Journal of Aging Science

Bone is a dynamic tissue that continually remodels and adapts throughout one's life. However, with aging, #age-related diseases, sedentary lifestyle, diet, and genetics all affect bone health. One of the most well-known aspects of #aging bone is a reduction in bone density.

•Cellular composition of the bone marrow (BM) compartment. •HSC self-renewal, differentiation and aging. •MSC lineage cells during aging. •HSC and MSC interaction in the bone marrow. •Molecular mechanism underlying skeletal aging. #Agingscience

#Psoriasis is a frequently misunderstood condition that is associated with significant stigma. Media portrayals of skin disorders can influence public beliefs about those disorders.

#Psoriasis is a chronic inflammatory dermatological condition that currently affects approximately 125 million people worldwide. It is characterized by epidermal cell hyperproliferation, aberrant differentiation of keratinocytes, and infiltration of dermis and epidermis.

#Biological ageing impairs the functional and structural properties of cells, leading to the gradual degradation of physiological systems, diminished resilience, heightened susceptibility to diseases, and, ultimately, mortality.

#Aging is an inevitable and intricate process that leads to the gradual decline of tissue and cellular functions, consequently increasing the risk of various age-related and geriatric diseases.

Testosterone (T) treatment immediately following traumatic brain injury (TBI) mitigates #cognitive deficits and cellular dysfunction known to induce cellular #senescence. Whether the therapeutic window for T treatment can be extended to a subacute time post-injury.

•Cellular #senescence progressively increases between one and two months after rmTBI. •Persistent #cognitive deficits are mitigated by delayed testosterone administration. •Delayed testosterone attenuates p16INK4a gene expression following rmTBI.

Electroencephalography (EEG), as an inexpensive and widely available electrophysiological tool, is commonly used for the diagnosis of #epilepsy and can also be used to assess the neural activity and brain network function of epilepsy patients with #cognitive impairment.

•Cognitive frailty represents a clinical connection between physical and cognitive decline. •Many biomarkers of physical frailty are also essential to understand #cognitive frailty. •Frailty modulates biomarker expression, gene and influences cognitive impairment prognosis.

#Aging is associated with a significant decline in steroid sex hormone levels, which impairs metabolic regulation and negatively affects overall health. The aging-induced reduction in steroid sex hormones may lead to muscle atrophy.

Steroid sex hormones, secreted by tissues including the reproductive organs, liver, kidney, brain, and skeletal muscles, play a crucial role in regulating various physiological functions such as energy metabolism and skeletal muscle hypertrophy. #Agingscience

#Cellular senescence, a characteristic feature of the aging process, is induced by diverse stressors. In recent years, glaucoma has emerged as a blinding ocular disease intricately linked to cellular senescence.

Ovarian #senescence refers to the physiological process by which ovarian function progressively declines with age, ultimately leading to ovarian failure. This process is primarily characterized by a decrease in both the quality and quantity of follicles.

#Telomeres are short, multi-repetitive, non-transcriptional sequences (TTAGGG) with associated binding proteins that act as a protector at the ends of chromosomes, preserving the integrity of genes.

•Neuropsychiatric disorders are syndromes of accelerated aging. •Telomere length, oxidation, and inflammation are #biomarkers of aging. •Opposing results on telomere length, oxidation, and #inflammation in those disorders.

•Proteostasis dysfunction in astrocytes may contribute to neurodegenerative diseases and #aging. •Different #proteostasis pathways in astrocytes may impact brain function and aging differently.

•miRNA profiles change in brain aging and related #Neurodegenerative Disorders (NDDs). •miRNAs regulating autophagy offer therapy for #age-related brain diseases. •Modulating miRNAs affecting #autophagy may help treat aging and NDDs.

#Psoriasis is a persistent autoimmune disease caused by genetic, immune, and infectious factors characterized by excessive epidermal proliferation and a chronic inflammatory reaction in the dermis. #Erythema and scaling are the main clinical manifestations.

#Psoriasis is a chronic recurrent inflammatory skin disease mediated by immune, genetic, and environmental factors. Numerous studies have demonstrated that the excessive consumption of certain pro-inflammatory foods, including alcohol and dairy products, can exacerbate psoriasis.