Hellmann Lab

A lot is known about how #obesity influences the #AdiposeTissue. But what happens during weight loss and weight fluctuation is far less known. Check out our new review @atvbahajournals, led by @lourcatalina & @aleepta to learn more 👇👇 ahajournals.org/eprint/MI9IGEU…

We all know that weight loss in obesity is good- but why does it help? And why is weight regain afterward harmful? 🤔 Excited to announce our new paper is finally out in @JClinicalInvest! 🚀👇 jci.org/articles/view/…

@KevinH_PhD While terribly tragic and sad, my only hope is that this is simply the start of a new chapter in your scientific career that will lead to more accomplishments and insights.

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on unravelling the reasons why diets high in ultra-processed food are linked to epidemic proportions of chronic diseases such as diabetes and obesity. Our research leads the world on this topic. Given recent bipartisan goals to prevent diet-related chronic diseases, and new agency leadership professing to prioritize scientific investigation of ultra-processed foods, I had hoped to expand our research program with ambitious plans to more rapidly and efficiently determine how our food is likely making Americans chronically sick. Unfortunately, recent events have made me question whether NIH continues to be a place where I can freely conduct unbiased science. Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction. I was hoping this was an aberration. So, weeks ago I wrote to my agency’s leadership expressing my concerns and requested time to discuss these issues, but I never received a response. Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family. (Resigning later in protest of any future meddling or censorship would result in losing that benefit.) Due to very tight deadlines to make this decision, I don’t yet have plans for my future career. The NIH has been a wonderful place because it allows scientists to take risks, form unique collaborations, and do studies difficult to conduct elsewhere. I’m proud of what we’ve accomplished and I’m fortunate to have had such wonderful colleagues and scientific collaborators. I hope to someday return to government service and lead a research program that will continue to provide gold-standard science to make Americans healthy.

Omega-3 fatty acids reduce inflammation and improve endothelial dysfunction. A new meta-analysis linked higher omega-3 fatty acid levels in the blood to a 45% lower risk of cardiovascular death. Lets break it down🧵 1/9

truly a group effort with amazing colleagues led by Mallory Filipp PhD: Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction | Circulation ahajournals.org/doi/10.1161/CI…

@elonmusk As long as the apocalypse doesn’t involve any snow.

Cybertruck is apocalypse-level safe

@aryangovil @alexiskold @VPrasadMDMPH Source?

In some cases, a department head might have their PIs add them as a collaborator on an NIH RO1 for example, so they can get paid some tens of thousands of dollars per grant for doing nothing. Not sure how common of a practice is, but I immediately lose respect for department heads that do this.

Johns Hopkins president and dean are suing over indirects but their take home pay is like 4 million. Why should taxpayers give huge indirects to pay leadership these sums? I think all leadership need pay cuts.

Exercise is known to be good for us, but how much exercise and is there something like too much exercise? Exercise is often seen to have a J-shaped curve with mortality risk - not enough is bad but too much is also harmful (PMID: 26187713) How much is optimal then?⬇️⬇️

@elonmusk @elonmusk are you implying that these “siphoned funds” will be reallocated back to research awards?

Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”? What a ripoff!

Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏

@drjohnm What’s a better indicator of future MACE?

Reason number 36 to shun coronary calcium scans for screening.

Postdoctoral Position in Resolution of Inflammation. We are seeking for a recent PhD graduate to join our group at Yale! Please see the link for all details. postdocs.yale.edu/postdoctoral-p…

@AWeinstock Congratulations!

This Valentine's day the US and I decided to solidify our relationship forever 🇺🇲 🫡

Had an incredible time being back @BrighamWomens | @harvardmed learning about all the exciting new advancements in resolution pharmacology and SPM biology. A huge thanks to @CNSerhanLab , @SpiteLab , and all the other organizers for a wonderful symposium!

Having a fantastic time at the symposium on the Resolution of inflammation in medicine and surgery. @CNSerhanLab #startheresolution

@GabbyFredman @AlbanyMed @AlbanyMedMCP @MacNamaraLab @Forbes @WmHaseltine Great as always, @GabbyFredman!

Happy to share some press on our recent work! Couldn't have done this without my amazing team and colleagues! @AlbanyMed @AlbanyMedMCP @MacNamaraLab forbes.com/sites/williamh… Thank you @Forbes and @WmHaseltine.

@JuleenRZierath @JuleenRZierath the pleasure was all ours. Thank you again!

I had a fabulous visit to the Center for Cardiometabolic Science at the University of Louisville! I especially enjoyed meeting all the Phd and postdoc fellows, as well as the amazing center faculty! Many thanks for your hospitality! 💪👍

Excited to share our new @NatureComms study on eicosanoid inflammatory mediators and exercise intolerance in #HFpEF. Link: nature.com/articles/s4146… Co-led w Athar Roshandelpoor @MGHHeartHealth @mghcvrc @BidmcCvi 🙏 @JenHoCardiology