The Clevers Lab

Our countdown is never complete without a @TheCleversLab story! 😎 Their study of an in vitro model of mouse dorsal tongue epithelium holds 4th place in our countdown. 👏 If you missed the article in September, read it now. 👇 x.com/organoidscienc…

Using fluorescence real-time imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With @TheCleversLab. Great work by @NoordzijTomas & @CelottiMartina! @_Hubrecht biorxiv.org/content/10.648…

Daisong Wang and Sangho Lim describe human gut organoids with Peyer's patch M cells. M cells not only transport antigens: like professional antigen-presenting cells, they process and present gluten (the celiac disease antigen) directly to T cells rdcu.be/eT5s7

4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.

3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.

1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. science.org/doi/10.1126/sc…

Do you want to learn how to make mouse thymus organoids? Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue. Read it here: doi.org/10.1016/j.xpro… #Thymus #Organoids #STARProtocol #TEC

Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025. #ThymUS2025 #Organoids #Thymus

Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: the-scientist.com/a-novel-three-…

📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: sciencedirect.com/science/articl…

Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization. doi.org/10.1073/pnas.2…

Watch back the 2024 EMBL Kafatos Lecture where ⁦@HansClevers⁩ presented about the application of organoids in disease modeling at the ⁦@_knaw⁩ Amsterdam. #embl #knaw #organoids youtube.com/watch?v=eePX-M…

Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell division is triggered by IL-4, visualized in human gut AVIL-Clover reporter organoids (Credit: Daniel Krueger) nature.com/articles/s4158…

Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.

One bacterial protein as a complement to #Matrigel/#BME: The #integrin -binding domain of the Yersinia bacterial protein Invasin, coated as a single protein, maintains a defined long-term culture of various epithelial cells as “2D #organoid sheets”. biorxiv.org/content/10.110…

The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid

Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten star-protocols.cell.com/protocols/3589

Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! authors.elsevier.com/sd/article/S15….

British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet...)