Prof.Thomas Pulinilkunnil

Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes dlvr.it/TRzMsp

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade | Nature Communications nature.com/articles/s4146…

@itsmedipsikha Congratulations to you both and your respective families. Best wishes from all of us here!

4 years of togetherness culminated in an ever after... we got hitched! Blessed to have been surrounded by our respective families and friends during this mammoth endeavor of our big, fat Bengali wedding! #weddingmoments

1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s4158…

A paper I suggest reading if you are interested in Metabolism: "Here we show that extracellular lactate acts in a dose-dependent fashion to increase oxidative phosphorylation and suppress glycolysis". sciencedirect.com/science/articl…

CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46

New! Online now: NAMing the challenges and opportunities of new approach methodologies for studying cardiovascular metabolism dlvr.it/TQvJ28

Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. hubs.la/Q03ZR3-80

Nutrient Signalling and Metabolism Lab wishes you and family a wonderful Christmas and a healthy, joyful and productive New Year. Kudos to lab members on their accomplishments and contributions. Season’s Greetings from Pulinilkunnil @tpulinil and Kienesberger @PKienesberger labs.

It was a productive past week filled with outstanding scientific discussions and collaborative networking during my first-ever visit to Hamilton @MacMODR Thank you @DrGregSteinberg for the invitation and hospitality. I also enjoyed the 2025 @DiabetesCanada meeting in Toronto.

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations nature.com/articles/s4358…

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 | Science science.org/doi/10.1126/sc…

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases. (1/15) drive.google.com/file/d/1bSvkJW…

ONLINE NOW in @ScienceMagazine: CRI DeBerardini's Lab discovers protein regulating balance between purine nucleotide production pathways, read more ⬇️ cri.utsw.edu/deberardinis-l… #relentlentlessdiscovery @ScienceNews

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more in this week's issue: scim.ag/47FPKoj

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science science.org/doi/10.1126/sc…

@josephwgordon Yes we are back from the lockout, let us chat soon. How is your rest of the month looking like? We could connect next week!

@tpulinil Thanks Thomas, let catch up soon.

A comprehensive genetic catalog of human double-strand break repair | Science science.org/doi/10.1126/sc…

Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D nature.com/articles/s4158… @WashUDeptMed