Guy Rutter1

Our appreciation in Diabetologia of Steve Ashcroft who sadly passed away in November. Steve made fundamental contributions to our understanding of beta cell glucose sensing including the substrate site hypothesis and the role of KATP channels.

@AidaMartinezS @SSunehera @ralen30 Delighted to be involved Aida! It’s a significant achievement to have described a pathway: glucose-AMPK-miR129b-MTFP1-mitochondrial ultrastructure and to show its relevance from living mice to human beta cells. #GiadaOstenilli @CRCHUM @CRCHUM_CELLS

Kudos to the hard work of the whole team, specially Sunehera Sarwat @SSunehera and Rosa Alen @ralen30, as well as amazing collaborators @guy_rutter, Tim Wai and Tristan Rodriguez

I am very happy to share the latest pre-print from our lab "MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis" biorxiv.org/content/10.648…

📢 #CIHR, #NSERC and #SSHRC are proud to launch the new Canada Impact+ Research Training Awards to support the recruitment of international doctoral students and postdoctoral researchers to Canada. Learn more about this new initiative: ▶️ tinyurl.com/yc54p4da

📢Today, the #GC launched new programs to attract international researchers to Canada. ✅ Canada Impact+ Research Chairs ✅ Canada Impact+ Emerging Leaders Get all the details here: canada.ca/en/impact-plus… @SSHRC_CRSH @NSERC_CRSNG @CIHR_IRSC @InnovationCA @ISED_CA

Leveraging the inhibition of disallowed beta cell genes as a therapeutic strategy!

Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.

29%—That's a lot of weight loss, folks Triple GLP-1 drug receptor retatrutide Compares with avg weight loss with Zepbound 21%, Wegovy (Ozempic) 15% nytimes.com/2025/12/11/hea…

ER calcium stores contribute to glucose-induced Ca2 waves and interce... sciencedirect.com/science/articl… Revisiting an old question with new tools! @L_F_D_S #BillLouch @CRCHUM @CRCHUM_CELLS @wellcometrust @CIHR_IRSC @BT1D_CA

Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia | Nature Metabolism nature.com/articles/s4225…

Out today in Diabetes! Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice | Diabetes | American Diabetes Association ⁦@CRCHUM⁩ ⁦@ImperialMDR⁩ diabetesjournals.org/diabetes/artic…

#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring pancreatic beta-cell subgroups and their connectivity nature.com/articles/s4225…

Relaunching our @CRCHUM Cardiometabolic Axis data sessions data sessions today with amazing talks from #mathiasguayasamin and #luisdelgadillosilva. #ciaranmurphyroyal @CRCHUM_CELLS

Not one, but TWO endocrinologists to join the Canadian Medical Hall of Fame in 2026. Both Drs Hegele and Zinman have changed the way we treat metabolic disorders forever. In addition though … they are just kind humans. Congratulations!!🎉🎊🎈

Important new review from my @CRCHUM colleague #MarcDonath

I‑BET151 modulates glucokinase gene expression and beta cellfunction in part through changes in FOXO1 expression rdcu.be/eIBCo Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition (I-BET151) impacts pancreatic β-cell function. 🔹 ↑ Glucose excursions 🔹 ↓ Insulin response 🔹 Downregulation of MODY genes (Hnf4α, Gck, Hnf1α, Glut2) & PI3K–Akt pathway ⚠️ BET therapies may impair β-cell health — caution warranted. #Diabetes #Epigenetics #BETinhibition

All true. But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.

Our new report with #YaChiHuang ⁦#MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv biorxiv.org/content/10.110…

#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring #pancreatic #BetaCell subgroups and their connectivity nature.com/articles/s4225…

Our new kid on the block to rival or beat existing dual agonists? Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001 - PubMed. pubmed.ncbi.nlm.nih.gov/40831316/

The influence of metformin treatment on the circulating proteome - PubMed. Important new study led by ⁦@LeentHart⁩ and the EU-funded IMI -Rhapsody and IMI-DIRECT consortia pubmed.ncbi.nlm.nih.gov/40684475/