approach. NHPs show consistent cognitive phenotypes: A first step quantifying the cognitive architecture in NHP biorxiv.org/content/10.648…
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
New IN review covering eTypes, mTypes and comp. motifs of prefrontal interneurons - @KiaBanaie et al. (2026) Prefrontal Cortex Interneurons and their Contributions to Attention, Working Memory, and Adaptive Behavior. Progress in Neurobiology, pubmed.ncbi.nlm.nih.gov/41478518/
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Martin Vinck
Martin Vinck@martin_a_vinck·
Now out - we show that PV and SOM inhibitory interneurons contribute synergistically to generate cortical oscillations at various frequencies (from gamma down to beta/alpha) and control network stability... cell.com/cell-reports/f… - with Farzin Tahvili and Matteo Di Volo - 1/3
Martin Vinck tweet media
Martin Vinck@martin_a_vinck

Unique functional roles of PV and SOM cells in controlling network oscillations and stability - the CAMINOS model fits a wide range of ephys and opto data and predicts hierarchical gradients in oscillation frequencies & seizure propensity based on SOM/PV densities and activation

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Kianoush Banaie Boroujeni
Kianoush Banaie Boroujeni@KiaBanaie·
🚀 🚀Preprint out now on bioRxiv! “KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking” Brings geometry-free, per-neuron drift correction, without uniform movement assumptions in large-scale recordings. 🔗biorxiv.org/cgi/content/sh… 👇Code + docs
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
Notable: mental re-ordering (swapping) was more likely with better learning the initial sequence (=memory) (otherwise NHPs keep using serial chaining strategy) and correlates with working memory performance - kudos to Xuan, Adam and Seema for pulling this off ! 2 / 2
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
New paper shows how nonhuman primates learn (5-) object sequences and use context cues to mentally re-order objects within a learned sequence – showing that NHPs form non-spatial cognitive maps 1 / 2 journals.plos.org/plosbiology/ar…
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
Overall, the effects suggests that stimulation induced uncertainty in the ACC (with few exceptions) and in striatum boosted feature-specific credit assignment and updating of attentional priorities. Kudos to Louis, Kia, Charlie, Adam and Paul for pulling this off.
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
Modeling suggests stimulation improved/impaired directed exploration/information gathering of relevant objects and the updating of feature values. Recordings showed ACC firing tracked feature uncertainty and error history, while striatum tracked stronger feature values of objects
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron cell.com/neuron/fulltex… 1/2
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Kari Hoffman
Kari Hoffman@perpl_lab·
What makes memories last—dynamic ensembles or static synapses? | The Transmitter: Neuroscience News and… disq.us/t/4r3afea Thanks to @JasonSynaptic for organizing!
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Saman Abbaspoor
Saman Abbaspoor@SAbbaspoor·
Excited to share that the latest @perpl_lab paper is published in @CellReports. We describe the dynamics of superficial and deep CA1 pyramidal cells and identified putative groups of inhibitory cells in freely moving, thinking, and sleeping macaques. 1/n
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
@PeterMKaskan @Hiroyuki_O please also send your study/abstract - ACC stim only impaired = Loss-of-Function... but we found an improving spot too... happy to talk/email about it, a good BRAIN conf.!
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
If you are interested in how the Anterior Cingulate Cortex affects behavior: Brief ACC-stimulation when an object is fixated changes inferring the relevance of that object over other objects, i.e. ACC reduces uncertainty about the objects' value. 1/3 biorxiv.org/content/10.110…
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Thilo Womelsdorf
Thilo Womelsdorf@thiwomTO·
The conclusion is the ACC causally meta-adjusts learning strategies during periods of uncertainty to infer which objects to choose/attend/explore for best outcomes. kudos to @LTreuting44120 and the team with @KiaBanaie to pull this off!! 3/3
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Khám phá

@KiaBanaie @perpl_lab @AymanAljishi @JasonSynaptic @CellReports @Hiroyuki_O @RussBEneuro @HelenMaybergMD