AgingResearch

Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications eurekaselect.com/article/136431

CellBiAge: Improved single-cell age classification using data binarization cell.com/cell-reports/f… @CellReports

Implication of Oxysterols and Phytosterols in Aging and Human Diseases link.springer.com/chapter/10.100…

Targeting the redox system for cardiovascular regeneration in aging onlinelibrary.wiley.com/doi/full/10.11…

USA needs to improve its medical care

A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease pnas.org/doi/10.1073/pn… @PNASNews

Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells link.springer.com/article/10.100…

Hyperhomocysteinemia and Accelerated Aging: The Pathogenic Role of Increased Homocysteine in Atherosclerosis, Osteoporosis, and Neurodegeneration pubmed.ncbi.nlm.nih.gov/37605676/

Switching astrocytes from expressing APOE4 to APOE2 reduced plaques, gliosis, and bettered memory in a mouse amyloidosis model. This may help guide APOE replacement therapies. #AAIC2023 ow.ly/7yfZ50PCzB9

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease nature.com/articles/s4158… @NatRevMCB

Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans "A possible mechanistic explanation for this finding is that ether lipids are required for activation of longevity-promoting, metabolic stress defenses downstream of the conserved transcription factor skn-1/Nrf...." elifesciences.org/articles/82210

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired buff.ly/3EaaVAx (@NatureComms)

New! Online now: Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease dlvr.it/StynhD

Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis pubmed.ncbi.nlm.nih.gov/37357334/

How old is your heart? We looked at genetic differences and risk factors that affect the age of the heart and circulation. Our new paper in @NatureComms points to genes regulating inflammation and stress response. #whyCMR nature.com/articles/s4146…

impetusgrants.org/apply @impetusgrants applications are now open (1-31st of August) If you are a scientist but you never worked on aging. If you are a Ph.D. student with good ideas. If you are a postdoc deciding on the direction of your future lab. Come join the good pursuit. We don't look for credentials and direct experience in aging. Only excellent ideas and the ability to get things done. impetusgrants.org/news-and-updat… - also wrote a note on the types of things that tended to succeed with Impetus in the past

DNA spill from mitochondria into the cytosol of microglia triggers cGAS-STING causing inflammation and faster ageing in mice. Do STING inhibitors have the potential to slow down brain ageing and associated pathology? It seems to work in mice. Soon someone will test it in humans. Nice In-the-pipeline blog post by Derek Lowe (science.org/content/blog-p…) on a recent Nature article by Gulen et al. (nature.com/articles/s4158…). The illustration below is from the accompanying News and Views by Bart Eggen (nature.com/articles/d4158…).

Human mitos can alter their local redox environment by selectively uptaking oxidized NAD+. Find out more about the molecular mechanisms of this regulation, as well as the influence from the local lipid environment embopress.org/doi/full/10.15…

Cryptic RNAs in Alzheimer’s brains with TDP-43 pathology! New work from @PrudencioLab and wonderful colleagues at Mayo Clinic! Shout out to Virginia Estades Ayuso, her first author publication! …arneurodegeneration.biomedcentral.com/articles/10.11…

Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood 🔎Epigenetic age gap (EpiAGE) shows a "small relationship with accelerated brain aging," and women-specific "worse performance IQ." frontiersin.org/articles/10.33…