Andy Shih

@DAgalliu Thank you, Dritan!

Congratulations Andy! It’s very nice work!

Happy to see this work finally published 🙌!! A team effort with @AndyShih_Lab!! We show that from birth to old age, #microglia 🧠 undergo striking shifts in morphology, complexity, and injury response. #liveimaging #neuroimmune #neonatalbrain #agingbrain

@eyolab Thank you for sharing the work @eyolab!

New work from @AndyShih_Lab's group is incredible & shows that some of the in vivo imaging done to study neurovascular physiology is literally just "scratching the surface" as this deep imaging shows differences in flow regulation in deeper brain regions: nature.com/articles/s4159…

It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination. nature.com/articles/s4159…

Groundbreaking scientific discoveries don’t happen in isolation. Michelle Gray, PhD, SfN Program Committee member, shares how you can enhance your research through valuable exchange w/ the scientific community at #SfN25. Submit your abstract today! 🔗 bit.ly/4juLSLs

Very happy to share @stephkbeee's study in @PNASNews on the effects of capillary injury in the brain. Protect those heads! Stephanie is starting her own lab at @CUAnschutz soon and excited to see her research grow!

Growth hormone acts on #pericytes, stimulating #angiogenesis and supporting #oligodendrocyte survival & growth after neonatal hypoxia. An impressive study by the Mei Lab (cell.com/neuron/fulltex…) in @NeuroCellPress. Preview written with @vcoelhosantos (cell.com/neuron/abstrac…)

@stephkbeee @SiegenthalerLab @sosamariaj @NielsonCara @stephkbeee, it's so exciting to see your dream come true after all the long hours in the lab. You will be an amazing PI and I'm excited to see your research grow! Prospective trainees, keep your eyes on the future Bonney lab for cool imaging projects!

I have soooo many people to thank for all their guidance and support along the way, most of all my mentors @AndyShih_Lab and @SiegenthalerLab. And my amazing colleagues @sosamariaj and @NielsonCara for going on crazy adventures with me in the Shih Lab.

I am thrilled to share that the Bonney Lab will be opening its doors come January @CUAnschutz in the department of Anesthesiology! We will study perivascular pathology in cerebral small vessel disease using in vivo and ultrastructural imaging approaches.

@OrlaBonBon @stephkbeee Orla, it was so much fun that the time flew by too quickly. The van Veluw lab is very lucky to have such a great scientist and thoughtful team member!

Saying goodbye to Seattle today after a wonderful 6 weeks in @AndyShih_Lab. Thank you for having us and thanks to @stephkbeee for taking me under her wing in the lab. So much great science, sooo many beautiful images taken and a lot of fun ✨ Until next time! ✨

@MSEFulton Such a cool image, Mia! Looking forward to hearing more in the future!

Check out this beautiful image I took of pericyte sprouting from blood vessels in retinas from diabetic animals treated with a FDA Approved Phase III Clinical Trial drug after stroke! 😍🧬 I was inspired by @AndyShih_Lab 😀 #Strokerecovery #BrainHealth #diabetes #vascularhealth

@nickchavkin @uwpediatrics Yeah @nickchavkin! Congrats and looking forward to welcoming you to the SCRI family soon!

Exciting news to share - I accepted an Assistant Professor position to start my lab at Seattle Children's Research Institute and @uwpediatrics! I start on July 1st in the Center for Developmental Biology and Regenerative Medicine. chavkinlab.com

@Nrklug The pleasure was ours, Nick! Excited to see future work from your new lab. Your techniques are awesome. Come back and visit soon.

What a privilege it was to spend an entire week with @AndyShih_Lab. The lab is filled with amazing people doing fantastic science. I can't wait to take what I have learned back to UVM.

@AllenInstitute Thank you for sharing @AllenInstitute !

Check out this new study by @AndyShih_lab, our own Kevin Takasaki, and others on the relationship between age and blood circulation in the brain.

@neurodevKathy Thanks for the support Kathy!

@Nrklug @franca_schmid @AllenInstitute @HannahCBennett7 @yongsookimlab @stephkbeee @sosamariaj @JennyYuandongLi Thanks Nick! Lets try some deep imaging when you visit the lab.

@AndyShih_Lab @franca_schmid @AllenInstitute @HannahCBennett7 @yongsookimlab @stephkbeee @sosamariaj @JennyYuandongLi Congrats to Stefan, Nicolas, you, and the whole team! Impressive all around!!

What makes cerebral white matter more vulnerable with age? In this mouse study, we show that large and rare venules are bottlenecks for blood flow in the white matter. Deep branches of these venules are constricted with age, leading to reduced blood flow. biorxiv.org/content/10.110…

@AmrnMughal Thank you Amreen! Also, I see you have started your new lab! You deserve the REAL congrats! Happy to talk imaging and veins/venules in the future.

@Wilcock_v2 Thanks so much Donna!

As always, @AndyShih_Lab elegantly shows us how consequential cerebrovascular injury can be! Congratulations!

@alankrit97 Thanks Alankrit. It's possible that some out of focus damage occurred, but if the concern was inadvertent, direct damage to arterioles, it is less likely. The selected capillary targets were not underneath pial vessels, and distant from the transitional zone in the x-y dimension.

@AndyShih_Lab Hi Dr. Shih, great work by your lab, again! I haven't gotten into the details of the study yet but I would assume that 100 mW power exposure at 200 um would cause damage to the surface vessels. Was that observed?

It's all connected... In this study, we show that tiny injuries created deep in the brain's capillary bed can contribute broadly to blood flow impairment by constricting upstream supply vessels. biorxiv.org/content/10.110…