Robyn Kosinsky

Check out our commentary on spatial transcriptomics published in Clinical and Translational Medicine (doi.org/10.1002/ctm2.1…) . This methods allows us to analyze gene expression patterns in a tissue sample while preserving spatial information

An old bisphosphate friend may help to alleviate the burden of senescence: Samakkarnthai et al. demonstrate this in vitro and in vivo biorxiv.org/content/10.110… @Samakkarnthai @MayoClinic @skhosla78 @MadisonDoolitt3 @sfeirjad @Japneet__Kaur_ @NKLeBRASSEUR @aging #bone #aging

What happens if you remove senescent cells from bone locally as compared to systemic senolysis? Amazing work by Farr and the Khosla Lab: JCI - Local senolysis in aged mice only partially replicates the benefits of systemic senolysis jci.org/articles/view/… @jclinicalinvest

🚨In this month’s edition of @AGA_Gastro our group @FaubionWilliam Lab, shows how inhibitors of the epigenetic enzyme G9a can metabolic reprogram Tcells into Treg capable of controlling Intestinal Inflammation. Cell engineering & Epigenetic Modulation as potential novel #IBD txs

Ever wondered why some bones 🦴do not heal? We outline answers from basic research and the clinic: Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions—Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors mdpi.com/2058992

Awesome presentation by @skhosla78 on fracture healing and the impact of p21-driven cellular senescence at @ASBMR #ASBMR2022,thanks to @MadisonDoolitt3 @Japneet__Kaur_ @RobynKosinsky and the KhoslaLab #fracture #bonehealing #aging #senescence #science #research #bone @MayoClinic

Do you want to detect senescent cells in your sequencing dataset? Or monitor your senolytic therapy? SenMayo can help you: rdcu.be/cTL9h @natcomms #senescence #aging #research #SASP #Bioinformatics @NextGenSequence @skhosla78 @MadisonDoolitt3 @RobynKosinsky @PassosLab

Doolittle et al. use a new ERαΔOcy mouse model to decipher the mechanism of ERα action in bone: Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice asbmr.onlinelibrary.wiley.com/doi/10.1002/jb… #bone #jbmr #estrogen @skhosla78 @MadisonDoolitt3 @Japneet__Kaur_ @MegVoda

@DS8874945102 @OrthoToday @MayoClinicEndo @MayoClinic @skhosla78 Congratulations!

Check out our review in #EndocrineReviews: Fracture healing and how it is affected by endocrine diseases, aging, and cellular senescence: academic.oup.com/edrv/advance-a… #fracture #Healing #bonehealing #bone #aging #senescence @OrthoToday @MayoClinicEndo @MayoClinic @skhosla78

Interested in spatial omics? Plz check out our squidpy tool, bringing together omics & image analysis to enable a scalable description of spatial molecular data. Out today @naturemethods thx to @g_palla1, @HannahSpitzer1 & team! nature.com/articles/s4159… github.com/theislab/squid…

Inflammation in the gut is encoded by neurons in the brain go.nature.com/34tetPR

Senescence is more than just p16 and p21: We developed an in silico approach to reveal cells high in the SASP. SenMayo🧑‍🔬 biorxiv.org/content/10.110… #aging #senescence @MayoClinic @SingleCellMedia @scell_papers @skhosla78 @MadisonDoolitt3

We linked aging to cancer on a single cell level: Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations 🧬🥼mdpi.com/1353560 #mdpicells #aging #Cancer @scell_papers @ScPapers @MayoClinic

Happy to share our latest work about CRP in primary hip arthroplasty: mdpi.com/1331618 #mdpijcm via @JCM_MDPI Here we develop an algorithm predicting an early infection after hip arthroplasty at day 5 with a sensitivity of 87.5% 🧐💪 #orthotwitter #surgery #CRP #infection

@DS8874945102 @eLife @skhosla78 Congratulations!

Very happy that our eLIFE paper is finally out: We demonstrate for the first time that senescent cells accumulate in the fracture callus. Their clearance improves bone healing. doi.org/10.7554/eLife.… @eLife #khoslalab #bonehealing #fracture #mayo #orthotwitter @skhosla78

@DS8874945102 @ASBMR @MayoClinicEndo @MayoClinic @uniGoettingen @MadisonDoolitt3 Congratulations!!! 🎈

Happy to receive a Young Investigator Award @ASBMR 2021 @MayoClinicEndo #agingresearch #SanDiego @MayoClinic #ASBMR2021 @uniGoettingen