AlexGreenLab

Our paper on SNIPR riboregulators with SNP specificity is out today in @CellCellPress! SNIPRs can identify point mutations in bacteria and paper-based diagnostics for portable genotyping and drug-resistance testing.

Congratulations to Julien Berro @BerroLab @Yale and Alexander Green @AlexGreenLab @BioDesignCenter for “Intercepting the Cell’s Hidden Signals via Peptide-Activated RNA Switches.”

RCSA & @MooreFound announce awards of $1,320,000 to nine teams in the final year of #Scialog: Chemical Machinery of the Cell, an initiative launched in 2018 to advance fundamental understanding of chemical machinery and reactions in the intact cell. bit.ly/3s14uuZ

Engineers developing mail-in, no-touch, fast-scan test for COVID-19, other outbreaks News release: news.iastate.edu/news/2020/07/3… @ISU_CoE @IowaStateCBE #IowaStateInnovates

Thanks to @NSF for funding our collaborative, RAPID project to design a radically-new diagnostic that uses @AlexGreenLab toe-hold switch design, @PardeeLab cell free system, and our group's resonant sensors for widespread monitoring of #COVID 19 RNA. No reagents. No PPE. Awesome.

New #resource in the latest issue: high-specificity #RNA toehold-based #sensors allows for discrimination of point #mutations and RNA base #modifications and enables #genotypic #diagnosis for #Ecoli #human samples and #Zika #virus strains bit.ly/38uO54k

SNIPRs (Single-Nucleotide-Specific Programmable Riboregulators) take aim at disease-related mutations. biodesign.asu.edu/news/sniprs-ta… #ASUResearch @ASUChemistry

SNIPR design software developed by first author Fan Hong is on Github: github.com/Albert09111/SN… Plasmids will also be available on @Addgene soon.

Our paper on SNIPR riboregulators with SNP specificity is out today in @CellCellPress! SNIPRs can identify point mutations in bacteria and paper-based diagnostics for portable genotyping and drug-resistance testing.

Looking for some amazing training in Synthetic Biology? Check out the Cold Spring Harbor Synthetic Biology Summer Course! Applications due soon. cshlsynbio.wordpress.com

ASU, @UofT develop first direct gene-circuit-to-electrode interface. ow.ly/Juzy50xt6Wv #research @asunews

See also accompanying News & Views: nature.com/articles/s4155…

Check out our latest paper in @NatureChemistry led by @PardeeLab and @ShanaOKelley at the University of Toronto. Creating hybrid biomolecular/electronic systems by interfacing cell-free systems with electrochemical electrodes. nature.com/articles/s4155…

Terrific piece covering our work on RNA-based repressors for @asunews and @ASUBiodesign by Richard Harth. biodesign.asu.edu/news/%E2%80%99…

Wyss researchers have developed “Riborepressors” that, when integrated into synthetic gene circuits, enable reporter gene expression to be halted when the right signal is present. This could be applied in diagnostics, therapeutics, and biofabrication. wyss.harvard.edu/news/gene-off-…

Plasmids for the repressors are available for all to try through Addgene: addgene.org/browse/article…

Proud to have this paper published today in Nature Chemical Biology after a lot of work. We report two new RNA-based repressors that precisely turn off translation and can be used for RNA sensing, circuits, and diagnostics.

Congratulations to Mahmoud Matar Abed for successfully defending his Master's thesis and Suneet Kale for passing his comprehensive exam for the PhD program! Great work!

Our perspective discussing the present and future of research at the interface of synthetic biology and DNA/RNA nanotechnology just came out. Check it out here: portlandpress.com/emergtoplifesc…