Cassa Lab

I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og_4GsWeU0 🧵

Congratulations @FedeLuppi2 and @agnestothp on this impressive project to improve pathogenicity prediction using structural and epistatic features in clinically significant genes!

📢New work from our lab in @NatureComm! Our article describes PepSEq, a high-throughput approach to measure influences of peptide fusion on prime editing efficiency. 🎉Joyful effort by members of our lab led by @minja_bio nature.com/articles/s4146…

@valkanase Now you are going to get some special cat requests!

How unprofessional is it when a cat interrupts zoom meetings? I blur the background, but she has no manners and a cat butt is unmistakable.

New work from our lab showing that use of small molecule inhibitor can change mutational outcomes of both SpCas9-NG and KKH-SaCas9 toward 1-bp insertions. nature.com/articles/s4146…