Carlos Sequeiros-Borja

A great research opportunity is open now at my former lab. If you're interested in computational protein engineering, this call is for you. I learned a lot during my time under @JanBrezovsky1 group and can confirm that the mentoring is top tier 💯 linkedin.com/posts/jan-brez…

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@extrafabulous Those who know

Water will Find Its Way: Transport through Narrow Tunnels in Hydrolases #MolecularDynamics pubs.acs.org/doi/10.1021/ac… @carseq @surpeta_b @igorMarchlewski @JanBrezovsky1 @IIMCB_Poland @UAM_IBMiB #JCIM Vol64 Issue15 #compchem

@JanBrezovsky1 @_artgora @ACS4Authors @UAM_IBMiB And what a ride it was 😅

@_artgora @carseq @ACS4Authors @UAM_IBMiB Thanks, great end of one doctoral journey ;)

Super proud of @carseq work, both scientifically, but also sci-art. His cover idea was just published at JCIM! Cool art, interesting project, go see for yourselves :) pubs.acs.org/toc/jcisd8/64/… @ACS4Authors @UAM_IBMiB #sciart #compchem #biochem

@Nature What a shame seeing this type of "information" in one of the top scientific journals 😢

The daughter of a scientist and a supporter of diversity in STEM, Harris’s prospects have stirred optimism among scientists. go.nature.com/3y1Ta7q

@kmitusinska @JanBrezovsky1 @surpeta_b Thanks, it means a lot to me ☺️ This one in particular was quite the challenge, but I'm happy how it turned out

@carseq @JanBrezovsky1 @surpeta_b I'm a big fan of your graphics, @carseq <3 <3 <3

Finally, in pubs.acs.org/doi/10.1021/ac… we show that water molecules passing through wide tunnels make few or no H-bonds. However, in narrow tunnels, water molecules form several H-bonds to overcome repulsion and move efficiently @JanBrezovsky1 @surpeta_b #sciart #bioinformagician

In our recent paper pubs.acs.org/doi/10.1021/ac…, we observed that when water molecules cross shallow spaces, several Hydrogen bonds are formed with the protein to stabilize the transport @JanBrezovsky1 @surpeta_b @igorMarchlewski @aravind_ram_ Cedrix Dognmo More videos soon 😉

The insights we obtained, allowed us to provide a deeper explanation of phenotypical differences in a natural variant of the human epoxide hydrolase Kudos to my awesome team @JanBrezovsky1 @surpeta_b @igorMarchlewski @aravind_ram_ Cedrix Dongmo 3/3

We used three model system enzymes to uncover the limits for the transport of water molecules across their tunnel network 2/3

We know that water can traverse almost any barrier by entering minuscule spaces. Does the same happen at molecular level in proteins? In our recent paper, together with @JanBrezovsky1, we study and challenge common views of water transport in proteins pubs.acs.org/doi/10.1021/ac… 1/3

@MandalNishita @CG_Martini @NCN_PL @JanBrezovsky1 @UAM_IBMiB Congratulations Nishita 🥳

Super excited to share that our project to study coarse grained tunnels in collaboration with @CG_Martini has qualified for funding through very competitive #PRELUDIUM22 grant by the @NCN_PL 😍. Only 10.7% accepted this year! Special thanks to my PI @JanBrezovsky1 and @UAM_IBMiB

PhD Position (from Preludium BIS grant) in Plant Biology available in our group at @UAM_IBMiB Please RT Deadline: 30th August 2023 #PlantSciJobs #vacancies #jobs #PhDPoland #PhDposition

Burn it to the ground.

Here, we revisit the rules defining open tunnels in enzymes allowing them to work. So far, it was common to consider only those > 1.4 Å to be accessible to water molecules. Surprise, about 1/5 of waters flows by much smaller tunnels!! #Bioinformatics, #biotechnology #compchem

I’m very happy to see online our new review about my beloved SERRATE protein published in @TrendsPlantSci. Great collaboration with @MonikaJozwiak2 and Artur Jarmolowski and nice support from Zofia Szweykowska-Kulinska, and Dawid Bielewicz @plantrnagroup. dlvr.it/Sm0m30

On the other hand, non-substrate chemically similar compounds had to surmount considerably higher energy barriers to be transported 2/2

The results we got with @MedicagoCrew and @JanBrezovsky1 showed that natural substrates of our ABCG protein can traverse the tunnel without energetic penalties 🙂 Read all the spicy details at rdcu.be/c8FDF Last two animations for our paper #sciart #Blender3d 1/2