BiochemPaul

Hesitate when you hear methemoglobinemia?? I promise, I ll make it a piece of cake for you. Here you go. Learn and live , students and residents. Easy peasy😇 #MedTwitter

🎊As we look forward to welcoming delegates to our annual conference this week, the ACBI celebrates an important milestone: 60 years since our foundation in 1964 🎊 @WeHSCPs @_EFLM @IFClinChem

🔥 Study evaluated a new approach to derive #reference #intervals using only 30 subjects and biological variation data. #LabMedX #PathTwitter 👇 buff.ly/48kDkCA

Direct-to-consumer testing as consumer initiated testing: compromises to the testing process and opportunities for quality improvement - Read on degruyter.com/document/doi/1… @degruyter_brill

Nicki minaj needs to step away from being obsessed with Megan, her concert in Dublin last night was a complete disaster, people are calling it the worst concert ever, 2 hours late, played for 40 minutes, and lip synced most of the songs.

Ann Bowron - there is no change in ammonia increase over time for samples on ice vs those at room temperature. Samples with an initial higher ammonia level showed LESS change over time. No benefit to transportation of ammonia samples on ice! #BIMDG24 @BowronAnn

Edmund has chest pain. The doctor orders troponin, a cardiac test for detecting heart attacks, and it’s positive. Diagnosis: heart attack. In reality, Edmund had a pulmonary embolism. Doctors will never discover this error. Follow the thread to understand the “troponin trap”.

Northern lights over @CoombeHospital last night ☺️

Today we celebrate National HSCP Day 2024. 0ur Clinical Biochemists and all HSCP colleagues work tirelessly in partnership to deliver high quality patient care #HSCPDay2024 #HSCPDeliver #Integratedcare @WeHSCPs @CcoHse @DonnellyStephen @BernardGloster @SteedFiona

When we published our study <evidence.nejm.org/doi/10.1056/EV…> of ODS and hyponatremia we were pummeled for including people at low risk of ODS because we included Na levels between 120 and 130. They said it is well known "that ODS is incredibly rare/non-existent at those levels." 1/4

Proud to have The Daisy Clinic in @CoombeHospital shared at @MidwiferyForum all Ireland midwifery festival today in the Helix by our ADOM Ann McEntyre!

Our review on the rising tide of Iatrogenic Adrenal insufficiency @julie22mg featured in NRE this month!

@bduric_ Doctors don’t wear them in Ireland. It’s outdated, unhygienic too. Should be bare below the elbow!

KDIGO is pleased to announce the publication of the 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD). Read the news release: kdigo.co/CKD-Guideline-… Download the guideline: kdigo.co/2024-CKD-Guide… Read the guideline in Kidney International: kdigo.co/CKD-Guideline-… The KDIGO 2024 CKD Guideline was co-chaired by @adeeralevin and @KidneysRU. The Executive Summary will be published in the April 2024 issue of @Kidney_Int. “We are thrilled to publish this eagerly anticipated update, which comes during a transformative period in nephrology, offering new hope for people living with kidney disease," said Dr. Levin. “Recent advancements in GFR evaluation, risk prediction, and the arrival of novel treatments are poised to enhance CKD prognosis and management. We also hope the guideline’s emphasis on multidisciplinary teamwork, patient engagement, and a holistic, evidence-based approach to care will help catalyze positive change, resulting in more coordinated CKD care management worldwide. By integrating the latest evidence and expert consensus, we aim to empower healthcare professionals, and patients with actionable recommendations to optimize patient outcomes and enhance quality of life.” “As Co-Chairs, we would like to recognize the outstanding efforts of the Guideline Work Group and extend our thanks to the Evidence Review Team from Johns Hopkins, without whom this guideline would not have been possible," said Dr. Stevens. "The Work Group was diverse, multinational, highly experienced, and exceptionally committed, and we are grateful for their contributions to both this guideline and to global nephrology.”

New Clinical Chemistry podcast: Eight Misconceptions about Prostate-Specific Antigen buff.ly/3tZ7tr8

1/8 SERUM FERRITIN Ferritin serves to store/sequester iron inside cells. Small amounts of ferritin are found in the serum and their levels are used clinically in the ddx of anemia and as an indicator of iron overload or inflammation.

CAUSES OF HYPERFERRITINEMIA (1) Inflammation (2) Iron overload (3) Ferritin leak (4) Congenital hyperferritinemia (5) Tumor secretion (malignancy-associated inflammation a more common cause) (6) Reduced clearance (theoretically) See PMID: 29672840

Dear Colleagues Please save the date for Irish Endocrine Society Annual Study Day 26th Jan 2024 at RCPI, Kildare Street, Dublin. We have an exciting programme with a line-up of distinguished speakers/experts in Diabetes & Endocrinology @FidelmaDunne @Physicianeer @RCPI_news

🔄 Monitoring hCG dynamics, coupled with transvaginal ultrasound, aids in the early detection and differentiation of ectopic pregnancies. ⚠️ Untreated ectopic pregnancies pose risks like tubal rupture, necessitating timely medical intervention, often through laparoscopic surgery.

📈 In a normal pregnancy, hCG levels rise exponentially, reaching a peak around the 10th week, and plateau thereafter. ⚖️ Ectopic pregnancies exhibit aberrant hCG patterns; levels may rise slower or plateau, deviating from the typical trajectory

🚼 Ectopic pregnancy: implantation of fertilized egg outside the uterine cavity, often in the fallopian tube. 🤰 Human chorionic gonadotropin (hCG): glycoprotein hormone produced by syncytiotrophoblast cells in the developing placenta.