Abe Bayer, PhD

@ASIPath @PilarAlcaidePhD What a crew!!!

ASIP 2025–2026 President, @PilarAlcaidePhD, will chair the Stowell Memorial President's Symposium at #Pathobiology2026! These speakers will share new findings in cardiac remodeling, and implications in cardiac dysfunction bit.ly/4cOCdPv #CardiacPathobiology

@SANDEEPBASU1 Congratulations!! That’s awesome

Excited and honored to share that I have been recognized as an Early Career Translational Investigator in JACC: Basic to Translational Science, where I am featured in a dedicated commentary highlighting early career investigators. I sincerely appreciate this recognition by Editor-in-Chief Matthias Nahrendorf. I am deeply thankful for the mentorship of @AartiAsnaniMD, the invaluable collaboration with Dr Ciara Metcalfe and the team at Genentech, as well as the dedicated contributions of all my co-authors. I look forward to continuing to contribute to translational cardiovascular research. jacc.org/doi/full/10.10… #EarlyCareerResearcher #TranslationalScience #CardiovascularResearch #CardioOncology #HarvardMedicalSchool #BIDMC

@SANDEEPBASU1 Congratulations!!! So exciting to see this out!

Some cancer therapies, while treating tumors, can also reveal unexpected effects on the heart! In this study, we uncover the mechanistic basis of sinus bradycardia observed in breast cancer patients treated with next-generation oral SERDs, using a powerful zebrafish preclinical model that faithfully recapitulates the clinical phenotype. We demonstrate that SERD-induced bradycardia is an on-target effect, mediated through nuclear Esr1 (ERα) signaling, rather than GPER-dependent or off-target pathways. Using Giredestrant, we show that this bradycardia is Esr1 dependent and can be effectively rescued by competitive estrogen receptor agonists. Together, these findings establish a direct mechanistic link between nuclear estrogen signaling and heart rate regulation. As SERDs move rapidly into clinical use for breast cancer therapy, understanding and mitigating cardiovascular side effects is critical. By establishing a preclinical system that mirrors patient responses, this work lays the foundation for developing strategies to preserve anticancer efficacy while reducing cardiovascular risk. I am deeply grateful to all my co-authors, my mentor @AartiAsnaniMD, and Dr. Ciara Metcalfe and her outstanding team at @genentech for their guidance, collaboration, and support throughout this work. Looking forward to continuing to contribute to translational cardiovascular science and drug discovery. #CardioOncology #HeartRate #EstrogenSignaling #PreclinicalModel #CRISPR #ZebrafishModel #JACCBTS #DrugDiscovery #CardiovascularResearch jacc.org/doi/10.1016/j.…

Targeting CIP4 (a scaffold for calcineurin) improved cardiac function after MI and in chronic ischemic cardiomyopathy in mice. Points to a new druggable pathway and proof-of-concept gene therapy for adverse cardiac remodeling. @AbeBayer @PilarAlcaidePhD ahajrnls.org/49arOvs

Excited to share this manuscript from Michael Kapiloffs lab fresh out in @JAHA_AHA, very happy @PilarAlcaidePhD and I were able to contribute! Congrats to the whole team @TuftsMedSchool @umiamimedicine @StanfordCVI ahajournals.org/doi/10.1161/JA…

@HanZhuMD @nwagner1026 @PilarAlcaidePhD @SWaliany @Ron_Witteles Thank you Han!!!! Was great to see you and your and Noah’s science presented

Goodbye, New Orleans #AHA2025 #AHA25. Congrats to @nwagner1026 from my lab for his poster on T cell/fibroblast crosstalk role in ici myocarditis. Also congrats to @AbeBayer from @PilarAlcaidePhD’s lab on winning Melvin Marcus. Wonderful to reunite with @SWaliany @Ron_Witteles 🤜🏻

@JonPHeart @PilarAlcaidePhD @BCVSearlyCareer Thank you all!!

@AbeBayer @PilarAlcaidePhD @BCVSearlyCareer Congratulations, Abe! Very deserving!

So deeply grateful for all of the mentorship I’ve received over the years. Thank you @PilarAlcaidePhD and @BCVSearlyCareer for this amazing honor

@Jenna_Mendelson @PilarAlcaidePhD @BCVSearlyCareer Thanks so much!!

@AbeBayer @PilarAlcaidePhD @BCVSearlyCareer Congrats Abe!

@FranCarrilloPhD @PilarAlcaidePhD @BCVSearlyCareer Thank you @FranCarrilloPhD ☺️

@AbeBayer @PilarAlcaidePhD @BCVSearlyCareer Congratulations Abe!

@AartiAsnaniMD @SumeetKhetarpal @PilarAlcaidePhD @HanZhuMD @AHAScience @BCVSearlyCareer Thank you so much!!! And congratulations @SumeetKhetarpal as well

A huge congratulations to @SumeetKhetarpal and @AbeBayer for winning the #AHA2025 Katz and Marcus awards in basic science! @PilarAlcaidePhD @HanZhuMD @AHAScience @BCVSearlyCareer

@nhpetunia @PilarAlcaidePhD @BCVSearlyCareer Thank you!!! You too

@AbeBayer @PilarAlcaidePhD @BCVSearlyCareer Congratulations! It was great seeing you!

@DrHelenECollin1 Thank you so so much

Well deserved

Thank you @AartiAsnaniMD !! Was excited for the opportunity to present some translational cardio oncology at @AHAScience @TuftsMCResearch

@Jess4genes Thank you so much!!!!

Congrats, Abe!! #AHA25

@PilarAlcaidePhD @umiamimedicine @SylvesterCancer Thank you so much! Could not be more grateful

Congratulations @AbeBayer for your stellar work in and talk and to all the outstanding finalists of the #Marcusaward #AHA25 competition. Special #proudmentor moment #cardioimmunology #cardiacfibrosis #cardioncology @umiamimedicine @SylvesterCancer

Beyond honored for the opportunity to present as a Marcus early career finalist. Thank you @AHAScience @BCVSearlyCareer @PilarAlcaidePhD for making this opportunity possible

For those at @AHAScience #AHA25 happening now in room 210, inflammatory mediators of inter organ crosstalk!

Checkout this fantastic #bcvs session at #AHA25 tomorrow morning! Looking forward to helping moderate @AHAScience @BCVSearlyCareer #cardioimmunology