Richard Burman
212 posts
Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information. biorxiv.org/content/10.110…
Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimondo lab, we developed the all-optical approach ORCHID - all-Optical Reporting of CHloride Ion Driving force. Now out in @NatureComms nature.com/articles/s4146…
Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information. biorxiv.org/content/10.110…
We are excited to present ORCHID, a new tool for all-Optical Reporting of Chloride Ion Driving force. bit.ly/45P6est In the brain, inhibition is mediated by Cl- permeable receptors. ORCHID can therefore be used to quantify the driving force across inhibitory receptors.
Seizures that won't stop - status epilepticus - are a medical emergency. We have some good treatments available, but for some patients these don't work. Here's Tommaso Fedele and @RichBur trying to figure out why some treatments fail for some patients. medrxiv.org/content/10.110…
A small subset of meningiomas metastasise extracranially. The outcomes for these patients are poor and there are no effective management options at present. We present a case series and systematic review of the literature to describe their features. link.springer.com/article/10.100…
Following up on our discovery that cortical intracellular chloride changes with wakefulness, we now look into how this dynamic affects synaptic plasticity mechanism. Metaplasticity of cortical glutamatergic LTP by diurnal intracellular chloride dynamics biorxiv.org/content/10.110…
Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information. biorxiv.org/content/10.110…
