Kemper Complement Lab

Noncanonical roles of #complement: #BriefReview by @CKemperLab Viviana Ferreira, @JeanneTPaz V. Michael Holers, @LionakisLab & Jessy Alexander | #ReadTheJI #fungalimmunity #neuroimmunity @NIH @UBuffalo @UToledoMed @GladstoneInst @CUAnschutz 👉 ow.ly/g55F50MqOUH

Thank you for the congrats on the paper - true collaboration effort between the Zhang and Kemper labs and spearheaded fantastically by Jack (@jackabibby) and Divyansh (@divyansh_aga). Happy Thanksgiving to all.

You can find the SCPA R package here: jackbibby1.github.io/SCPA/. It was a big collaborative work with @NancyZh60672287 and @divyansh_aga, and thanks to everyone involved (-- people on twitter: @AfzaliBehdad, @tilofrei, @NicolasSMerle)

Hi all. We're happy to share our latest paper, just published in @CellReports. We developed a scRNA-seq pathway analysis package and applied it to look at T cell activation in vitro and in tissue. Here's the paper: cell.com/action/showPdf….

Excited to share my group's first pre-print from the @MRC_WIMM. We screened ~7000 genes for their roles in blood stem cell differentiation in vivo: biorxiv.org/content/10.110… We also made a webapp resource so you can search for your favourite genes: hematopoiesiscrisprscreens.com 1/3

Happy and proud to share that our amazing colleague and friend Susan Lea is now an elected Fellow of the Royal Society - congrats from all of us! @S_M_Lea @royalsociety

On behalf of the #ICS many thanks to our superb speakers at #AAI2022: @JessyAlex9 Jeanne Paz, Michael Holers and @LionakisLab. #complement continues to go from strength to strength.

The sixth and final session of #KSINNATECOMP22 @KeystoneSymp explores the “Roads less Traveled – Emerging new Paradigms” in Complement and Beyond.

Great short talks at #KSINNATECOMP22: Marlene Kanmogne @MarleneKanmogne demonstrated a protective role of C3aR during West Nile Virus neuroinvasive disease and Yingying Zhang used MERFISH to profile the complement system in brain development.

Jonathan Kipnis @jonykipnis @kipnislab presented some seriously cool insights into the Brain-Immune axis! #KSINNATECOMP22

Here’s a few Complement puns from the Napier Lab Slack account #KSINNATECOMP22

More beautiful minds at #KSINNATECOMP22: Dori Schafer @SchaferLabUMCMS demonstrated how C3 inhibition at synapses prevents synapse loss in neurodegenerative diseases and Andrea Tenner @andrea_tenner revealed how C5aR targeting controls neuroinflammation in Alzheimer’s.

Serious discussions ⁦@KeystoneSymp⁩ #innate and #complement ⁦@SchaferLabUMCMS⁩ ⁦@jonykipnis⁩ ⁦@danielsaloreich⁩ ⁦@KannegantiLab⁩

Fortuitous partial meet-up of the @NIHOxCam ExComm in Snowbird Utah @CKemperLab @storzlab @TheAlliance05

Fantastic Complement and beyond @KeystoneSymp #KSINNATECOMP22 Thanks @CKemperLab and @cj_binder for organizing it and to the whole team of the logistics. Great program! Looking forward to the next one!

Nathalia Kunz from @CKemperLab convinced us that cd46 cytoplasmic tail cyt1 has striking functions regulating cell physiology. Finishing in beauty the last session of #KSINNATECOMP22

Session 5 of #KSINNATECOMP22: “Complement makes for a beautiful mind” just finished! Daniel Reich @danielsaloreich started the session with a fantastic talk exploring complement-mediated chronic inflammation in multiple sclerosis.

Excited about the last day of #KSINNATECOMP22 featuring sessions focusing on Complement functions in the Brain and Emerging new Paradigms in Immunology!

The second day of #KSINNATECOMP22 ends with a great presentation by Markus Bosmann exploring C5aR redundancy in lung injury and infection. #Complementbiology

Lubka Roumenina @roumenina beautifully demonstrated that the role of Complement is absolutely context dependent and introduced an exciting new integrative concept, the Complomentome. Very intriguing! #KSINNATECOMP22 #Complementbiology