vittorio

𝕏 is reportedly developing AI-generated content detection features that will prompt users with a warning before allowing them to post.

Normies have no idea what is coming next… 🛢️📈📈📈📈

Go to the Gym

Finally achieved the holy trinity of longevity. Home Gym. In home dry sauna. In home Hyperbaric chamber. Red light therapy. 5-6x a week. I'm living to 300 or going to die trying.

babies coming in the morning. please say a prayer for my wife and family. or send me 1000 USD. whatever your heart tells you

JUST IN: New York City reportedly now spending more per homeless person than the median income of the city.

my conspiracy theory officially, less than 1% of women wanted this. it passed after 46 minutes of commons debate, without public consultation or evidence sessions, it was tagged onto a crime and policing bill while being the biggest change to abortion law since 1967 this is the same country that spent a decade covering up industrial scale raping gangs because they were afraid of "community relations" women getting pregnant from rapes nobody would prosecute, unable to legally terminate, ending up in courts that force questions nobody in government wants to answer so what do you do. you can't face the gangs issue because that means facing the corruption and the coverups. you can't arrest the girls because that leads back to the gangs again. so you make the abortions legal and stop talking about the rapes

my conspiracy theory officially, less than 1% of women wanted this. it passed after 46 minutes of commons debate, without public consultation or evidence sessions, it was tagged onto a crime and policing bill while being the biggest change to abortion law since 1967 this is the same country that spent a decade covering up industrial scale raping gangs because they were afraid of "community relations" women getting pregnant from rapes nobody would prosecute, unable to legally terminate, ending up in courts that force questions nobody in government wants to answer so what do you do. you can't face the gangs issue because that means facing the corruption and the coverups. you can't arrest the girls because that leads back to the gangs again. so you make the abortions legal and stop talking about the rapes

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

The total number of smart people in the world has just peaked. And now it's about to crash.

Global population to shrink this century as birth rate falls. The world is set to have 200 mn fewer people than previously expected by 2100. Fertility rates have fallen below the replacement rate in most continents.