Kyle Hewitt

Here are 30 great essays about biology. I consider these to be my "personal canon," and think that they are all basically perfect in their own ways, despite being different in form and style. All have shaped my own writing considerably. I'm not including links here, but you can easily search and find these. 1. Diagnosing the decline in pharmaceutical R&D efficiency, Jack W. Scannell et al., 2012 2. Predictive validity in drug discovery: what it is, why it matters and how to improve it, Jack Scannell et al., 2022 3. Is the cell really a machine?, Daniel J. Nicholson, 2019 4. How academia and publishing are destroying scientific innovation: a conversation with Sydney Brenner, Elizabeth Dzeng, 2014 5. A Future History of Biomedical Progress, Adam Green (Markov), 2022 6. The pharma industry from Paul Janssen to today, Alex Telford, 2023 7. The Lives of a Cell, Lewis Thomas, 1974 8. The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades, Sharon Begley, 2019 9. The Scientific Virtues, Slime Mold Time Mold, 2022 10. First Clean Water, Now Clean Air, Fin Moorhouse, 2023 11. I should have loved biology, James Somers, 2020 12. The Baffling Intelligence of a Single Cell, James Somers & Edwin Morris, 2024 13. Biology is more theoretical than physics, Jeremy Gunawardena, 2013 14. Can a biologist fix a radio?, Yuri Lazebnik, 2002 15. Cells are very fast and crowded places, Ken Shirriff, 2011 16. Life at Low Reynolds Number, E.M. Purcell, 1976 17. Lena, qntm, 2021 18. Sequences and Consequences, Sydney Brenner, 2010 19. The NIH Report, Matt Faherty, 2022 (I edited this one) 20. Simplicity in biology, Uri Alon, 2007 21. A breakthrough from 60 years ago: “General nature of the genetic code for proteins” (1961), Matthew Cobb, 2021 22. Molecular “Vitalism”, Marc Kirschner, John Gerhart, Tim Mitchison, 2000 23. The Coming Technological Singularity, Vernor Vinge, 1993 24. Review of Scientific Self-Experimentation, Brian Hanley & William Bains & George Church, 2018 25. Coming full circle-from endless complexity to simplicity and back again, Robert Weinberg, 2014 26. Nothing in Biology Makes Sense Except in the Light of Evolution, Theodosius Dobzhansky, 1973 27. The Impersonator: The Fake Data Were Coming From Inside the Lab, Uri Simonsohn, 2024 28. The Longevity FAQ, José Luis Ricón (Nintil), 2020 29. The Perfect Human is Puerto Rican, Lior Pachter, 2014 30. No Evidence of Disease, Stephanie Bourque, 2012

1/ Excited to share CellFlow, a new approach for complex perturbation modeling in single-cell genomics based on flow matching. From cytokine screens to cell fate and organoid engineering, we show CellFlow’s broad power across many diverse tasks. 👉 Paper: biorxiv.org/content/10.110…

This seems like a fundamental misunderstanding of the process of grant review, probably because the people making decisions just don't know.

Indirects were due for a substantive reckoning at some point, but indiscriminate and immediate cuts don't make sense.

Looking forward to hosting @theclotthickens in our GCBA seminar series! 👇

3/ 3) .... Rahul Dogiparthi presents a poster that describes a novel approach to prioritize and ascribe function to signal-responsive enhancers in the genome. Check it out.

2/ 2) Meg Schaefer presents her poster on a protein called SAMD1 and how it controls histone methylation...

1/ Graduate students in the Hewitt Lab @UNMCCOM are presenting three times at ASH #ASH2024! Come see us: 1) Pooja Roy @PoojaRoy96 is presenting in the oral abstracts session of the 101. She'll talk about her work on Samd14 in stress erythropoiesis

@UNMC_GCBA Congrats Nichole! @unmc_success @ND_brandquist @KielianLab

Congratulations to Nichole Brandquist on successfully passing her comprehensive exams! Nichole is a MGCB PhD graduate student in Tammy Kielian's lab.

Looking forward to this. 👇

@MJordanRowley Congratulations! Hannah did an excellent job.

Congrats to Hannah for defending her dissertation early this week! So very proud of the first to defend from my lab!

We are hiring at the Assistant Professor level at @TuftsUniversity #BME! If you are on the market this year and looking to join a collaborative R1 school with fantastic colleagues and students, give us a look! #TenureTrack | @TuftsBME | @TuftsEngineer apply.interfolio.com/153806

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@AshaniTW @ISEHSociety Yes! I miss Baltimore.

@LabHewitt @ISEHSociety Next stop, Baltimore to see your postbac mentor?

It was nice to see my postdoc mentor and former lab mates in the Bresnick lab. Awesome food and company. @ISEHSociety

@SignerLab @ISEHSociety Great talk Rob, and a well-deserved recognition of you wok.

Honored & grateful to deliver the #ISEH2024 Janet Rowley Award Lecture this morning. Excited to talk about our team, their discoveries & what amazing humans they are. Huge thank you to @ISEHSociety, our @SignerLab team, family, friends, mentors, colleagues & funders. 🙏

This was an excellent symposium. Happy to be able to present a collaboration between our group and @RKateHyde using organoids to mimic hematopoiesis in a dish.

Great advice! 👇

@imgurupen78 Congrats to you as well for great mentorship!

@LabHewitt Thank you @LabHewitt for your time and efforts over the last few years as a key committee member on her dissertation which were really helpful in her graduate journey. I really appreciate it 🙏

Great job, Dr. Nguyen! Congratulations.