TheFischerLab

Interested in adding a splash of water to your ligand discovery campaign? Check out our latest article: #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…

A GUI that seamlessly integrates FLEXR electron density based multi-conformer model building into Coot1's modeling and validation tools. journals.iucr.org/j/issues/2024/…

Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Exemplifies the power of collaboration at @StJudeResearch by CBT Chemistry Centers, @KlcoLab and @TheFischerLab funded by @AlexsLemonade. nature.com/articles/s4146…

The opus magnum of our PhD student Fatemeh, now @KymeraTx, is out in @BloodJournal in collaboration with the @CMullighan lab: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. ashpublications.org/blood/article-…

We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medicine! @StJudeResearch bit.ly/BC2M_2023

Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed a tool to help, which garnered new insights into the chaperone protein HSP90—an essential target in cancer. Read about their work. bit.ly/3LMhQVf

FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597…

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B doi.org/10.7554/eLife.…

Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks in protein cavities. pubs.acs.org/doi/10.1021/ac…

New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotspots on #HSP90, an important target in cancer. bit.ly/3SRxpwt @ACSBioMed

Thrilled to see @TheFischerLab's latest work on how "Water Networks Repopulate Protein-Ligand Interfaces With Temperature" out in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…

Excited to see our collaborative work on the “Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia” appear as a Plenary Paper in @BloodJournal with @CMullighan and #stjuderesearch CBT Chemistry Centers. authors.elsevier.com/a/1eDN%7E1UYwb…

What's under your mask? Happy #Movember2021! Support here: movember.com/m/mogul123?mc=1 Join here: movember.com/t/memstache?mc…

The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs/20699/pos…

Phenyl-Glutarimides improve PROTAC stability. Another great collaboration with the CBT ChemistryCenters @StJudeResearch and @TheFischerLab (and many others) just appeared in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…

Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :)

💥Enhanced sampling strikes again: we used aMD to see a buried apolar cavity open up to solvent, feeding this thermodynamic info to DOCK3.7 we saw some really cool new chemistry that also showed up in the beautiful crystals from Isha Singh 🎉🎉 #compchem #cadd @PNASNews

Expanding the chemical toolbox for bromodomain PHD finger transcription factor BPTF in a fun whirlwind collaboration with @fewill26 and @TheFischerLab. pubs.acs.org/doi/10.1021/ac…

Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article pubs.rsc.org/en/content/art…

🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front cover 😍 Read it here ➡️ Temperature artifacts in protein structures bias ligand-binding predictions 🔗 ow.ly/htjA50G2PSZ 📍 @UCIrvine | @StJudeResearch