John Pascal Lab

Online Now: PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) dlvr.it/TG7yqg

TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects! Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…

I’m extremely proud to share that my first first author paper was published today. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP academic.oup.com/nar/article/do…

Our latest paper on PARP2 is now out! Thanks to @zha_lab for a very nice collaboration. Clinical PARP inhibitors allosterically induce PARP2 retention on DNA science.org/doi/10.1126/sc…

New dropbox has been set up at the University of Montreal @UMontreal in Montréal, QC! Pickups are Fridays at 2pm, located in Room 2057, Pavillon J.-Armand-Bombardier. Thanks to John M. Pascal for hosting this new box! 🥳🥳🥳

Check our latest work on PARP2 and PARP inhibitors. Great collaboration with @zha_lab! Clinical PARP inhibitors allosterically induce PARP2 retention on DNA biorxiv.org/content/10.110…

We have a position open for a postdoctoral scientist. The projects in the lab focus on structural biology of ADP-ribosylation and drug discovery. #parp #fbmm #structuralbiology rekry.saima.fi/certiahome/ope…

Does distinct end of poly(ADP-ribose) matter? @LabPascal and our lab @DasovichMorgan @IsabelRUribe @SJCHENG1 found antiviral PARP13 binding to 2' end of PAR in an unexpected way. Excited to see our technology to label both PAR ends come to good use! cell.com/cell-reports/f…

@AmandaRiccioPhD @PNASNews Congrats!!

We are so excited to present “Structural insight and characterization of human Twinkle helicase in mitochondrial disease” in @PNASNews pnas.org/doi/10.1073/pn…

We are excited to share our latest structural study on PARP1 mechanism of activation! Cheers to @IcrLordLab for a nice collaboration! AddThis | Home authors.elsevier.com/a/1fMUZ3vVUPK8…

@MichaelNADbio Thanks Michael, Susan and Andreas for a organizing a wonderful conference! It was great to see everybody!

Happy to share our first Cryo-EM structure! Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase cell.com/structure/full…

Our new paper on PARP1/2 and HPF1 is out @Naturecommunications! HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications disq.us/t/42yjt6d

Check out our latest story on HPF1 regulation of PARP1/2!