Alex Guet-McCreight

Thrilled to share our latest publication on predicting optimal doses of α5-GABAA receptor modulators for depression treatment using EEG biomarkers and computational models. #Neuroscience #Depression #ComputationalBiology #MachineLearning #EEG doi.org/10.1371/journa…

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity biorxiv.org/cgi/content/sh… #biorxiv_neursci

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory dlvr.it/T5RDx8

EEG biomarkers of GABA α5 positive allosteric modulators in rodents biorxiv.org/cgi/content/sh… #biorxiv_neursci

New CAMH-led research in @CommsBio shows targeting specific brain cells could be a game-changer for treating depression. By simulating pharmacology effects in humans, scientists are getting closer to more effective treatments. ⬇️MORE: doi.org/10.1038/s42003…

My Cerebral Cortex article finally moved from early release to an issue release (doi.org/10.1093/cercor…). Here is some nice cover art by Amanda Sherrington (galleriesherrington.ca) that we had hoped to publish alongside it (not selected, unfortunately).

I'm really proud to share this data paper on some of our human neuron intrinsic ephys work with @DrValiante, @moradi_homeira, and @internautderek that is now out at @GigaScience! academic.oup.com/gigascience/ar…

Excited to share this collaborative work, now in its final form: Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity. @CAMHResearch @KBI_UHN #aging doi.org/10.1093/cercor…

New work with @Kant_Yao: Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. 🥳doi.org/10.1016/j.celr…

@richardtomsett @neuronJoy @wake_sleep @DrValiante @bradleyvoytek Oh yea, links with papers from @bradleyvoytek have been on my radar. We can model EEG outputs from our circuit simulations, but opted to not include this here (primarily) since we model L5 and not a multi-layer circuit. Fig 3F (spike PSD) might offer a qualitative look into this.

New neuron modeling study on electrophysiological changes in aging from the lab of Etay Hay and collaborators @neuronJoy @DrValiante Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity biorxiv.org/content/10.110… #KrembilNeuroinformatics

#ArticlesinPress - "Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function" Alexandre Guet-McCreight and Frances K Skinner #Dendrites #Ionchannels #Neuroscience @UofT ow.ly/CTwP50FPXaO

Excited to share submitted work with @AlexGuetMcC on virtual inhibitory network modeling biorxiv.org/content/10.110… - made possible by building on collaborative work doi.org/10.3389/fncel.… and doi.org/10.1093/cercor… and more! #KCNhub @KrembilRI

Deciphering how specialized interneuron-specific cell types contribute to circuit function biorxiv.org/cgi/content/sh… #biorxiv_neursci

@Alex_Pierri_C @CPIN_UofT Thanks Alexandra!

Congrats to @AlexGuetMcC for his poster award @CPIN_UofT Research Day 2019! Much deserved to a multidisciplinary poster bridging heavy computational simulations of IS3 cell recruitment in vivo with calcium imaging experiments. Detail and thoroughness pay off! #KCNhub #KrembilRI

UofT CPIN joins us to a packed house for Dr. Eve Marder's keynote talk at #Krembil Research Day

Giant neuron found wrapped around entire mouse brain like a 'crown of thorns': go.nature.com/2l7Ur1c

Neuroscience's Grand Question neurosciencenews.com/theoretical-ne… #neuroscience