MGH JWChen Lab

Grand opening of the i3, with Dr. Dubach, Associate Director of the i3, discussing i3 services, facilities, and equipment. @JimBrinkMD @MGH_RI @MGHImaging

Grand opening of the i3, with Dr. Brink, Chief of MGB Enterprise Radiology, describing the founding of the i3. @MGHImaging @MGH_RI @JimBrinkMD

Grand opening of the i3, with Dr. Arnold, Executive Director of the CTRU, describing the collaboration between i3 and IBC to form the CTRU to provide translational clinical research services. @MGH_RI

Grand opening of the i3, with Dr. Caravan, Co-Director of the i3, giving examples of translational work and first-in-man studies. @JimBrinkMD @MGH_RI @MGHImaging @PeterCaravan

Grand opening of the i3, reception, with everyone having a great time. @MGH_RI @MGHImaging

Grand opening of the i3, with Dr. Chen, Co-Director of the i3, giving an overview of the i3. @MGHImaging @MGH_RI @JimBrinkMD @MGHChenLab

Grand opening of the i3, ribbon cutting, with Drs. Brink (center), Rosen (left), Weissleder (right), Caravan (far left), and Chen (far right). @JimBrinkMD @MGH_RI @MGHImaging @WeisslederLab @MGHCSB @MGHChenLab

In this editorial, Dr. Chen discusses results from the article by Akai et al. on mouse model investigation of gadolinium brain deposition and behavioral testing, as well as the safety and medicolegal impact of these results. bit.ly/3gPgGss @MGHChenLab @HarvardMed

Myeloperoxidase, a highly oxidizing enzyme, exerts anti-tumor activity in glioma after radiotherapy. This could help optimize host immune response and therapy for this devastating disease. sciencedirect.com/science/articl… @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH

D-mannose, a commonly available dietary supplement and a simple sugar, can improve neuroinflammation by suppressing oxidative stress and blocking phagocytosis. doi.org/10.1073/pnas.2… @PNASNews @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH @CaravanLabMGH

Great symposium on translational imaging of inflammation coming up at the end of October. Hope to see you there! i3.mgh.harvard.edu/inflammation/ @i3Symposium2021 @MGHCSB @MGHImaging @MGHMartinos @MGH_RI @MGHNeuroRad @JimBrinkMD @MatthiasNahrend @SwirskiLab @mghradchiefs @UCSFimaging

Does gadolinium deposition in the brain have clinical consequence? Lessons from animal studies. doi.org/10.1148/radiol… @radiology_rsna @MGHImaging @MGHCSB @i3MGH @MGH_RI @MGHNeuroRad

A more powerful molecular MRI agent (4-10X higher than conventional MRI agents) to report on myeloperoxidase activity, which reflects oxidative stress and damaging inflammation. doi.org/10.1021/acs.jm…. @MGHImaging @MGHCSB @MGHNeuroRad @harvardmed @MGH_RI @JMedChem

Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know ajnr.org/content/early/… @AJNR @MGHCSB @i3MGH

Happy Holidays!

A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales thno.org/v09p7525.htm #Theranostics @Theranostics_J @i3MGH @MGHCSB @MGHImaging @MGH_RI @MGHNeuroRad

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo pnas.org/content/116/24… @PNASNews @MGHCSB @MGHImaging @i3MGH @MGH_RI @MGHNeuroRad