PrudencioLab

Dr. Leonard Petrucelli has joined the Miller School of Medicine as Founding Director of the Neuroscience Institute. Dr. Petrucelli is a visionary scientist and a global leader in neurodegeneration research. His seminal work has uncovered the molecular mechanisms underpinning Alzheimer’s disease, frontotemporal dementia and ALS. His research reveals novel biomarkers and therapeutic targets that will help shape the next generation of treatments, helping to improve the lives of patients facing these devastating diseases. Welcome, Dr. Petrucelli! Read more: loom.ly/xQNlf4M

The MBI community gathered today to honor longtime colleague Dr. David Borchelt. Dr. Gopal Thinakaran, a close collaborator of Borchelt's, opened the First Annual David R. Borchelt Excellence in Neurodegeneration Research Seminar with a talk on BIN1’s role in Alzheimer’s.

Tracking #ALS early could transform care. Target ALS-backed scientists are developing blood & CSF tests for #CrypticPeptides—potential early biomarkers. Learn more: bit.ly/45vb0wc #ALSResearch #EveryoneLives

Dr. Leonard Petrucelli is a globally recognized leader in neurodegeneration and our longtime Scientific Advisor. He's been instrumental in shaping #ALSResearch and the very foundation of Target ALS. As he steps down from his role with us, we celebrate his partnership and vision.

NEW PAPER is out! We measured plasma p-tau217 and Aβ42/40 in 509 patients with the cognitive concerns. Worth a read if you're thinking of using blood-based biomarkers in the outpatient clinic. doi.org/10.1002/alz.70… @PiuraYoav1 @MayoClinic @MayoClinicNeuro @mayocliniclabs

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7 actaneurocomms.biomedcentral.com/articles/10.11…

Join us in celebrating our 2024 Cozzarelli Prize Class IV: Biomedical Sciences winning paper, “Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis.” Read more: ow.ly/SyAL50VyXLV

When #DanDoctoroff was diagnosed with #ALS, he saw an opportunity to make change. See what inspired him to found Target ALS to accelerate the discovery, development, and path to effective treatments. Take action today: targetals.org/take-action/ #ALSResearch #EveryoneLives

I was thrilled for the opportunity to present today at #ADPD2025 the work @PrudencioLab, in the wonderful city of Vienna where I was lucky to get an awesome tour by Dr Wilfried Rossoll!

Our manuscript got highlighted with a beautiful infographic! #TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS @PrudencioLab DOI: doi.org/10.1002/mds.30…

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes: nature.com/articles/s4146…

@alyssawalk1 I am so excited Dr Walker @alyssawalk1 has joined @PrudencioLab Looking forward to doing great work together!!

I joined the Prudencio lab at Mayo’s Department of Neuroscience as a Research Fellow last month! So exciting to be working on great science with this great group of ladies. #STEM #Neuroscience #TDP #TDP43 #proteostasis #proteinopathy #proteopathy

Very proud of this new study from the lab! 🌟We identified a novel lncRNA, FAM151B-DT, that is disrupted across neurodegenerative diseases. medrxiv.org/content/10.110…

A novel lncRNA FAM151B-DT regulates autophagy and degradation of aggregation prone proteins: medrxiv.org/content/10.110…

Excited to finally publish our work on cryptic splicing in Perry syndrome. Moreover, it higlights that not all cryptic RNAs are detected in every brain region with TDP-43 pathology. Enjoy! @PrudencioLab …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Great meeting! Thank you for letting me participate!