Peggy Goodell

An interesting question not addressed is the lifestyle differences of people with inactivating myostatin variants. You might guess that people with more muscle will excel in activities where those traits are valuable (e.g., athletics or certain jobs). Those activities might be self-reinforcing, further enhancing muscle growth and amplifying the apparent genetic effect over time. Lots more to learn, but a great investigation that will move the field forward. #aging #muscle #health

It’s also a testament to the incredible societal value of these huge biobanks, the careful genotyping, thoughtful phenotyping, and mechanisms to make these available for analysis. THANK YOU to everyone who participates as a subject, to all the researchers who have worked so hard on these incredibly valuable resources, and to the funding bodies with foresight to invest in these. UKB and similar are truly transformative IMO.

Remarkable new study showing that many individuals with genetic variants that disrupt the function of myostatin (a protein that normally inhibits muscle growth) have ⬆️muscle mass,⬇️ body fat, and ⬆️strength. Increased muscle mass is clinically desirable for #healthyaging and for countering muscle loss in various contexts (including use of #GLP1 agonists). Below, MRI images of a subject with above-average muscle mass (left) and average muscle mass (right) from the study. Congrats @davidjglassMD and colleagues! Link ⬇️

@AbdelWahablab @natgenet @KellyLBolton @WashU @IrenaeusChan @PuZhang09980432 Congrats all! Glad to see this out!

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s4158…

Important work w real translational potential for cancer patients. Built on foundational science developed over years. Congrats to all!

@yash_pershad @AlexBickMDPhD @VanderbiltMSTP @joevanamburg @rheumrob @brettheimlich Congrats, Yash! - and to Alex! You have impacted so many projects (including ours) in your PhD! I look forward to seeing what next!

Excited to share that I defended my PhD in Human Genetics 🧬 I am immensely grateful to my mentor @AlexBickMDPhD, my family, my co advisor Dan Roden, my labmates, the @VanderbiltMSTP, our amazing collaborators, my committee, and everyone who has supported me!

Somatic genomics as a discovery engine for biomedicine - a Perspective in Cell sciencedirect.com/science/articl…

Amazing new findings on clonal evolution by @jrblundell and team. #dnamethylation barcode for clonal collapse.

@nancykgillis @NatureGenet Congrats! Looking forward to reading this!

📢 Our review on clonal hematopoiesis + evolutionary dynamics using mathematics is now available online @NatureGenet Check it out! #CHIPsm

#FromSketchToCover ✨ For the cover of @MolSystBiol Molecular Systems Biology (Vol. 19, Issue 3), we adapted Hope II by Gustav Klimt into a scientific visual language. The goal: preserve the themes of pregnancy, vulnerability, and protection, while translating them into a story about placental immune modulation by Group B Streptococcus. Art history meets molecular systems biology! 🔗 link.springer.com/article/10.152… #SciArt #ScientificIllustration #SciComm #JournalCover #DrawImpacts

Great study on resilience and survival of stem cells in aging muscle! #aging

And co-organized by @bloodgenes !

Hematopoiesis meeting👇 keystonesymposia.org/conferences/co…

Excited to be speaking at the upcoming @KeystoneSymp on 🩸Hematopoiesis 🩸Feb 23-26 organized by @BeaudinLab and Esther Obeng. Poster abstracts due Feb 3. All-star cast w/ great science and networking! Doubleheader 2-for-1 with Myeloid Cells mtg!

Myeloid meeting 👇 keystonesymposia.org/conferences/co…

@CalebLareau @MSKCancerCenter Amazing impactful work- huge Congrats!

Grateful to work everyday at @MSKCancerCenter as a home to conduct this research. A write-up of the effort in context of our group's efforts to understand the virome is covered here: mskcc.org/news/genomics-…

⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s4158…