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i got my whole genome sequenced two years ago and forgot about it. last week i told my ai agent (@laukiantonson) to dig up my DNA files • it dug up a two-year-old email • found the download link • pulled down 67 gigabytes of raw DNA. • rented a 32-core, 64GB machine for a few hours — total cost: $5 • aligned 21 million long reads to the human reference genome — 99.83% mapped • called 5.8 million genetic variants using a two-pass neural network • phased every variant — separated maternal vs paternal inheritance • annotated all 5.8M variants against ClinVar, PharmGKB, and gnomAD • corrected for population-specific bias in the medical literature • health risk map across 39 conditions flagged in every body system • drug compatibility guide for 141 medications color-coded by genome response • nutrient metabolism - 71 variants affecting absorption of vitamins, minerals, iron • traits, ancestry going back 40,000 years, neanderthal DNA breakdown $5 in compute. 8 hours. no bioinformatician. no doctor. just one instruction. we've genuinely reached a point where an ai agent can take your raw genome and hand you back a full personal health profile in a single shot. i had no idea this was even possible.

@LefterisJP They needs all the tax they can find to pay for their debt

🇫🇷 I hope abductions, mutilations, deaths of relatives etc. will also be eligible for a good tax rebate under this totally sensible new scheme in a country that has had no problems with crypto users being attacked. /s

Before limited-releasing Claude Mythos Preview, we investigated its internal mechanisms with interpretability techniques. We found it exhibited notably sophisticated (and often unspoken) strategic thinking and situational awareness, at times in service of unwanted actions. (1/14)

Introducing Project Glasswing: an urgent initiative to help secure the world’s most critical software. It’s powered by our newest frontier model, Claude Mythos Preview, which can find software vulnerabilities better than all but the most skilled humans. anthropic.com/glasswing

Introducing GLM-5.1: The Next Level of Open Source - Top-Tier Performance: #1 in open source and #3 globally across SWE-Bench Pro, Terminal-Bench, and NL2Repo. - Built for Long-Horizon Tasks: Runs autonomously for 8 hours, refining strategies through thousands of iterations. Blog: z.ai/blog/glm-5.1 Weights: huggingface.co/zai-org/GLM-5.1 API: docs.z.ai/guides/llm/glm… Coding Plan: z.ai/subscribe Coming to chat.z.ai in the next few days.

AI Agent is perfect for validator devops works👍 I am thinking about wrapping all the common tasks into a skill or an agent.

NASA pilot Victor Glover CLAPS back after being asked what it means to be the first black man to visit the moon: “It’s the story of humanity, not black history, not women’s history, but that it becomes human history.” “I also HOPE we are pushing the other direction that one day we don’t have to talk about these first. That one day, this is just—and listen to this—that this is the human history.”

Google’s Gemma 4 E2B running on-device on iPhone 17 Pro Gemma 4 is built from the same research as Gemini 3, has image understanding capabilities and can reason if needed Running at ~40tk/s with MLX optimized for Apple Silicon

@fxnction models auth login --provider anthropic --method cli --set-default

The last year and half was the most interesting time of my life. All of sudden we are on track to become a civilization that I used to read in scifi books and dream of when I was a kid. All those deindustrialization movements have proven to be just a small ripple in the vast amount of human history. The human species want to advance itself no matter what. What an exciting time to be alive🚀

USDC is more decentralised than USDT🙈

Listened to this all-in podcast during my flight yesterday and I want to try out theoripical 5-MeO more than ever😁 // Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World...... youtu.be/Axpnkqd-Agk?is… via @YouTube

This is so cool🚀

This is a wild chart on Golf vs. Data Centers. Bottom line- people like golfers more than tech bros trying to centralize the world in AI dystopia 😂

@soniasinglas @EthCC @EthCCweek How should i sign up?

This shift is starting now. We’re discussing it with a small group of validators at @EthCC @EthCCweek If you are a validators & this resonates, we should chat 📥

This little illuminated dragon is very happy about Pretext. He's too busy having fun to care about people's "hot takes" on how "it's not that special." (This little dragon also only works on desktop right now but maybe I'll do mobile later) illustrated-manuscript.vercel.app

We’re teaming up with @ziskvm. As we scale rollups, proving latency and cost aren’t side concerns, they’re core constraints. Z ZisK delivers low-latency, distributed proving with 128-bit quantum-resistant security, so performance can scale without proving becoming the bottleneck. This only gets more critical with every rollup we launch.

AI on-call bot here we go🚀